Single cell type - TSC22D1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSC22D1
Gene descriptionⁱ Full gene name according to HGNC.	TSC22 domain family member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TSC22D1 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RNF11	Ring finger protein 11	0.5576	51
MAD2L1BP	MAD2L1 binding protein	0.5263	51
MAX	MYC associated factor X	0.4898	51
PDLIM1	PDZ and LIM domain 1	0.4800	53
CDKN1A	Cyclin dependent kinase inhibitor 1A	0.4722	7
SNAP23	Synaptosome associated protein 23	0.4471	51
RAB11B	RAB11B, member RAS oncogene family	0.4433	10
NT5C3A	5'-nucleotidase, cytosolic IIIA	0.4395	51
RSU1	Ras suppressor protein 1	0.4342	51
BPIFB3	BPI fold containing family B member 3	0.4314	51
RAB4A	RAB4A, member RAS oncogene family	0.4305	32
F2RL3	F2R like thrombin or trypsin receptor 3	0.4297	51
RAB27B	RAB27B, member RAS oncogene family	0.4200	51
SBDS	SBDS ribosome maturation factor	0.4147	31
SERTAD1	SERTA domain containing 1	0.4125	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	739.9 nTPM
Adipose tissue	884.9 nTPM
Breast	594.9 nTPM

Alveolar cells type 1	118.6 nTPM
Lung	118.6 nTPM

Alveolar cells type 2	368.2 nTPM
Lung	368.2 nTPM

Astrocytes	77.7 nTPM
Brain	77.7 nTPM

B-cells	21.4 nTPM
Kidney	42.9 nTPM
Colon	36.7 nTPM
Breast	34.7 nTPM
Lymph node	28.2 nTPM
Adipose tissue	20.6 nTPM
PBMC	17.1 nTPM
Liver	13.8 nTPM
Stomach	9.1 nTPM
Spleen	7.2 nTPM
Bone marrow	4.1 nTPM

Basal squamous epithelial cells	870.2 nTPM
Esophagus	870.2 nTPM

Dendritic cells	34.9 nTPM
Breast	56.2 nTPM
Adipose tissue	32.6 nTPM
PBMC	16.0 nTPM

Endothelial cells	643.0 nTPM
Skin	2113.4 nTPM
Prostate	1713.5 nTPM
Eye	1114.2 nTPM
Esophagus	680.6 nTPM
Breast	561.5 nTPM
Endometrium	526.9 nTPM
Testis	410.4 nTPM
Skeletal muscle	409.9 nTPM
Placenta	372.3 nTPM
Ovary	337.0 nTPM
Lung	268.2 nTPM
Heart muscle	246.4 nTPM
Pancreas	200.8 nTPM
Liver	46.7 nTPM

Enteroendocrine cells	225.0 nTPM
Colon	302.0 nTPM
Rectum	148.0 nTPM

Erythroid cells	118.9 nTPM
Liver	128.4 nTPM
Bone marrow	109.3 nTPM

Fibroblasts	234.3 nTPM
Prostate	485.9 nTPM
Breast	329.2 nTPM
Stomach	301.5 nTPM
Adipose tissue	279.2 nTPM
Esophagus	276.2 nTPM
Skin	248.6 nTPM
Lung	169.7 nTPM
Heart muscle	166.3 nTPM
Placenta	120.9 nTPM
Skeletal muscle	109.5 nTPM
Ovary	89.8 nTPM

Intestinal goblet cells	254.0 nTPM
Colon	422.4 nTPM
Rectum	171.3 nTPM
Small intestine	168.4 nTPM

Macrophages	218.4 nTPM
PBMC	2523.4 nTPM
Prostate	159.4 nTPM
Adipose tissue	157.2 nTPM
Ovary	105.6 nTPM
Breast	62.5 nTPM
Esophagus	50.4 nTPM
Lung	48.3 nTPM
Endometrium	44.4 nTPM
Skeletal muscle	24.3 nTPM
Kidney	22.7 nTPM
Testis	22.6 nTPM
Pancreas	20.4 nTPM
Stomach	17.6 nTPM
Spleen	11.4 nTPM
Bone marrow	6.2 nTPM

Paneth cells	339.6 nTPM
Colon	721.3 nTPM
Rectum	158.7 nTPM
Small intestine	138.9 nTPM

Plasma cells	17.2 nTPM
Adipose tissue	33.6 nTPM
Esophagus	30.7 nTPM
Stomach	16.3 nTPM
Bone marrow	3.3 nTPM
Spleen	2.2 nTPM

Cholangiocytes	97.2 nTPM
Liver	97.2 nTPM

Collecting duct cells	435.9 nTPM
Kidney	435.9 nTPM

Cone photoreceptor cells	114.7 nTPM
Eye	114.7 nTPM

Cytotrophoblasts	584.7 nTPM
Placenta	584.7 nTPM

Respiratory ciliated cells	265.8 nTPM
Lung	316.3 nTPM
Bronchus	215.3 nTPM

Smooth muscle cells	500.9 nTPM
Prostate	998.7 nTPM
Esophagus	829.5 nTPM
Breast	818.9 nTPM
Skin	615.5 nTPM
Bronchus	580.6 nTPM
Adipose tissue	561.9 nTPM
Skeletal muscle	381.0 nTPM
Heart muscle	355.2 nTPM
Endometrium	172.0 nTPM
Ovary	127.3 nTPM
Pancreas	69.7 nTPM

T-cells	65.0 nTPM
Prostate	610.7 nTPM
Skin	103.1 nTPM
Endometrium	65.3 nTPM
Breast	59.7 nTPM
Colon	39.9 nTPM
Lung	38.0 nTPM
Skeletal muscle	32.4 nTPM
Kidney	29.4 nTPM
Lymph node	20.1 nTPM
Esophagus	19.7 nTPM
PBMC	18.9 nTPM
Liver	17.2 nTPM
Adipose tissue	15.6 nTPM
Stomach	12.2 nTPM
Ovary	11.1 nTPM
Spleen	7.2 nTPM
Bone marrow	4.6 nTPM

Undifferentiated cells	273.6 nTPM
Colon	510.4 nTPM
Small intestine	165.5 nTPM
Rectum	144.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC