Single cell type - ACO2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACO2
Gene descriptionⁱ Full gene name according to HGNC.	Aconitase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Citric acid cycle related proteins Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACO2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UGT2A3	UDP glucuronosyltransferase family 2 member A3	0.6898	45
SLC13A2	Solute carrier family 13 member 2	0.6790	67
PBLD	Phenazine biosynthesis like protein domain containing	0.6731	67
FAM151A	Family with sequence similarity 151 member A	0.6672	67
SLC34A3	Solute carrier family 34 member 3	0.6602	67
CMBL	Carboxymethylenebutenolidase homolog	0.6464	67
KCNK5	Potassium two pore domain channel subfamily K member 5	0.6443	67
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.6439	67
SLC39A5	Solute carrier family 39 member 5	0.6336	45
PCK1	Phosphoenolpyruvate carboxykinase 1	0.6270	67
PEPD	Peptidase D	0.6243	67
TINAG	Tubulointerstitial nephritis antigen	0.6240	67
SMIM24	Small integral membrane protein 24	0.6234	67
ANKS4B	Ankyrin repeat and sterile alpha motif domain containing 4B	0.6163	45
SLC5A12	Solute carrier family 5 member 12	0.6159	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.3 nTPM
Breast	28.8 nTPM
Adipose tissue	23.9 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	31.8 nTPM
Lung	31.8 nTPM

Astrocytes	45.4 nTPM
Brain	45.4 nTPM

B-cells	49.4 nTPM
Liver	93.5 nTPM
Kidney	57.1 nTPM
Stomach	50.9 nTPM
PBMC	49.9 nTPM
Colon	46.4 nTPM
Spleen	46.4 nTPM
Bone marrow	40.9 nTPM
Breast	40.2 nTPM
Lymph node	37.7 nTPM
Adipose tissue	31.5 nTPM

Dendritic cells	33.3 nTPM
PBMC	47.8 nTPM
Adipose tissue	26.7 nTPM
Breast	25.5 nTPM

Endothelial cells	26.1 nTPM
Pancreas	42.5 nTPM
Placenta	41.5 nTPM
Eye	38.8 nTPM
Ovary	34.2 nTPM
Lung	31.2 nTPM
Skeletal muscle	25.0 nTPM
Testis	24.9 nTPM
Prostate	24.5 nTPM
Breast	24.2 nTPM
Endometrium	22.6 nTPM
Liver	18.3 nTPM
Skin	15.3 nTPM
Esophagus	15.0 nTPM
Heart muscle	7.0 nTPM

Fibroblasts	24.0 nTPM
Ovary	37.0 nTPM
Placenta	36.1 nTPM
Adipose tissue	28.0 nTPM
Lung	26.8 nTPM
Prostate	26.0 nTPM
Skeletal muscle	25.7 nTPM
Esophagus	25.6 nTPM
Stomach	23.7 nTPM
Breast	19.2 nTPM
Skin	13.6 nTPM
Heart muscle	2.3 nTPM

Intestinal goblet cells	99.1 nTPM
Colon	116.5 nTPM
Rectum	98.3 nTPM
Small intestine	82.4 nTPM

Macrophages	39.2 nTPM
Pancreas	97.0 nTPM
Kidney	54.4 nTPM
Bone marrow	47.5 nTPM
Ovary	47.3 nTPM
Adipose tissue	43.6 nTPM
Prostate	41.3 nTPM
Lung	37.4 nTPM
Testis	36.6 nTPM
Skeletal muscle	35.1 nTPM
Breast	30.7 nTPM
Stomach	29.4 nTPM
Spleen	27.9 nTPM
Endometrium	26.3 nTPM
Esophagus	20.4 nTPM
PBMC	13.6 nTPM

Paneth cells	103.5 nTPM
Colon	121.9 nTPM
Rectum	94.7 nTPM
Small intestine	93.9 nTPM

Plasma cells	63.2 nTPM
Spleen	97.4 nTPM
Stomach	78.4 nTPM
Bone marrow	77.4 nTPM
Esophagus	36.9 nTPM
Adipose tissue	25.8 nTPM

Respiratory ciliated cells	59.2 nTPM
Bronchus	76.1 nTPM
Lung	42.3 nTPM

Smooth muscle cells	38.4 nTPM
Bronchus	65.9 nTPM
Pancreas	58.0 nTPM
Ovary	53.0 nTPM
Skeletal muscle	46.5 nTPM
Prostate	42.5 nTPM
Breast	35.4 nTPM
Esophagus	32.5 nTPM
Adipose tissue	30.5 nTPM
Skin	30.0 nTPM
Endometrium	25.2 nTPM
Heart muscle	2.8 nTPM

T-cells	30.7 nTPM
Kidney	53.4 nTPM
Colon	49.4 nTPM
Stomach	41.7 nTPM
Prostate	37.9 nTPM
Lung	36.5 nTPM
PBMC	33.5 nTPM
Liver	32.2 nTPM
Bone marrow	31.0 nTPM
Spleen	30.5 nTPM
Skeletal muscle	29.3 nTPM
Breast	26.3 nTPM
Adipose tissue	26.1 nTPM
Lymph node	24.4 nTPM
Skin	22.6 nTPM
Ovary	17.8 nTPM
Endometrium	15.7 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	18.7 nTPM
Skin	18.7 nTPM

Basal prostatic cells	54.5 nTPM
Prostate	54.5 nTPM

Basal respiratory cells	102.7 nTPM
Bronchus	102.7 nTPM

Basal squamous epithelial cells	31.3 nTPM
Esophagus	31.3 nTPM

Undifferentiated cells	113.6 nTPM
Colon	125.4 nTPM
Rectum	124.9 nTPM
Small intestine	90.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC