Single cell type - OSGEP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSGEP
Gene descriptionⁱ Full gene name according to HGNC.	O-sialoglycoprotein endopeptidase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OSGEP is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SOWAHD	Sosondowah ankyrin repeat domain family member D	0.5177	38
STX7	Syntaxin 7	0.4645	57
POLM	DNA polymerase mu	0.4599	52
GTPBP3	GTP binding protein 3, mitochondrial	0.4569	32
TRMT1	TRNA methyltransferase 1	0.4524	57
LAPTM5	Lysosomal protein transmembrane 5	0.4402	57
NME6	NME/NM23 nucleoside diphosphate kinase 6	0.4398	7
PRR3	Proline rich 3	0.4384	57
AC007040.2	Novel protein	0.4353	47
HHEX	Hematopoietically expressed homeobox	0.4347	14
LY86	Lymphocyte antigen 86	0.4264	57
CDPF1	Cysteine rich DPF motif domain containing 1	0.4250	63
TCOF1	Treacle ribosome biogenesis factor 1	0.4227	41
CCDC51	Coiled-coil domain containing 51	0.4226	39
MRM2	Mitochondrial rRNA methyltransferase 2	0.4200	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.1 nTPM
Breast	35.8 nTPM
Adipose tissue	18.4 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	34.9 nTPM
Lung	34.9 nTPM

Astrocytes	16.3 nTPM
Brain	16.3 nTPM

Basal keratinocytes	11.5 nTPM
Skin	11.5 nTPM

B-cells	46.0 nTPM
Bone marrow	63.0 nTPM
Stomach	59.5 nTPM
Spleen	52.6 nTPM
Lymph node	51.5 nTPM
PBMC	48.5 nTPM
Kidney	47.6 nTPM
Breast	46.8 nTPM
Colon	38.3 nTPM
Adipose tissue	26.6 nTPM
Liver	25.7 nTPM

Dendritic cells	31.8 nTPM
Breast	40.5 nTPM
Adipose tissue	31.0 nTPM
PBMC	23.9 nTPM

Endothelial cells	24.1 nTPM
Placenta	50.1 nTPM
Eye	34.8 nTPM
Ovary	34.2 nTPM
Breast	29.1 nTPM
Liver	27.5 nTPM
Pancreas	23.1 nTPM
Skeletal muscle	20.0 nTPM
Testis	19.8 nTPM
Heart muscle	19.6 nTPM
Esophagus	18.8 nTPM
Skin	18.1 nTPM
Endometrium	18.0 nTPM
Lung	12.5 nTPM
Prostate	11.4 nTPM

Fibroblasts	23.4 nTPM
Ovary	39.9 nTPM
Breast	34.3 nTPM
Esophagus	28.4 nTPM
Placenta	25.2 nTPM
Stomach	23.7 nTPM
Skin	19.4 nTPM
Skeletal muscle	19.3 nTPM
Adipose tissue	19.1 nTPM
Prostate	17.9 nTPM
Lung	15.7 nTPM
Heart muscle	13.8 nTPM

Intestinal goblet cells	24.2 nTPM
Colon	26.4 nTPM
Rectum	23.3 nTPM
Small intestine	22.8 nTPM

Macrophages	34.2 nTPM
Breast	61.7 nTPM
PBMC	54.6 nTPM
Pancreas	46.0 nTPM
Ovary	40.8 nTPM
Kidney	37.1 nTPM
Prostate	34.4 nTPM
Esophagus	33.1 nTPM
Testis	32.0 nTPM
Endometrium	31.8 nTPM
Skeletal muscle	28.6 nTPM
Lung	28.3 nTPM
Adipose tissue	25.9 nTPM
Bone marrow	23.7 nTPM
Stomach	20.5 nTPM
Spleen	14.5 nTPM

Paneth cells	30.6 nTPM
Rectum	34.8 nTPM
Small intestine	33.8 nTPM
Colon	23.1 nTPM

Plasma cells	26.2 nTPM
Spleen	29.3 nTPM
Adipose tissue	27.1 nTPM
Stomach	26.8 nTPM
Esophagus	24.6 nTPM
Bone marrow	23.0 nTPM

Respiratory ciliated cells	25.5 nTPM
Lung	27.7 nTPM
Bronchus	23.3 nTPM

Smooth muscle cells	23.9 nTPM
Breast	33.0 nTPM
Esophagus	27.9 nTPM
Pancreas	26.7 nTPM
Prostate	26.5 nTPM
Skin	24.7 nTPM
Ovary	24.1 nTPM
Skeletal muscle	23.6 nTPM
Heart muscle	22.2 nTPM
Adipose tissue	19.7 nTPM
Endometrium	19.0 nTPM
Bronchus	15.1 nTPM

Cone photoreceptor cells	37.5 nTPM
Eye	37.5 nTPM

Cytotrophoblasts	66.3 nTPM
Placenta	66.3 nTPM

Distal tubular cells	35.2 nTPM
Kidney	35.2 nTPM

Early spermatids	3.1 nTPM
Testis	3.1 nTPM

T-cells	26.8 nTPM
Breast	36.9 nTPM
Lung	36.5 nTPM
Kidney	34.2 nTPM
PBMC	33.3 nTPM
Ovary	33.3 nTPM
Bone marrow	32.6 nTPM
Spleen	29.2 nTPM
Stomach	28.3 nTPM
Liver	27.5 nTPM
Lymph node	26.1 nTPM
Endometrium	25.3 nTPM
Colon	25.2 nTPM
Skin	24.9 nTPM
Skeletal muscle	24.7 nTPM
Adipose tissue	24.0 nTPM
Prostate	14.2 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	31.6 nTPM
Rectum	34.5 nTPM
Small intestine	33.5 nTPM
Colon	26.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC