Single cell type - CHKB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHKB
Gene descriptionⁱ Full gene name according to HGNC.	Choline kinase beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes - Immune response regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CHKB is part of cluster 3 Monocytes - Immune response regulation with confidenceⁱ 1
114 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SNX15	Sorting nexin 15	0.6251	53
OR2I1P	Olfactory receptor family 2 subfamily I member 1 pseudogene	0.5694	3
GABARAP	GABA type A receptor-associated protein	0.5454	59
LAMP3	Lysosomal associated membrane protein 3	0.5448	3
CRLF2	Cytokine receptor like factor 2	0.5312	3
NUB1	Negative regulator of ubiquitin like proteins 1	0.5196	3
CCL22	C-C motif chemokine ligand 22	0.5186	3
EIF4EBP3	Eukaryotic translation initiation factor 4E binding protein 3	0.5181	59
SYNGR2	Synaptogyrin 2	0.5176	3
CCL17	C-C motif chemokine ligand 17	0.5159	3
AC114490.2	Novel protein	0.5149	1
PSMD9	Proteasome 26S subunit, non-ATPase 9	0.5086	59
ACOT2	Acyl-CoA thioesterase 2	0.5078	59
FOXD4L1	Forkhead box D4 like 1	0.5066	3
TRAFD1	TRAF-type zinc finger domain containing 1	0.5028	3

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.7 nTPM
Breast	19.8 nTPM
Adipose tissue	13.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	28.2 nTPM
Lung	28.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	13.6 nTPM
Breast	22.8 nTPM
Bone marrow	18.8 nTPM
Spleen	16.2 nTPM
Colon	16.0 nTPM
Kidney	14.3 nTPM
PBMC	12.9 nTPM
Lymph node	10.4 nTPM
Adipose tissue	9.0 nTPM
Stomach	8.6 nTPM
Liver	7.1 nTPM

Dendritic cells	14.0 nTPM
Breast	21.1 nTPM
PBMC	12.0 nTPM
Adipose tissue	9.0 nTPM

Endothelial cells	8.0 nTPM
Breast	18.8 nTPM
Heart muscle	14.3 nTPM
Lung	12.5 nTPM
Esophagus	11.1 nTPM
Liver	9.2 nTPM
Pancreas	7.7 nTPM
Placenta	6.8 nTPM
Skin	6.4 nTPM
Eye	5.7 nTPM
Testis	5.7 nTPM
Skeletal muscle	5.0 nTPM
Endometrium	4.3 nTPM
Ovary	3.1 nTPM
Prostate	1.7 nTPM

Fibroblasts	8.6 nTPM
Esophagus	20.3 nTPM
Breast	15.2 nTPM
Adipose tissue	13.5 nTPM
Stomach	10.4 nTPM
Placenta	8.6 nTPM
Heart muscle	8.5 nTPM
Skin	7.1 nTPM
Lung	4.5 nTPM
Skeletal muscle	3.8 nTPM
Ovary	1.8 nTPM
Prostate	0.9 nTPM

Intestinal goblet cells	19.3 nTPM
Rectum	22.8 nTPM
Small intestine	17.9 nTPM
Colon	17.2 nTPM

Macrophages	10.0 nTPM
Pancreas	20.4 nTPM
Lung	19.8 nTPM
Spleen	16.5 nTPM
Bone marrow	15.0 nTPM
Breast	14.8 nTPM
Esophagus	14.2 nTPM
Adipose tissue	11.1 nTPM
Kidney	9.9 nTPM
Stomach	5.9 nTPM
Testis	5.8 nTPM
Endometrium	5.4 nTPM
Skeletal muscle	4.2 nTPM
Ovary	4.2 nTPM
Prostate	2.2 nTPM
PBMC	0.0 nTPM

Paneth cells	24.2 nTPM
Colon	26.4 nTPM
Small intestine	26.3 nTPM
Rectum	19.8 nTPM

Plasma cells	14.6 nTPM
Esophagus	18.4 nTPM
Stomach	16.2 nTPM
Spleen	15.5 nTPM
Bone marrow	14.8 nTPM
Adipose tissue	7.8 nTPM

Respiratory ciliated cells	11.2 nTPM
Lung	11.7 nTPM
Bronchus	10.7 nTPM

Smooth muscle cells	6.8 nTPM
Breast	13.0 nTPM
Pancreas	12.8 nTPM
Heart muscle	11.4 nTPM
Adipose tissue	9.3 nTPM
Esophagus	7.8 nTPM
Skin	4.9 nTPM
Endometrium	4.8 nTPM
Skeletal muscle	3.1 nTPM
Bronchus	2.9 nTPM
Ovary	2.9 nTPM
Prostate	2.2 nTPM

T-cells	11.2 nTPM
Esophagus	19.7 nTPM
Lung	18.2 nTPM
Colon	18.1 nTPM
Bone marrow	17.2 nTPM
Liver	15.7 nTPM
Breast	15.1 nTPM
Stomach	12.0 nTPM
Spleen	11.2 nTPM
Skin	10.5 nTPM
PBMC	10.4 nTPM
Kidney	10.2 nTPM
Lymph node	10.0 nTPM
Adipose tissue	9.2 nTPM
Endometrium	6.3 nTPM
Ovary	4.5 nTPM
Skeletal muscle	2.5 nTPM
Prostate	0.0 nTPM

Basal prostatic cells	2.3 nTPM
Prostate	2.3 nTPM

Basal respiratory cells	6.9 nTPM
Bronchus	6.9 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Undifferentiated cells	17.3 nTPM
Small intestine	22.1 nTPM
Rectum	17.8 nTPM
Colon	12.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC