Single cell type - MAPRE1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAPRE1
Gene descriptionⁱ Full gene name according to HGNC.	Microtubule associated protein RP/EB family member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAPRE1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HSPA8	Heat shock protein family A (Hsp70) member 8	0.6862	22
AHSA1	Activator of HSP90 ATPase activity 1	0.6717	22
HSPE1	Heat shock protein family E (Hsp10) member 1	0.6525	22
UBE2D3	Ubiquitin conjugating enzyme E2 D3	0.6448	10
HSPD1	Heat shock protein family D (Hsp60) member 1	0.6273	22
CCT4	Chaperonin containing TCP1 subunit 4	0.5907	10
FKBP4	FKBP prolyl isomerase 4	0.5862	22
PTGES3	Prostaglandin E synthase 3	0.5840	22
CNBP	CCHC-type zinc finger nucleic acid binding protein	0.5779	10
RHEB	Ras homolog, mTORC1 binding	0.5732	10
COA7	Cytochrome c oxidase assembly factor 7 (putative)	0.5715	10
HSPA4	Heat shock protein family A (Hsp70) member 4	0.5683	10
UBE2B	Ubiquitin conjugating enzyme E2 B	0.5667	10
HNRNPF	Heterogeneous nuclear ribonucleoprotein F	0.5615	10
HNRNPK	Heterogeneous nuclear ribonucleoprotein K	0.5613	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	71.6 nTPM
Adipose tissue	74.9 nTPM
Breast	68.3 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	30.2 nTPM
Lung	30.2 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	67.0 nTPM
Adipose tissue	118.9 nTPM
Colon	91.1 nTPM
Liver	89.5 nTPM
Stomach	78.1 nTPM
Spleen	68.2 nTPM
Lymph node	55.4 nTPM
Breast	48.1 nTPM
Bone marrow	46.6 nTPM
Kidney	38.1 nTPM
PBMC	35.7 nTPM

Dendritic cells	82.0 nTPM
Adipose tissue	111.7 nTPM
Breast	78.4 nTPM
PBMC	55.8 nTPM

Endothelial cells	64.8 nTPM
Prostate	154.5 nTPM
Skin	85.9 nTPM
Ovary	76.7 nTPM
Placenta	69.9 nTPM
Pancreas	69.5 nTPM
Breast	63.2 nTPM
Eye	59.1 nTPM
Esophagus	55.5 nTPM
Endometrium	54.6 nTPM
Skeletal muscle	54.3 nTPM
Testis	52.4 nTPM
Lung	43.7 nTPM
Liver	38.5 nTPM
Heart muscle	29.1 nTPM

Enteroendocrine cells	71.5 nTPM
Colon	106.6 nTPM
Rectum	36.4 nTPM

Fibroblasts	61.4 nTPM
Prostate	177.5 nTPM
Skin	67.3 nTPM
Placenta	66.9 nTPM
Stomach	63.9 nTPM
Ovary	55.7 nTPM
Adipose tissue	48.6 nTPM
Esophagus	46.1 nTPM
Skeletal muscle	41.7 nTPM
Lung	40.2 nTPM
Breast	35.3 nTPM
Heart muscle	32.6 nTPM

Intestinal goblet cells	43.6 nTPM
Colon	59.3 nTPM
Rectum	37.4 nTPM
Small intestine	34.0 nTPM

Macrophages	99.5 nTPM
Adipose tissue	153.5 nTPM
Prostate	145.6 nTPM
Spleen	125.5 nTPM
Esophagus	122.8 nTPM
Pancreas	117.4 nTPM
Testis	96.4 nTPM
PBMC	95.5 nTPM
Ovary	88.8 nTPM
Kidney	84.7 nTPM
Breast	84.4 nTPM
Stomach	82.1 nTPM
Skeletal muscle	78.0 nTPM
Bone marrow	76.2 nTPM
Lung	72.9 nTPM
Endometrium	69.0 nTPM

Paneth cells	40.5 nTPM
Colon	42.8 nTPM
Rectum	41.1 nTPM
Small intestine	37.6 nTPM

Plasma cells	71.1 nTPM
Stomach	98.5 nTPM
Spleen	86.2 nTPM
Bone marrow	64.2 nTPM
Adipose tissue	63.8 nTPM
Esophagus	43.0 nTPM

Respiratory ciliated cells	39.4 nTPM
Bronchus	45.2 nTPM
Lung	33.5 nTPM

Smooth muscle cells	102.8 nTPM
Bronchus	297.3 nTPM
Prostate	156.3 nTPM
Pancreas	132.1 nTPM
Skin	112.3 nTPM
Ovary	77.5 nTPM
Skeletal muscle	65.4 nTPM
Esophagus	65.2 nTPM
Adipose tissue	58.1 nTPM
Breast	56.2 nTPM
Endometrium	56.0 nTPM
Heart muscle	54.3 nTPM

Basal keratinocytes	132.8 nTPM
Skin	132.8 nTPM

Basal prostatic cells	194.4 nTPM
Prostate	194.4 nTPM

Basal squamous epithelial cells	62.0 nTPM
Esophagus	62.0 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

T-cells	89.8 nTPM
Prostate	198.9 nTPM
Skin	146.0 nTPM
Adipose tissue	131.6 nTPM
Colon	119.8 nTPM
Stomach	108.3 nTPM
Kidney	87.6 nTPM
Spleen	81.6 nTPM
Ovary	77.9 nTPM
Breast	77.5 nTPM
Endometrium	71.2 nTPM
Lymph node	68.7 nTPM
Bone marrow	63.2 nTPM
Skeletal muscle	61.7 nTPM
Liver	61.6 nTPM
Lung	60.7 nTPM
PBMC	58.3 nTPM
Esophagus	52.4 nTPM

Undifferentiated cells	44.4 nTPM
Colon	62.5 nTPM
Rectum	36.8 nTPM
Small intestine	33.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC