Single cell type - SBF1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SBF1
Gene descriptionⁱ Full gene name according to HGNC.	SET binding factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SBF1 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCAR2	Cell cycle and apoptosis regulator 2	0.5349	58
ZNF646	Zinc finger protein 646	0.5345	66
PRRC2A	Proline rich coiled-coil 2A	0.5278	59
FCHSD1	FCH and double SH3 domains 1	0.5047	58
LLGL1	LLGL scribble cell polarity complex component 1	0.4947	58
PPP6R1	Protein phosphatase 6 regulatory subunit 1	0.4913	29
KCTD13	Potassium channel tetramerization domain containing 13	0.4781	20
PHRF1	PHD and ring finger domains 1	0.4672	10
DCAF15	DDB1 and CUL4 associated factor 15	0.4584	7
ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	0.4543	42
SUN2	Sad1 and UNC84 domain containing 2	0.4494	63
ZNF668	Zinc finger protein 668	0.4424	29
ZC3H3	Zinc finger CCCH-type containing 3	0.4288	40
SF3B3	Splicing factor 3b subunit 3	0.4242	59
SCML4	Scm polycomb group protein like 4	0.4241	58

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.7 nTPM
Breast	6.5 nTPM
Adipose tissue	4.8 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	11.8 nTPM
Lung	11.8 nTPM

Astrocytes	10.7 nTPM
Brain	10.7 nTPM

B-cells	13.7 nTPM
Lymph node	26.6 nTPM
Stomach	20.9 nTPM
Colon	16.0 nTPM
Kidney	14.3 nTPM
Breast	13.4 nTPM
Adipose tissue	11.1 nTPM
Spleen	11.1 nTPM
Bone marrow	10.6 nTPM
Liver	9.2 nTPM
PBMC	4.3 nTPM

Dendritic cells	21.4 nTPM
Adipose tissue	23.7 nTPM
Breast	20.4 nTPM
PBMC	20.0 nTPM

Endothelial cells	5.6 nTPM
Ovary	10.5 nTPM
Pancreas	7.7 nTPM
Liver	7.3 nTPM
Skeletal muscle	7.0 nTPM
Breast	6.8 nTPM
Heart muscle	6.3 nTPM
Esophagus	6.2 nTPM
Prostate	5.9 nTPM
Endometrium	5.6 nTPM
Skin	4.3 nTPM
Testis	4.1 nTPM
Placenta	3.4 nTPM
Eye	3.3 nTPM
Lung	0.0 nTPM

Fibroblasts	10.6 nTPM
Ovary	18.8 nTPM
Skeletal muscle	13.5 nTPM
Lung	13.4 nTPM
Placenta	11.0 nTPM
Adipose tissue	10.3 nTPM
Prostate	8.9 nTPM
Esophagus	8.9 nTPM
Stomach	8.9 nTPM
Breast	8.9 nTPM
Skin	8.6 nTPM
Heart muscle	5.1 nTPM

Intestinal goblet cells	13.2 nTPM
Small intestine	15.0 nTPM
Colon	14.3 nTPM
Rectum	10.2 nTPM

Macrophages	9.5 nTPM
Esophagus	15.8 nTPM
Skeletal muscle	15.0 nTPM
Breast	12.9 nTPM
Bone marrow	12.5 nTPM
Adipose tissue	12.2 nTPM
Stomach	11.7 nTPM
Endometrium	11.6 nTPM
Spleen	11.4 nTPM
Ovary	8.5 nTPM
Pancreas	7.7 nTPM
Kidney	7.6 nTPM
Lung	7.3 nTPM
Prostate	4.6 nTPM
Testis	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	8.1 nTPM
Colon	13.2 nTPM
Rectum	11.1 nTPM
Small intestine	0.0 nTPM

Plasma cells	15.6 nTPM
Adipose tissue	23.9 nTPM
Bone marrow	19.8 nTPM
Spleen	15.2 nTPM
Stomach	13.0 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	11.1 nTPM
Bronchus	15.0 nTPM
Lung	7.3 nTPM

Smooth muscle cells	11.6 nTPM
Bronchus	23.6 nTPM
Ovary	15.7 nTPM
Esophagus	14.0 nTPM
Skeletal muscle	13.2 nTPM
Adipose tissue	11.2 nTPM
Breast	10.3 nTPM
Pancreas	9.8 nTPM
Endometrium	9.8 nTPM
Skin	8.7 nTPM
Prostate	7.5 nTPM
Heart muscle	3.9 nTPM

T-cells	19.8 nTPM
Esophagus	32.8 nTPM
Lymph node	30.5 nTPM
Breast	29.5 nTPM
Ovary	26.7 nTPM
Stomach	25.9 nTPM
Spleen	25.7 nTPM
Skeletal muscle	23.9 nTPM
Bone marrow	21.6 nTPM
Lung	19.7 nTPM
Adipose tissue	19.4 nTPM
Endometrium	17.3 nTPM
Liver	16.3 nTPM
Colon	14.7 nTPM
PBMC	14.5 nTPM
Skin	11.1 nTPM
Kidney	7.5 nTPM
Prostate	0.0 nTPM

Basal respiratory cells	9.3 nTPM
Bronchus	9.3 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Cytotrophoblasts	4.9 nTPM
Placenta	4.9 nTPM

Undifferentiated cells	12.3 nTPM
Rectum	14.7 nTPM
Colon	13.7 nTPM
Small intestine	8.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC