Single cell type - SNAP23 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNAP23
Gene descriptionⁱ Full gene name according to HGNC.	Synaptosome associated protein 23
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNAP23 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ITGA2B	Integrin subunit alpha 2b	0.6015	51
PTPN18	Protein tyrosine phosphatase non-receptor type 18	0.6002	51
YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	0.5926	51
FAM110A	Family with sequence similarity 110 member A	0.5759	51
MOB3C	MOB kinase activator 3C	0.5755	51
LGALS12	Galectin 12	0.5665	51
BPIFB3	BPI fold containing family B member 3	0.5658	51
ITGB3	Integrin subunit beta 3	0.5611	51
TREML1	Triggering receptor expressed on myeloid cells like 1	0.5596	51
CALM3	Calmodulin 3	0.5587	34
GPX1	Glutathione peroxidase 1	0.5587	51
RGS18	Regulator of G protein signaling 18	0.5579	51
RUFY1	RUN and FYVE domain containing 1	0.5499	51
GP9	Glycoprotein IX platelet	0.5492	51
CLEC1B	C-type lectin domain family 1 member B	0.5490	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	58.9 nTPM
Adipose tissue	66.7 nTPM
Breast	51.0 nTPM

Alveolar cells type 1	112.2 nTPM
Lung	112.2 nTPM

Alveolar cells type 2	30.5 nTPM
Lung	30.5 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

B-cells	79.0 nTPM
Kidney	123.8 nTPM
Bone marrow	102.2 nTPM
PBMC	100.0 nTPM
Lymph node	89.0 nTPM
Spleen	88.3 nTPM
Colon	76.7 nTPM
Stomach	68.1 nTPM
Adipose tissue	67.1 nTPM
Breast	42.8 nTPM
Liver	32.5 nTPM

Dendritic cells	45.3 nTPM
Adipose tissue	51.6 nTPM
PBMC	47.8 nTPM
Breast	36.4 nTPM

Endothelial cells	77.1 nTPM
Pancreas	119.6 nTPM
Esophagus	104.2 nTPM
Prostate	100.0 nTPM
Placenta	98.3 nTPM
Skin	92.8 nTPM
Testis	89.8 nTPM
Lung	71.7 nTPM
Skeletal muscle	66.5 nTPM
Breast	64.7 nTPM
Ovary	62.0 nTPM
Endometrium	61.8 nTPM
Liver	61.4 nTPM
Heart muscle	47.2 nTPM
Eye	39.7 nTPM

Fibroblasts	44.3 nTPM
Adipose tissue	59.5 nTPM
Prostate	58.3 nTPM
Placenta	57.6 nTPM
Skin	53.7 nTPM
Esophagus	46.1 nTPM
Stomach	46.0 nTPM
Skeletal muscle	36.8 nTPM
Heart muscle	36.0 nTPM
Ovary	32.5 nTPM
Breast	31.0 nTPM
Lung	30.1 nTPM

Intestinal goblet cells	80.2 nTPM
Colon	91.5 nTPM
Small intestine	81.1 nTPM
Rectum	68.1 nTPM

Macrophages	131.8 nTPM
PBMC	709.3 nTPM
Prostate	202.9 nTPM
Spleen	138.9 nTPM
Bone marrow	117.4 nTPM
Kidney	105.8 nTPM
Adipose tissue	88.4 nTPM
Esophagus	78.7 nTPM
Testis	78.4 nTPM
Endometrium	71.8 nTPM
Skeletal muscle	69.5 nTPM
Stomach	67.4 nTPM
Ovary	63.7 nTPM
Breast	62.2 nTPM
Pancreas	61.2 nTPM
Lung	60.8 nTPM

Paneth cells	52.8 nTPM
Rectum	53.1 nTPM
Colon	52.6 nTPM
Small intestine	52.6 nTPM

Plasma cells	27.9 nTPM
Stomach	36.2 nTPM
Adipose tissue	33.6 nTPM
Spleen	31.2 nTPM
Bone marrow	26.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	42.6 nTPM
Lung	45.2 nTPM
Bronchus	40.1 nTPM

Smooth muscle cells	40.6 nTPM
Pancreas	77.2 nTPM
Skin	51.6 nTPM
Prostate	51.3 nTPM
Esophagus	44.9 nTPM
Heart muscle	41.9 nTPM
Ovary	38.7 nTPM
Adipose tissue	34.6 nTPM
Skeletal muscle	32.5 nTPM
Endometrium	27.3 nTPM
Bronchus	23.6 nTPM
Breast	23.4 nTPM

T-cells	48.2 nTPM
Prostate	104.2 nTPM
Lung	68.4 nTPM
Kidney	60.9 nTPM
PBMC	53.1 nTPM
Colon	51.8 nTPM
Lymph node	48.8 nTPM
Bone marrow	48.4 nTPM
Spleen	48.2 nTPM
Adipose tissue	44.8 nTPM
Ovary	44.5 nTPM
Skeletal muscle	44.3 nTPM
Liver	42.6 nTPM
Stomach	41.3 nTPM
Skin	40.9 nTPM
Endometrium	32.6 nTPM
Breast	30.8 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	50.7 nTPM
Skin	50.7 nTPM

Basal prostatic cells	107.6 nTPM
Prostate	107.6 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Cholangiocytes	38.6 nTPM
Liver	38.6 nTPM

Undifferentiated cells	39.7 nTPM
Colon	44.9 nTPM
Rectum	37.5 nTPM
Small intestine	36.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC