Single cell type - LPIN2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LPIN2
Gene descriptionⁱ Full gene name according to HGNC.	Lipin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells, Cholangiocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells, Cholangiocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LPIN2 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TLL2	Tolloid like 2	0.8163	40
KYAT1	Kynurenine aminotransferase 1	0.8001	40
SPRR2F	Small proline rich protein 2F	0.7999	40
LRAT	Lecithin retinol acyltransferase	0.7983	40
HS6ST1	Heparan sulfate 6-O-sulfotransferase 1	0.7981	40
INHBB	Inhibin subunit beta B	0.7831	40
FST	Follistatin	0.7768	40
DHH	Desert hedgehog signaling molecule	0.7658	40
NR5A2	Nuclear receptor subfamily 5 group A member 2	0.7623	40
LMBR1L	Limb development membrane protein 1 like	0.7602	40
SLC47A1	Solute carrier family 47 member 1	0.7583	40
CEACAM21	CEA cell adhesion molecule 21	0.7564	40
GREB1	Growth regulating estrogen receptor binding 1	0.7562	40
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	0.7542	40
MRAP	Melanocortin 2 receptor accessory protein	0.7476	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.7 nTPM
Breast	18.0 nTPM
Adipose tissue	17.5 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	44.0 nTPM
Lung	44.0 nTPM

Astrocytes	55.2 nTPM
Brain	55.2 nTPM

B-cells	20.4 nTPM
Colon	35.1 nTPM
Adipose tissue	34.5 nTPM
Stomach	28.2 nTPM
Kidney	23.8 nTPM
Breast	17.3 nTPM
Lymph node	16.9 nTPM
Spleen	14.6 nTPM
PBMC	12.9 nTPM
Bone marrow	11.5 nTPM
Liver	9.2 nTPM

Dendritic cells	41.9 nTPM
Adipose tissue	71.0 nTPM
Breast	46.7 nTPM
PBMC	8.0 nTPM

Endothelial cells	18.9 nTPM
Eye	37.2 nTPM
Endometrium	37.1 nTPM
Liver	32.1 nTPM
Prostate	26.7 nTPM
Testis	25.8 nTPM
Heart muscle	21.9 nTPM
Lung	18.7 nTPM
Ovary	16.5 nTPM
Breast	12.4 nTPM
Placenta	9.7 nTPM
Skin	7.7 nTPM
Skeletal muscle	7.7 nTPM
Esophagus	7.1 nTPM
Pancreas	3.9 nTPM

Erythroid cells	138.1 nTPM
Liver	229.9 nTPM
Bone marrow	46.3 nTPM

Fibroblasts	25.4 nTPM
Adipose tissue	42.4 nTPM
Skeletal muscle	32.7 nTPM
Prostate	31.3 nTPM
Stomach	31.2 nTPM
Breast	29.7 nTPM
Placenta	28.1 nTPM
Lung	25.7 nTPM
Ovary	20.8 nTPM
Esophagus	19.5 nTPM
Skin	13.5 nTPM
Heart muscle	4.5 nTPM

Intestinal goblet cells	36.8 nTPM
Colon	49.4 nTPM
Small intestine	35.1 nTPM
Rectum	26.1 nTPM

Macrophages	31.1 nTPM
Ovary	76.3 nTPM
Breast	61.3 nTPM
Testis	40.7 nTPM
Adipose tissue	35.3 nTPM
Spleen	33.2 nTPM
Bone marrow	30.0 nTPM
Esophagus	29.9 nTPM
Skeletal muscle	28.8 nTPM
Prostate	27.5 nTPM
Lung	26.6 nTPM
Endometrium	26.3 nTPM
Kidney	18.9 nTPM
Stomach	17.6 nTPM
PBMC	13.6 nTPM
Pancreas	0.0 nTPM

Paneth cells	21.6 nTPM
Colon	46.1 nTPM
Small intestine	11.3 nTPM
Rectum	7.6 nTPM

Plasma cells	16.1 nTPM
Adipose tissue	58.6 nTPM
Stomach	11.2 nTPM
Spleen	5.6 nTPM
Bone marrow	5.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	17.1 nTPM
Lung	23.3 nTPM
Bronchus	10.8 nTPM

Smooth muscle cells	20.1 nTPM
Ovary	66.6 nTPM
Endometrium	32.3 nTPM
Breast	21.6 nTPM
Adipose tissue	20.6 nTPM
Prostate	20.0 nTPM
Esophagus	17.0 nTPM
Pancreas	13.3 nTPM
Skeletal muscle	12.8 nTPM
Skin	9.7 nTPM
Bronchus	5.6 nTPM
Heart muscle	2.1 nTPM

Basal prostatic cells	9.8 nTPM
Prostate	9.8 nTPM

Basal respiratory cells	8.5 nTPM
Bronchus	8.5 nTPM

Basal squamous epithelial cells	5.7 nTPM
Esophagus	5.7 nTPM

Cholangiocytes	154.4 nTPM
Liver	154.4 nTPM

T-cells	58.9 nTPM
Adipose tissue	130.2 nTPM
Colon	106.4 nTPM
Skeletal muscle	72.9 nTPM
Stomach	71.6 nTPM
PBMC	67.0 nTPM
Breast	60.8 nTPM
Kidney	59.6 nTPM
Ovary	57.8 nTPM
Endometrium	56.6 nTPM
Bone marrow	56.3 nTPM
Spleen	55.1 nTPM
Lymph node	48.9 nTPM
Lung	47.1 nTPM
Liver	46.0 nTPM
Esophagus	26.2 nTPM
Prostate	23.6 nTPM
Skin	14.3 nTPM

Undifferentiated cells	14.0 nTPM
Rectum	16.0 nTPM
Small intestine	15.0 nTPM
Colon	11.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC