Single cell type - MCM5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MCM5
Gene descriptionⁱ Full gene name according to HGNC.	Minichromosome maintenance complex component 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts, monocytes, Erythroid cells, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, monocytes, Erythroid cells, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MCM5 is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MCM2	Minichromosome maintenance complex component 2	0.7538	12
RFC2	Replication factor C subunit 2	0.6544	12
PARP1	Poly(ADP-ribose) polymerase 1	0.6385	47
MCM3	Minichromosome maintenance complex component 3	0.6334	12
ERAL1	Era like 12S mitochondrial rRNA chaperone 1	0.6303	3
CSF2RA	Colony stimulating factor 2 receptor subunit alpha	0.6224	3
TOMM34	Translocase of outer mitochondrial membrane 34	0.6192	47
HMGN2	High mobility group nucleosomal binding domain 2	0.6049	12
CCR7	C-C motif chemokine receptor 7	0.5999	3
RMI2	RecQ mediated genome instability 2	0.5942	47
FLOT2	Flotillin 2	0.5611	47
FOXD4L1	Forkhead box D4 like 1	0.5550	3
NXPH4	Neurexophilin 4	0.5540	47
CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1	0.5512	47
ZNF726	Zinc finger protein 726	0.5498	12

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.1 nTPM
Adipose tissue	9.0 nTPM
Breast	7.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	7.3 nTPM
Lung	7.3 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	49.5 nTPM
Liver	104.5 nTPM
Stomach	60.0 nTPM
Colon	57.5 nTPM
Kidney	57.1 nTPM
Adipose tissue	52.7 nTPM
Spleen	39.1 nTPM
PBMC	38.6 nTPM
Lymph node	36.5 nTPM
Bone marrow	36.0 nTPM
Breast	13.4 nTPM

Dendritic cells	30.4 nTPM
PBMC	59.8 nTPM
Adipose tissue	18.9 nTPM
Breast	12.4 nTPM

Endothelial cells	11.8 nTPM
Ovary	25.8 nTPM
Eye	19.4 nTPM
Placenta	19.4 nTPM
Pancreas	19.3 nTPM
Testis	13.6 nTPM
Endometrium	11.0 nTPM
Skeletal muscle	10.5 nTPM
Esophagus	9.7 nTPM
Skin	8.3 nTPM
Breast	7.7 nTPM
Prostate	6.4 nTPM
Lung	6.2 nTPM
Liver	5.5 nTPM
Heart muscle	2.2 nTPM

Fibroblasts	11.2 nTPM
Ovary	40.7 nTPM
Placenta	28.1 nTPM
Adipose tissue	9.5 nTPM
Esophagus	7.7 nTPM
Stomach	7.4 nTPM
Skeletal muscle	7.2 nTPM
Skin	6.0 nTPM
Breast	5.5 nTPM
Prostate	4.5 nTPM
Heart muscle	4.4 nTPM
Lung	2.2 nTPM

Intestinal goblet cells	16.6 nTPM
Small intestine	25.8 nTPM
Colon	14.3 nTPM
Rectum	9.6 nTPM

Macrophages	28.4 nTPM
Pancreas	48.5 nTPM
Adipose tissue	38.3 nTPM
Testis	36.6 nTPM
Endometrium	35.6 nTPM
Bone marrow	35.0 nTPM
Breast	33.5 nTPM
Skeletal muscle	28.4 nTPM
Stomach	26.4 nTPM
Lung	26.3 nTPM
Kidney	25.7 nTPM
Prostate	24.1 nTPM
Ovary	24.0 nTPM
Spleen	22.8 nTPM
Esophagus	20.4 nTPM
PBMC	0.0 nTPM

Paneth cells	8.6 nTPM
Rectum	15.0 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	49.3 nTPM
Bone marrow	107.1 nTPM
Spleen	103.7 nTPM
Stomach	19.9 nTPM
Adipose tissue	9.7 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	4.8 nTPM
Lung	5.8 nTPM
Bronchus	3.8 nTPM

Smooth muscle cells	14.5 nTPM
Pancreas	45.4 nTPM
Ovary	36.1 nTPM
Endometrium	16.6 nTPM
Adipose tissue	13.1 nTPM
Skeletal muscle	11.3 nTPM
Esophagus	10.9 nTPM
Skin	7.3 nTPM
Prostate	7.2 nTPM
Breast	6.5 nTPM
Heart muscle	2.8 nTPM
Bronchus	1.9 nTPM

T-cells	19.4 nTPM
Colon	33.7 nTPM
Esophagus	32.8 nTPM
Lung	30.4 nTPM
Liver	25.1 nTPM
Stomach	24.9 nTPM
Bone marrow	24.7 nTPM
Kidney	23.3 nTPM
Lymph node	19.2 nTPM
Spleen	18.4 nTPM
Adipose tissue	15.3 nTPM
Endometrium	14.4 nTPM
PBMC	14.2 nTPM
Skeletal muscle	14.2 nTPM
Skin	13.3 nTPM
Ovary	11.1 nTPM
Breast	9.8 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	10.6 nTPM
Skin	10.6 nTPM

Basal respiratory cells	12.1 nTPM
Bronchus	12.1 nTPM

Cytotrophoblasts	147.8 nTPM
Placenta	147.8 nTPM

Distal enterocytes	12.0 nTPM
Colon	19.8 nTPM
Rectum	4.1 nTPM

Undifferentiated cells	34.6 nTPM
Small intestine	47.6 nTPM
Colon	37.0 nTPM
Rectum	19.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC