Single cell type - ACOT7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACOT7
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA thioesterase 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Late spermatids, granulocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (NK-cell, plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Late spermatids, granulocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACOT7 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC5A12	Solute carrier family 5 member 12	0.6759	67
SLC34A3	Solute carrier family 34 member 3	0.6472	67
CUBN	Cubilin	0.6428	67
SMIM24	Small integral membrane protein 24	0.6410	67
SLC28A1	Solute carrier family 28 member 1	0.6171	67
PKLR	Pyruvate kinase L/R	0.6162	67
FAM151A	Family with sequence similarity 151 member A	0.6158	67
PBLD	Phenazine biosynthesis like protein domain containing	0.6122	67
KHK	Ketohexokinase	0.6105	67
GIPC2	GIPC PDZ domain containing family member 2	0.6080	67
FAHD1	Fumarylacetoacetate hydrolase domain containing 1	0.6076	67
TMEM252	Transmembrane protein 252	0.6042	67
CHDH	Choline dehydrogenase	0.6018	67
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.5972	67
LGALS2	Galectin 2	0.5958	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.4 nTPM
Adipose tissue	4.0 nTPM
Breast	2.9 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	16.4 nTPM
Lung	16.4 nTPM

Astrocytes	9.4 nTPM
Brain	9.4 nTPM

B-cells	4.9 nTPM
Liver	23.7 nTPM
Kidney	14.3 nTPM
Colon	3.2 nTPM
Spleen	2.4 nTPM
Lymph node	1.7 nTPM
Stomach	1.4 nTPM
Breast	1.3 nTPM
Adipose tissue	1.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	14.4 nTPM
PBMC	16.0 nTPM
Adipose tissue	14.0 nTPM
Breast	13.1 nTPM

Endothelial cells	19.1 nTPM
Placenta	48.9 nTPM
Pancreas	42.5 nTPM
Ovary	41.7 nTPM
Endometrium	22.7 nTPM
Lung	21.8 nTPM
Prostate	18.1 nTPM
Skin	13.8 nTPM
Liver	13.7 nTPM
Eye	10.5 nTPM
Heart muscle	9.4 nTPM
Skeletal muscle	8.0 nTPM
Esophagus	6.7 nTPM
Testis	6.2 nTPM
Breast	3.6 nTPM

Fibroblasts	11.5 nTPM
Ovary	32.5 nTPM
Placenta	28.0 nTPM
Skin	17.8 nTPM
Stomach	10.4 nTPM
Lung	7.8 nTPM
Skeletal muscle	5.8 nTPM
Adipose tissue	5.7 nTPM
Prostate	5.3 nTPM
Esophagus	5.2 nTPM
Breast	4.8 nTPM
Heart muscle	2.8 nTPM

Intestinal goblet cells	110.2 nTPM
Small intestine	139.3 nTPM
Colon	131.5 nTPM
Rectum	59.8 nTPM

Macrophages	13.4 nTPM
Lung	73.3 nTPM
Kidney	21.1 nTPM
Endometrium	19.1 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Adipose tissue	11.5 nTPM
Esophagus	9.4 nTPM
Prostate	9.1 nTPM
Skeletal muscle	9.0 nTPM
Breast	6.5 nTPM
Spleen	5.2 nTPM
Ovary	5.0 nTPM
Testis	4.0 nTPM
Bone marrow	1.2 nTPM
Stomach	0.0 nTPM

Paneth cells	41.8 nTPM
Small intestine	63.8 nTPM
Rectum	32.1 nTPM
Colon	29.6 nTPM

Plasma cells	9.3 nTPM
Spleen	19.8 nTPM
Bone marrow	9.9 nTPM
Adipose tissue	7.0 nTPM
Esophagus	6.1 nTPM
Stomach	3.9 nTPM

Respiratory ciliated cells	7.1 nTPM
Bronchus	12.8 nTPM
Lung	1.5 nTPM

Smooth muscle cells	17.6 nTPM
Pancreas	77.1 nTPM
Bronchus	40.7 nTPM
Ovary	18.1 nTPM
Endometrium	14.5 nTPM
Skin	10.8 nTPM
Prostate	6.5 nTPM
Esophagus	6.2 nTPM
Skeletal muscle	5.3 nTPM
Heart muscle	5.0 nTPM
Adipose tissue	5.0 nTPM
Breast	4.2 nTPM

T-cells	21.7 nTPM
Prostate	61.6 nTPM
Skin	50.2 nTPM
Kidney	38.3 nTPM
Esophagus	32.8 nTPM
Stomach	32.2 nTPM
Colon	23.3 nTPM
Lung	19.7 nTPM
Skeletal muscle	19.1 nTPM
Liver	15.9 nTPM
Ovary	13.4 nTPM
Spleen	12.9 nTPM
Bone marrow	11.9 nTPM
Adipose tissue	11.1 nTPM
Endometrium	9.3 nTPM
Breast	6.2 nTPM
Lymph node	5.6 nTPM
PBMC	5.0 nTPM

Basal keratinocytes	31.7 nTPM
Skin	31.7 nTPM

Basal prostatic cells	16.5 nTPM
Prostate	16.5 nTPM

Basal respiratory cells	24.2 nTPM
Bronchus	24.2 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Undifferentiated cells	51.3 nTPM
Small intestine	64.4 nTPM
Colon	63.3 nTPM
Rectum	26.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC