Single cell type - KCNK6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KCNK6
Gene descriptionⁱ Full gene name according to HGNC.	Potassium two pore domain channel subfamily K member 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters Voltage-gated ion channels
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatic stellate cells, Urothelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, HMC-1, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatic stellate cells, Urothelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KCNK6 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SMR3A	Submaxillary gland androgen regulated protein 3A	0.5688	30
TEX45	Testis expressed 45	0.5306	44
CREB3L1	CAMP responsive element binding protein 3 like 1	0.5261	27
SPAG11B	Sperm associated antigen 11B	0.5218	44
SEC24A	SEC24 homolog A, COPII coat complex component	0.4901	44
DENND2C	DENN domain containing 2C	0.4866	44
RAP2B	RAP2B, member of RAS oncogene family	0.4853	44
CNMD	Chondromodulin	0.4836	7
ZNF217	Zinc finger protein 217	0.4813	44
CKAP4	Cytoskeleton associated protein 4	0.4802	55
CAVIN4	Caveolae associated protein 4	0.4674	44
ESR1	Estrogen receptor 1	0.4642	44
AC068533.4	Novel protein	0.4624	7
C1orf74	Chromosome 1 open reading frame 74	0.4603	44
SERINC5	Serine incorporator 5	0.4600	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.7 nTPM
Adipose tissue	9.2 nTPM
Breast	8.1 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	10.5 nTPM
Lung	10.5 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	16.0 nTPM
Liver	58.1 nTPM
Breast	28.1 nTPM
PBMC	20.0 nTPM
Adipose tissue	15.0 nTPM
Kidney	14.3 nTPM
Colon	8.0 nTPM
Spleen	6.9 nTPM
Stomach	5.9 nTPM
Lymph node	3.2 nTPM
Bone marrow	0.8 nTPM

Dendritic cells	18.5 nTPM
PBMC	31.8 nTPM
Breast	12.0 nTPM
Adipose tissue	11.5 nTPM

Endothelial cells	28.3 nTPM
Liver	219.2 nTPM
Pancreas	27.0 nTPM
Heart muscle	23.0 nTPM
Testis	22.8 nTPM
Placenta	18.8 nTPM
Lung	18.7 nTPM
Skeletal muscle	13.1 nTPM
Prostate	12.0 nTPM
Endometrium	11.1 nTPM
Breast	11.1 nTPM
Ovary	9.6 nTPM
Eye	4.8 nTPM
Skin	2.8 nTPM
Esophagus	2.6 nTPM

Fibroblasts	19.2 nTPM
Lung	90.4 nTPM
Placenta	59.3 nTPM
Ovary	17.6 nTPM
Heart muscle	12.6 nTPM
Skeletal muscle	5.9 nTPM
Skin	5.1 nTPM
Breast	5.1 nTPM
Prostate	4.6 nTPM
Stomach	4.4 nTPM
Adipose tissue	3.3 nTPM
Esophagus	2.5 nTPM

Intestinal goblet cells	64.5 nTPM
Colon	74.3 nTPM
Small intestine	68.3 nTPM
Rectum	50.9 nTPM

Macrophages	47.0 nTPM
PBMC	109.1 nTPM
Testis	66.9 nTPM
Pancreas	58.7 nTPM
Kidney	55.2 nTPM
Endometrium	53.3 nTPM
Adipose tissue	48.8 nTPM
Lung	44.8 nTPM
Esophagus	44.1 nTPM
Bone marrow	42.5 nTPM
Breast	42.3 nTPM
Skeletal muscle	41.6 nTPM
Ovary	39.2 nTPM
Prostate	26.3 nTPM
Spleen	20.7 nTPM
Stomach	11.7 nTPM

Paneth cells	39.2 nTPM
Colon	59.3 nTPM
Rectum	43.4 nTPM
Small intestine	15.0 nTPM

Plasma cells	45.6 nTPM
Stomach	62.3 nTPM
Spleen	57.1 nTPM
Bone marrow	54.4 nTPM
Adipose tissue	41.9 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	7.7 nTPM
Bronchus	8.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	9.3 nTPM
Endometrium	46.2 nTPM
Ovary	14.5 nTPM
Pancreas	11.6 nTPM
Heart muscle	10.2 nTPM
Prostate	7.8 nTPM
Bronchus	4.8 nTPM
Skeletal muscle	3.4 nTPM
Skin	2.5 nTPM
Breast	1.6 nTPM
Adipose tissue	0.2 nTPM
Esophagus	0.0 nTPM

T-cells	14.8 nTPM
Prostate	42.6 nTPM
Ovary	22.3 nTPM
Adipose tissue	21.6 nTPM
PBMC	20.6 nTPM
Skeletal muscle	19.1 nTPM
Endometrium	18.7 nTPM
Breast	18.4 nTPM
Skin	15.2 nTPM
Liver	14.5 nTPM
Colon	10.9 nTPM
Kidney	10.9 nTPM
Lung	10.6 nTPM
Spleen	7.1 nTPM
Lymph node	6.8 nTPM
Stomach	6.1 nTPM
Bone marrow	6.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	43.1 nTPM
Skin	43.1 nTPM

Basal prostatic cells	50.6 nTPM
Prostate	50.6 nTPM

Basal squamous epithelial cells	20.5 nTPM
Esophagus	20.5 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	26.7 nTPM
Rectum	31.1 nTPM
Small intestine	28.7 nTPM
Colon	20.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC