Single cell type - TINF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TINF2
Gene descriptionⁱ Full gene name according to HGNC.	TERF1 interacting nuclear factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TINF2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RINL	Ras and Rab interactor like	0.6461	63
PATL2	PAT1 homolog 2	0.6218	63
ARHGAP25	Rho GTPase activating protein 25	0.6154	60
RAC2	Rac family small GTPase 2	0.6146	63
SASH3	SAM and SH3 domain containing 3	0.5861	63
IKZF3	IKAROS family zinc finger 3	0.5764	63
LIM2	Lens intrinsic membrane protein 2	0.5726	63
NCR3	Natural cytotoxicity triggering receptor 3	0.5711	63
UTS2	Urotensin 2	0.5704	63
CD160	CD160 molecule	0.5694	63
SLAMF6	SLAM family member 6	0.5685	63
TRDC	T cell receptor delta constant	0.5626	63
CHST12	Carbohydrate sulfotransferase 12	0.5594	63
TRGC1	T cell receptor gamma constant 1	0.5570	63
IL12RB1	Interleukin 12 receptor subunit beta 1	0.5523	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.6 nTPM
Breast	36.8 nTPM
Adipose tissue	32.5 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	23.0 nTPM
Lung	23.0 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	54.5 nTPM
Colon	100.6 nTPM
Stomach	74.9 nTPM
PBMC	71.3 nTPM
Kidney	52.4 nTPM
Spleen	50.8 nTPM
Bone marrow	48.3 nTPM
Adipose tissue	43.7 nTPM
Liver	41.8 nTPM
Lymph node	33.9 nTPM
Breast	26.8 nTPM

Dendritic cells	51.1 nTPM
Breast	53.2 nTPM
Adipose tissue	52.4 nTPM
PBMC	47.8 nTPM

Endothelial cells	31.4 nTPM
Prostate	47.7 nTPM
Pancreas	42.5 nTPM
Eye	41.2 nTPM
Testis	39.1 nTPM
Skeletal muscle	38.3 nTPM
Skin	32.8 nTPM
Ovary	30.9 nTPM
Heart muscle	27.1 nTPM
Esophagus	26.9 nTPM
Placenta	26.7 nTPM
Liver	26.6 nTPM
Breast	25.0 nTPM
Lung	18.7 nTPM
Endometrium	16.4 nTPM

Fibroblasts	28.1 nTPM
Lung	49.2 nTPM
Prostate	41.8 nTPM
Stomach	34.1 nTPM
Adipose tissue	29.4 nTPM
Skeletal muscle	26.4 nTPM
Esophagus	26.1 nTPM
Placenta	24.7 nTPM
Breast	24.4 nTPM
Skin	23.7 nTPM
Heart muscle	16.0 nTPM
Ovary	13.3 nTPM

Intestinal goblet cells	16.3 nTPM
Rectum	19.8 nTPM
Small intestine	15.4 nTPM
Colon	13.6 nTPM

Macrophages	29.9 nTPM
Stomach	41.0 nTPM
Ovary	40.9 nTPM
Kidney	37.8 nTPM
Spleen	35.3 nTPM
Bone marrow	33.8 nTPM
Prostate	33.2 nTPM
Adipose tissue	33.2 nTPM
Testis	32.6 nTPM
Lung	30.2 nTPM
Skeletal muscle	29.2 nTPM
Breast	28.1 nTPM
Pancreas	23.0 nTPM
Esophagus	20.4 nTPM
Endometrium	16.1 nTPM
PBMC	13.6 nTPM

Paneth cells	23.8 nTPM
Colon	26.4 nTPM
Rectum	26.4 nTPM
Small intestine	18.8 nTPM

Plasma cells	31.5 nTPM
Stomach	51.9 nTPM
Bone marrow	36.2 nTPM
Spleen	29.6 nTPM
Adipose tissue	27.7 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	9.5 nTPM
Bronchus	14.6 nTPM
Lung	4.4 nTPM

Smooth muscle cells	29.9 nTPM
Prostate	52.8 nTPM
Esophagus	38.8 nTPM
Heart muscle	36.1 nTPM
Pancreas	36.1 nTPM
Breast	33.5 nTPM
Skeletal muscle	30.8 nTPM
Skin	30.7 nTPM
Adipose tissue	25.9 nTPM
Ovary	21.4 nTPM
Endometrium	15.8 nTPM
Bronchus	6.6 nTPM

T-cells	46.5 nTPM
Ovary	71.2 nTPM
Kidney	65.1 nTPM
Colon	64.6 nTPM
Liver	62.3 nTPM
PBMC	55.6 nTPM
Stomach	52.2 nTPM
Bone marrow	51.3 nTPM
Esophagus	45.9 nTPM
Spleen	44.3 nTPM
Prostate	42.6 nTPM
Lung	41.0 nTPM
Adipose tissue	39.0 nTPM
Breast	38.1 nTPM
Skin	35.9 nTPM
Skeletal muscle	33.1 nTPM
Lymph node	24.6 nTPM
Endometrium	23.5 nTPM

Basal keratinocytes	16.8 nTPM
Skin	16.8 nTPM

Basal prostatic cells	63.8 nTPM
Prostate	63.8 nTPM

Basal respiratory cells	35.7 nTPM
Bronchus	35.7 nTPM

Cholangiocytes	15.7 nTPM
Liver	15.7 nTPM

Undifferentiated cells	15.6 nTPM
Rectum	16.7 nTPM
Small intestine	15.3 nTPM
Colon	14.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC