Single cell type - UBE2D3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBE2D3
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin conjugating enzyme E2 D3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBE2D3 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBE2B	Ubiquitin conjugating enzyme E2 B	0.6970	10
MAPRE1	Microtubule associated protein RP/EB family member 1	0.6448	10
DNPEP	Aspartyl aminopeptidase	0.6315	10
PSMD12	Proteasome 26S subunit, non-ATPase 12	0.5831	10
EIF3H	Eukaryotic translation initiation factor 3 subunit H	0.5819	10
TUBA4A	Tubulin alpha 4a	0.5775	10
RHEB	Ras homolog, mTORC1 binding	0.5711	10
CLK3	CDC like kinase 3	0.5668	10
NACA2	Nascent polypeptide associated complex subunit alpha 2	0.5628	10
PFDN2	Prefoldin subunit 2	0.5611	10
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.5541	10
EIF1	Eukaryotic translation initiation factor 1	0.5501	32
CNBP	CCHC-type zinc finger nucleic acid binding protein	0.5496	10
TBRG1	Transforming growth factor beta regulator 1	0.5495	10
YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	0.5478	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	303.4 nTPM
Adipose tissue	391.3 nTPM
Breast	215.5 nTPM

Alveolar cells type 1	166.7 nTPM
Lung	166.7 nTPM

Alveolar cells type 2	193.1 nTPM
Lung	193.1 nTPM

Astrocytes	98.9 nTPM
Brain	98.9 nTPM

B-cells	291.7 nTPM
Adipose tissue	411.1 nTPM
Colon	386.6 nTPM
Spleen	367.2 nTPM
Lymph node	300.7 nTPM
Stomach	299.8 nTPM
Liver	294.4 nTPM
PBMC	248.4 nTPM
Bone marrow	209.3 nTPM
Breast	204.6 nTPM
Kidney	195.2 nTPM

Basal squamous epithelial cells	233.9 nTPM
Esophagus	233.9 nTPM

Dendritic cells	317.4 nTPM
Breast	379.4 nTPM
Adipose tissue	377.6 nTPM
PBMC	195.3 nTPM

Endothelial cells	344.0 nTPM
Prostate	885.0 nTPM
Skin	756.7 nTPM
Pancreas	389.9 nTPM
Skeletal muscle	349.2 nTPM
Endometrium	304.1 nTPM
Placenta	301.2 nTPM
Esophagus	283.6 nTPM
Breast	283.4 nTPM
Testis	248.0 nTPM
Eye	226.6 nTPM
Lung	224.6 nTPM
Ovary	201.2 nTPM
Liver	182.5 nTPM
Heart muscle	179.7 nTPM

Enteroendocrine cells	240.8 nTPM
Colon	302.0 nTPM
Rectum	179.6 nTPM

Erythroid cells	348.7 nTPM
Liver	481.3 nTPM
Bone marrow	216.1 nTPM

Fibroblasts	286.0 nTPM
Prostate	680.6 nTPM
Skin	498.5 nTPM
Stomach	271.7 nTPM
Placenta	245.4 nTPM
Esophagus	244.3 nTPM
Lung	242.4 nTPM
Adipose tissue	231.6 nTPM
Heart muscle	190.5 nTPM
Ovary	185.3 nTPM
Breast	184.6 nTPM
Skeletal muscle	170.9 nTPM

Intestinal goblet cells	283.8 nTPM
Colon	436.0 nTPM
Rectum	214.6 nTPM
Small intestine	200.7 nTPM

Macrophages	415.1 nTPM
Prostate	787.6 nTPM
Adipose tissue	708.2 nTPM
Stomach	518.6 nTPM
Spleen	514.2 nTPM
Endometrium	441.1 nTPM
Kidney	404.7 nTPM
Pancreas	387.9 nTPM
Skeletal muscle	377.1 nTPM
Testis	340.5 nTPM
Ovary	333.9 nTPM
Esophagus	319.5 nTPM
Breast	313.4 nTPM
Bone marrow	302.4 nTPM
Lung	259.4 nTPM
PBMC	218.3 nTPM

Paneth cells	347.2 nTPM
Colon	527.0 nTPM
Small intestine	262.8 nTPM
Rectum	251.7 nTPM

Plasma cells	296.4 nTPM
Spleen	397.8 nTPM
Stomach	310.4 nTPM
Esophagus	277.2 nTPM
Bone marrow	248.9 nTPM
Adipose tissue	247.7 nTPM

Cholangiocytes	193.0 nTPM
Liver	193.0 nTPM

Collecting duct cells	139.8 nTPM
Kidney	139.8 nTPM

Cone photoreceptor cells	125.1 nTPM
Eye	125.1 nTPM

Cytotrophoblasts	311.5 nTPM
Placenta	311.5 nTPM

Respiratory ciliated cells	242.4 nTPM
Bronchus	277.8 nTPM
Lung	206.9 nTPM

Smooth muscle cells	531.9 nTPM
Bronchus	2857.6 nTPM
Prostate	678.0 nTPM
Skin	551.9 nTPM
Pancreas	436.0 nTPM
Skeletal muscle	220.3 nTPM
Endometrium	211.3 nTPM
Ovary	195.0 nTPM
Adipose tissue	185.0 nTPM
Esophagus	184.5 nTPM
Heart muscle	172.5 nTPM
Breast	159.2 nTPM

T-cells	382.5 nTPM
Prostate	686.4 nTPM
Skin	605.1 nTPM
Adipose tissue	508.2 nTPM
Spleen	455.8 nTPM
Lymph node	429.3 nTPM
Colon	406.7 nTPM
Endometrium	384.7 nTPM
Breast	379.1 nTPM
Kidney	376.4 nTPM
Stomach	370.8 nTPM
PBMC	322.8 nTPM
Liver	319.2 nTPM
Skeletal muscle	301.0 nTPM
Ovary	287.0 nTPM
Bone marrow	263.1 nTPM
Esophagus	242.3 nTPM
Lung	164.0 nTPM

Undifferentiated cells	268.2 nTPM
Colon	378.7 nTPM
Small intestine	231.2 nTPM
Rectum	194.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC