Single cell type - XIAP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	XIAP
Gene descriptionⁱ Full gene name according to HGNC.	X-linked inhibitor of apoptosis
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

XIAP is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGSF9	Immunoglobulin superfamily member 9	0.6057	46
TMEM127	Transmembrane protein 127	0.5922	53
AP3S2	Adaptor related protein complex 3 subunit sigma 2	0.5729	53
PEX26	Peroxisomal biogenesis factor 26	0.5636	53
STX3	Syntaxin 3	0.5580	9
CNNM4	Cyclin and CBS domain divalent metal cation transport mediator 4	0.5539	53
PDCD6IP	Programmed cell death 6 interacting protein	0.5371	53
CKB	Creatine kinase B	0.5316	53
NR2F6	Nuclear receptor subfamily 2 group F member 6	0.5313	53
MUC20	Mucin 20, cell surface associated	0.5284	26
ENTPD5	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive)	0.5255	53
LRRC19	Leucine rich repeat containing 19	0.5239	53
SHROOM1	Shroom family member 1	0.5236	53
MON1B	MON1 homolog B, secretory trafficking associated	0.5129	14
PARP4	Poly(ADP-ribose) polymerase family member 4	0.5083	11

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.0 nTPM
Adipose tissue	60.2 nTPM
Breast	39.7 nTPM

Alveolar cells type 1	80.1 nTPM
Lung	80.1 nTPM

Alveolar cells type 2	91.6 nTPM
Lung	91.6 nTPM

Astrocytes	26.4 nTPM
Brain	26.4 nTPM

B-cells	42.1 nTPM
Adipose tissue	61.1 nTPM
Bone marrow	57.2 nTPM
PBMC	51.3 nTPM
Spleen	41.5 nTPM
Lymph node	40.7 nTPM
Colon	36.7 nTPM
Stomach	35.4 nTPM
Liver	35.1 nTPM
Breast	33.4 nTPM
Kidney	28.5 nTPM

Dendritic cells	41.7 nTPM
Adipose tissue	48.8 nTPM
PBMC	47.8 nTPM
Breast	28.4 nTPM

Endothelial cells	55.0 nTPM
Lung	127.9 nTPM
Liver	88.1 nTPM
Prostate	68.6 nTPM
Ovary	56.7 nTPM
Skeletal muscle	54.9 nTPM
Heart muscle	54.8 nTPM
Endometrium	52.5 nTPM
Testis	49.5 nTPM
Eye	49.3 nTPM
Esophagus	40.8 nTPM
Breast	35.3 nTPM
Skin	32.8 nTPM
Pancreas	30.9 nTPM
Placenta	28.4 nTPM

Fibroblasts	38.4 nTPM
Heart muscle	54.0 nTPM
Skeletal muscle	52.8 nTPM
Lung	52.5 nTPM
Adipose tissue	52.0 nTPM
Prostate	42.6 nTPM
Esophagus	33.8 nTPM
Skin	30.8 nTPM
Breast	30.1 nTPM
Ovary	28.1 nTPM
Placenta	27.8 nTPM
Stomach	17.8 nTPM

Intestinal goblet cells	62.2 nTPM
Rectum	74.7 nTPM
Colon	60.8 nTPM
Small intestine	51.2 nTPM

Macrophages	44.2 nTPM
Lung	92.8 nTPM
Adipose tissue	68.3 nTPM
Spleen	63.2 nTPM
Prostate	52.7 nTPM
Pancreas	51.0 nTPM
Kidney	45.3 nTPM
Skeletal muscle	43.5 nTPM
Bone marrow	41.2 nTPM
Ovary	40.5 nTPM
Testis	40.1 nTPM
Stomach	38.1 nTPM
Endometrium	33.4 nTPM
Esophagus	26.8 nTPM
Breast	26.1 nTPM
PBMC	0.0 nTPM

Paneth cells	53.5 nTPM
Rectum	63.3 nTPM
Colon	56.0 nTPM
Small intestine	41.3 nTPM

Plasma cells	39.5 nTPM
Adipose tissue	52.9 nTPM
Stomach	49.9 nTPM
Bone marrow	36.2 nTPM
Spleen	33.8 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	50.6 nTPM
Lung	51.0 nTPM
Bronchus	50.1 nTPM

Smooth muscle cells	34.9 nTPM
Heart muscle	61.6 nTPM
Adipose tissue	53.7 nTPM
Skeletal muscle	42.6 nTPM
Endometrium	39.5 nTPM
Prostate	32.1 nTPM
Esophagus	27.9 nTPM
Ovary	26.7 nTPM
Skin	26.5 nTPM
Pancreas	26.1 nTPM
Breast	26.0 nTPM
Bronchus	20.8 nTPM

T-cells	40.8 nTPM
Esophagus	58.9 nTPM
Lung	57.7 nTPM
Prostate	56.8 nTPM
PBMC	55.2 nTPM
Skeletal muscle	47.3 nTPM
Adipose tissue	44.3 nTPM
Bone marrow	42.7 nTPM
Liver	42.5 nTPM
Endometrium	36.9 nTPM
Lymph node	36.5 nTPM
Spleen	36.4 nTPM
Kidney	35.6 nTPM
Colon	31.4 nTPM
Breast	30.5 nTPM
Skin	29.9 nTPM
Stomach	28.7 nTPM
Ovary	22.3 nTPM

Basal keratinocytes	26.6 nTPM
Skin	26.6 nTPM

Basal prostatic cells	36.3 nTPM
Prostate	36.3 nTPM

Basal respiratory cells	35.0 nTPM
Bronchus	35.0 nTPM

Collecting duct cells	53.3 nTPM
Kidney	53.3 nTPM

Undifferentiated cells	48.0 nTPM
Rectum	55.6 nTPM
Colon	50.6 nTPM
Small intestine	37.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC