Single cell type - PRRC2A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRRC2A
Gene descriptionⁱ Full gene name according to HGNC.	Proline rich coiled-coil 2A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT, HEK93, U-266/70, U-266/84, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRRC2A is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.89
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.6807	59
BRPF1	Bromodomain and PHD finger containing 1	0.6619	10
MTA2	Metastasis associated 1 family member 2	0.6485	59
USP21	Ubiquitin specific peptidase 21	0.5912	59
CACTIN	Cactin, spliceosome C complex subunit	0.5612	7
KHDRBS1	KH RNA binding domain containing, signal transduction associated 1	0.5610	59
HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B	0.5575	10
RAVER1	Ribonucleoprotein, PTB binding 1	0.5560	59
SKIV2L	Ski2 like RNA helicase	0.5437	59
CCAR2	Cell cycle and apoptosis regulator 2	0.5420	58
ATP13A1	ATPase 13A1	0.5411	53
SBF1	SET binding factor 1	0.5278	59
MYBBP1A	MYB binding protein 1a	0.5180	39
PHRF1	PHD and ring finger domains 1	0.5169	10
NOP2	NOP2 nucleolar protein	0.5126	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.3 nTPM
Adipose tissue	42.8 nTPM
Breast	35.6 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	5.5 nTPM
Lung	5.5 nTPM

Astrocytes	25.5 nTPM
Brain	25.5 nTPM

B-cells	39.2 nTPM
Lymph node	67.9 nTPM
Spleen	55.0 nTPM
Stomach	51.3 nTPM
Bone marrow	45.8 nTPM
Colon	41.5 nTPM
Breast	36.0 nTPM
PBMC	32.9 nTPM
Liver	28.9 nTPM
Adipose tissue	23.1 nTPM
Kidney	9.5 nTPM

Dendritic cells	38.0 nTPM
Adipose tissue	39.5 nTPM
Breast	38.6 nTPM
PBMC	35.8 nTPM

Endothelial cells	33.4 nTPM
Ovary	57.0 nTPM
Prostate	50.5 nTPM
Esophagus	48.0 nTPM
Endometrium	47.9 nTPM
Skeletal muscle	47.9 nTPM
Testis	36.1 nTPM
Eye	34.0 nTPM
Placenta	33.5 nTPM
Skin	30.8 nTPM
Breast	29.9 nTPM
Liver	23.8 nTPM
Pancreas	23.1 nTPM
Heart muscle	5.3 nTPM
Lung	0.0 nTPM

Fibroblasts	32.9 nTPM
Ovary	65.3 nTPM
Stomach	40.1 nTPM
Skeletal muscle	38.6 nTPM
Esophagus	38.6 nTPM
Placenta	34.7 nTPM
Skin	33.3 nTPM
Adipose tissue	33.3 nTPM
Prostate	32.5 nTPM
Breast	30.2 nTPM
Lung	12.3 nTPM
Heart muscle	3.1 nTPM

Intestinal goblet cells	39.1 nTPM
Rectum	46.1 nTPM
Small intestine	38.9 nTPM
Colon	32.2 nTPM

Macrophages	31.4 nTPM
Bone marrow	53.7 nTPM
Esophagus	51.9 nTPM
Spleen	50.8 nTPM
Ovary	39.6 nTPM
Adipose tissue	39.1 nTPM
Breast	35.2 nTPM
Skeletal muscle	33.4 nTPM
Endometrium	30.4 nTPM
Pancreas	28.0 nTPM
Kidney	27.2 nTPM
Testis	24.4 nTPM
Prostate	21.8 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM
Lung	6.4 nTPM

Paneth cells	37.8 nTPM
Small intestine	45.0 nTPM
Rectum	41.9 nTPM
Colon	26.4 nTPM

Plasma cells	47.2 nTPM
Adipose tissue	64.6 nTPM
Bone marrow	51.1 nTPM
Spleen	50.4 nTPM
Stomach	39.2 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	20.1 nTPM
Bronchus	35.8 nTPM
Lung	4.4 nTPM

Smooth muscle cells	44.8 nTPM
Bronchus	99.2 nTPM
Skeletal muscle	59.9 nTPM
Ovary	53.3 nTPM
Esophagus	48.0 nTPM
Skin	44.7 nTPM
Adipose tissue	41.9 nTPM
Endometrium	41.3 nTPM
Breast	40.5 nTPM
Prostate	34.0 nTPM
Pancreas	23.7 nTPM
Heart muscle	6.0 nTPM

T-cells	38.2 nTPM
Lymph node	65.1 nTPM
Spleen	61.3 nTPM
Bone marrow	59.3 nTPM
Stomach	53.6 nTPM
Skeletal muscle	46.8 nTPM
Esophagus	45.9 nTPM
Endometrium	40.1 nTPM
Skin	39.6 nTPM
Breast	38.8 nTPM
Liver	37.3 nTPM
Adipose tissue	36.7 nTPM
Ovary	33.3 nTPM
PBMC	30.7 nTPM
Colon	28.5 nTPM
Kidney	21.2 nTPM
Prostate	9.5 nTPM
Lung	1.5 nTPM

Basal prostatic cells	28.4 nTPM
Prostate	28.4 nTPM

Basal respiratory cells	26.1 nTPM
Bronchus	26.1 nTPM

Basal squamous epithelial cells	67.7 nTPM
Esophagus	67.7 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Undifferentiated cells	48.0 nTPM
Colon	51.9 nTPM
Rectum	49.6 nTPM
Small intestine	42.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC