Single cell type - OSBPL8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSBPL8
Gene descriptionⁱ Full gene name according to HGNC.	Oxysterol binding protein like 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes & Neutrophils - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OSBPL8 is part of cluster 19 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LYST	Lysosomal trafficking regulator	0.5078	19
PNPLA1	Patatin like phospholipase domain containing 1	0.4920	67
R3HDM2	R3H domain containing 2	0.4845	21
RNLS	Renalase, FAD dependent amine oxidase	0.4768	8
PAK1	P21 (RAC1) activated kinase 1	0.4757	21
DMXL2	Dmx like 2	0.4487	19
PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	0.4487	21
UHRF1BP1L	UHRF1 binding protein 1 like	0.4475	21
PLXNC1	Plexin C1	0.4420	19
GALNT14	Polypeptide N-acetylgalactosaminyltransferase 14	0.4351	8
NLRP12	NLR family pyrin domain containing 12	0.4340	19
BTK	Bruton tyrosine kinase	0.4335	57
CD33	CD33 molecule	0.4325	4
SGTB	Small glutamine rich tetratricopeptide repeat containing beta	0.4285	24
SIGLEC5	Sialic acid binding Ig like lectin 5	0.4261	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	63.5 nTPM
Adipose tissue	69.9 nTPM
Breast	57.1 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	58.3 nTPM
Lung	58.3 nTPM

Astrocytes	54.5 nTPM
Brain	54.5 nTPM

B-cells	87.8 nTPM
PBMC	135.7 nTPM
Colon	111.8 nTPM
Lymph node	105.2 nTPM
Adipose tissue	101.8 nTPM
Bone marrow	99.7 nTPM
Spleen	98.0 nTPM
Stomach	97.6 nTPM
Liver	43.8 nTPM
Kidney	42.9 nTPM
Breast	41.5 nTPM

Basal squamous epithelial cells	114.9 nTPM
Esophagus	114.9 nTPM

Dendritic cells	111.3 nTPM
PBMC	135.5 nTPM
Adipose tissue	112.8 nTPM
Breast	85.6 nTPM

Endothelial cells	68.7 nTPM
Pancreas	96.5 nTPM
Heart muscle	86.6 nTPM
Breast	76.1 nTPM
Lung	74.8 nTPM
Ovary	74.6 nTPM
Skin	71.8 nTPM
Testis	70.3 nTPM
Endometrium	67.3 nTPM
Skeletal muscle	63.0 nTPM
Liver	62.3 nTPM
Eye	61.5 nTPM
Prostate	60.8 nTPM
Esophagus	57.0 nTPM
Placenta	39.3 nTPM

Fibroblasts	98.0 nTPM
Prostate	262.2 nTPM
Adipose tissue	123.4 nTPM
Skin	116.5 nTPM
Esophagus	113.6 nTPM
Breast	96.7 nTPM
Skeletal muscle	87.4 nTPM
Heart muscle	86.1 nTPM
Stomach	55.0 nTPM
Lung	54.7 nTPM
Ovary	45.0 nTPM
Placenta	37.5 nTPM

Intestinal goblet cells	25.8 nTPM
Rectum	30.0 nTPM
Colon	25.0 nTPM
Small intestine	22.3 nTPM

Macrophages	142.0 nTPM
Prostate	211.0 nTPM
Spleen	180.4 nTPM
Stomach	178.7 nTPM
Adipose tissue	165.9 nTPM
Pancreas	155.7 nTPM
Bone marrow	150.0 nTPM
Endometrium	147.6 nTPM
Kidney	145.9 nTPM
Esophagus	144.8 nTPM
Skeletal muscle	137.0 nTPM
Testis	126.7 nTPM
Ovary	119.8 nTPM
Lung	108.0 nTPM
Breast	91.1 nTPM
PBMC	68.2 nTPM

Paneth cells	28.3 nTPM
Rectum	32.3 nTPM
Colon	26.4 nTPM
Small intestine	26.3 nTPM

Plasma cells	56.8 nTPM
Adipose tissue	119.9 nTPM
Spleen	50.4 nTPM
Stomach	49.2 nTPM
Esophagus	43.0 nTPM
Bone marrow	21.4 nTPM

Respiratory ciliated cells	37.4 nTPM
Lung	43.7 nTPM
Bronchus	31.1 nTPM

Smooth muscle cells	83.1 nTPM
Heart muscle	115.6 nTPM
Pancreas	110.2 nTPM
Prostate	100.1 nTPM
Ovary	94.3 nTPM
Adipose tissue	90.1 nTPM
Endometrium	88.6 nTPM
Esophagus	80.6 nTPM
Skeletal muscle	78.0 nTPM
Breast	66.4 nTPM
Skin	60.6 nTPM
Bronchus	30.1 nTPM

Collecting duct cells	51.5 nTPM
Kidney	51.5 nTPM

Cone photoreceptor cells	89.6 nTPM
Eye	89.6 nTPM

Cytotrophoblasts	34.8 nTPM
Placenta	34.8 nTPM

Distal enterocytes	13.6 nTPM
Rectum	16.9 nTPM
Colon	10.3 nTPM

T-cells	105.3 nTPM
Adipose tissue	234.0 nTPM
Skeletal muscle	166.4 nTPM
PBMC	134.8 nTPM
Colon	107.4 nTPM
Lung	106.3 nTPM
Stomach	104.3 nTPM
Prostate	104.2 nTPM
Esophagus	98.3 nTPM
Endometrium	92.4 nTPM
Lymph node	89.9 nTPM
Skin	87.0 nTPM
Breast	85.9 nTPM
Kidney	84.2 nTPM
Bone marrow	80.1 nTPM
Spleen	79.1 nTPM
Liver	69.7 nTPM
Ovary	66.8 nTPM

Undifferentiated cells	20.0 nTPM
Small intestine	32.2 nTPM
Rectum	15.3 nTPM
Colon	12.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC