Single cell type - DCTN6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCTN6
Gene descriptionⁱ Full gene name according to HGNC.	Dynactin subunit 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DCTN6 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.96
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PGK1	Phosphoglycerate kinase 1	0.6744	26
SKP1	S-phase kinase associated protein 1	0.6489	39
MRPL50	Mitochondrial ribosomal protein L50	0.6162	26
C4orf3	Chromosome 4 open reading frame 3	0.6054	26
PTS	6-pyruvoyltetrahydropterin synthase	0.5948	16
MRPL13	Mitochondrial ribosomal protein L13	0.5869	26
ATP6V1E1	ATPase H+ transporting V1 subunit E1	0.5836	7
STRAP	Serine/threonine kinase receptor associated protein	0.5773	39
RBM8A	RNA binding motif protein 8A	0.5674	39
CYP24A1	Cytochrome P450 family 24 subfamily A member 1	0.5644	26
C11orf58	Chromosome 11 open reading frame 58	0.5485	39
NDUFS4	NADH:ubiquinone oxidoreductase subunit S4	0.5473	39
LDHA	Lactate dehydrogenase A	0.5442	16
SNRPB2	Small nuclear ribonucleoprotein polypeptide B2	0.5380	67
NDUFV2	NADH:ubiquinone oxidoreductase core subunit V2	0.5360	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	61.3 nTPM
Adipose tissue	64.9 nTPM
Breast	57.7 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	39.7 nTPM
Lung	39.7 nTPM

Astrocytes	19.9 nTPM
Brain	19.9 nTPM

B-cells	34.9 nTPM
Kidney	57.1 nTPM
Stomach	44.5 nTPM
Colon	43.2 nTPM
Liver	40.6 nTPM
Spleen	30.1 nTPM
PBMC	28.5 nTPM
Adipose tissue	28.5 nTPM
Breast	28.1 nTPM
Lymph node	27.9 nTPM
Bone marrow	20.4 nTPM

Dendritic cells	48.9 nTPM
Adipose tissue	76.0 nTPM
Breast	39.0 nTPM
PBMC	31.8 nTPM

Endothelial cells	58.7 nTPM
Pancreas	92.6 nTPM
Placenta	89.8 nTPM
Prostate	73.3 nTPM
Skin	64.9 nTPM
Liver	58.7 nTPM
Ovary	56.6 nTPM
Heart muscle	56.1 nTPM
Skeletal muscle	55.6 nTPM
Testis	55.1 nTPM
Eye	55.0 nTPM
Lung	53.0 nTPM
Breast	43.9 nTPM
Endometrium	34.9 nTPM
Esophagus	32.5 nTPM

Fibroblasts	56.6 nTPM
Placenta	105.7 nTPM
Adipose tissue	72.8 nTPM
Prostate	62.0 nTPM
Skin	59.4 nTPM
Stomach	52.0 nTPM
Skeletal muscle	51.2 nTPM
Breast	50.2 nTPM
Lung	45.8 nTPM
Esophagus	42.4 nTPM
Ovary	41.2 nTPM
Heart muscle	40.1 nTPM

Intestinal goblet cells	31.6 nTPM
Small intestine	36.5 nTPM
Colon	29.3 nTPM
Rectum	29.0 nTPM

Macrophages	43.2 nTPM
Adipose tissue	68.3 nTPM
Pancreas	66.4 nTPM
Kidney	62.8 nTPM
Lung	52.7 nTPM
Prostate	48.2 nTPM
Testis	47.7 nTPM
Ovary	44.5 nTPM
Breast	43.2 nTPM
Stomach	41.0 nTPM
Skeletal muscle	37.9 nTPM
Spleen	34.2 nTPM
Esophagus	29.9 nTPM
Endometrium	28.7 nTPM
Bone marrow	28.7 nTPM
PBMC	13.6 nTPM

Paneth cells	43.1 nTPM
Colon	56.0 nTPM
Small intestine	41.3 nTPM
Rectum	32.1 nTPM

Plasma cells	32.3 nTPM
Adipose tissue	41.9 nTPM
Stomach	40.5 nTPM
Spleen	39.4 nTPM
Bone marrow	21.4 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	71.6 nTPM
Bronchus	80.5 nTPM
Lung	62.7 nTPM

Smooth muscle cells	66.0 nTPM
Heart muscle	97.2 nTPM
Pancreas	85.0 nTPM
Skeletal muscle	73.4 nTPM
Ovary	72.7 nTPM
Adipose tissue	71.8 nTPM
Skin	71.1 nTPM
Prostate	70.0 nTPM
Breast	62.1 nTPM
Bronchus	45.9 nTPM
Esophagus	38.8 nTPM
Endometrium	38.1 nTPM

T-cells	59.8 nTPM
Adipose tissue	143.2 nTPM
Colon	117.8 nTPM
Skin	110.0 nTPM
Breast	78.9 nTPM
Stomach	70.7 nTPM
Lymph node	64.9 nTPM
Prostate	56.8 nTPM
Spleen	56.5 nTPM
Skeletal muscle	51.5 nTPM
Kidney	50.0 nTPM
PBMC	39.6 nTPM
Liver	37.3 nTPM
Lung	33.4 nTPM
Endometrium	31.4 nTPM
Ovary	28.9 nTPM
Bone marrow	26.5 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	57.2 nTPM
Skin	57.2 nTPM

Basal prostatic cells	91.3 nTPM
Prostate	91.3 nTPM

Basal respiratory cells	127.1 nTPM
Bronchus	127.1 nTPM

Cholangiocytes	47.1 nTPM
Liver	47.1 nTPM

Undifferentiated cells	33.0 nTPM
Colon	40.8 nTPM
Small intestine	30.6 nTPM
Rectum	27.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC