Single cell type - SNRPB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNRPB2
Gene descriptionⁱ Full gene name according to HGNC.	Small nuclear ribonucleoprotein polypeptide B2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNRPB2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATP6V1E1	ATPase H+ transporting V1 subunit E1	0.6108	7
MT1G	Metallothionein 1G	0.5707	67
LYG1	Lysozyme g1	0.5637	67
NDUFS4	NADH:ubiquinone oxidoreductase subunit S4	0.5554	39
LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	0.5539	67
SRP14	Signal recognition particle 14	0.5528	39
SUCLG1	Succinate-CoA ligase GDP/ADP-forming subunit alpha	0.5485	67
MT1H	Metallothionein 1H	0.5451	67
DCTN6	Dynactin subunit 6	0.5380	39
HJV	Hemojuvelin BMP co-receptor	0.5366	67
C11orf54	Chromosome 11 open reading frame 54	0.5337	67
DYNC1I2	Dynein cytoplasmic 1 intermediate chain 2	0.5331	7
MT1F	Metallothionein 1F	0.5323	67
CLEC18B	C-type lectin domain family 18 member B	0.5269	67
ST13	ST13 Hsp70 interacting protein	0.5265	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	125.9 nTPM
Adipose tissue	137.1 nTPM
Breast	114.6 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	58.0 nTPM
Lung	58.0 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	128.6 nTPM
Liver	217.2 nTPM
Kidney	171.4 nTPM
PBMC	152.7 nTPM
Colon	135.8 nTPM
Stomach	120.8 nTPM
Spleen	118.7 nTPM
Adipose tissue	113.8 nTPM
Lymph node	96.7 nTPM
Breast	92.2 nTPM
Bone marrow	67.0 nTPM

Dendritic cells	150.1 nTPM
Adipose tissue	170.6 nTPM
PBMC	159.4 nTPM
Breast	120.3 nTPM

Endothelial cells	124.6 nTPM
Pancreas	227.8 nTPM
Prostate	187.6 nTPM
Placenta	179.1 nTPM
Testis	142.8 nTPM
Liver	135.8 nTPM
Skeletal muscle	129.8 nTPM
Breast	117.1 nTPM
Endometrium	109.2 nTPM
Skin	108.6 nTPM
Ovary	96.5 nTPM
Lung	90.5 nTPM
Eye	82.5 nTPM
Esophagus	80.9 nTPM
Heart muscle	56.8 nTPM

Enteroendocrine cells	93.3 nTPM
Colon	106.6 nTPM
Rectum	80.1 nTPM

Erythroid cells	131.7 nTPM
Liver	171.0 nTPM
Bone marrow	92.5 nTPM

Fibroblasts	120.8 nTPM
Placenta	224.9 nTPM
Adipose tissue	168.3 nTPM
Prostate	138.5 nTPM
Breast	120.6 nTPM
Ovary	112.0 nTPM
Lung	110.6 nTPM
Skeletal muscle	108.2 nTPM
Skin	101.2 nTPM
Stomach	87.6 nTPM
Heart muscle	79.8 nTPM
Esophagus	77.0 nTPM

Intestinal goblet cells	133.3 nTPM
Colon	201.5 nTPM
Rectum	100.1 nTPM
Small intestine	98.2 nTPM

Macrophages	120.5 nTPM
Kidney	232.9 nTPM
Pancreas	194.0 nTPM
Testis	169.7 nTPM
Prostate	145.6 nTPM
Adipose tissue	143.5 nTPM
Endometrium	136.4 nTPM
Bone marrow	126.2 nTPM
Lung	118.1 nTPM
Breast	107.1 nTPM
Ovary	102.6 nTPM
Stomach	88.0 nTPM
Spleen	85.0 nTPM
Skeletal muscle	80.7 nTPM
Esophagus	64.5 nTPM
PBMC	13.6 nTPM

Paneth cells	102.7 nTPM
Small intestine	105.1 nTPM
Rectum	104.2 nTPM
Colon	98.9 nTPM

Plasma cells	91.2 nTPM
Spleen	133.9 nTPM
Stomach	119.9 nTPM
Bone marrow	82.4 nTPM
Esophagus	61.7 nTPM
Adipose tissue	58.0 nTPM

Respiratory ciliated cells	107.2 nTPM
Bronchus	137.2 nTPM
Lung	77.3 nTPM

Basal keratinocytes	89.1 nTPM
Skin	89.1 nTPM

Basal prostatic cells	186.9 nTPM
Prostate	186.9 nTPM

Basal respiratory cells	238.2 nTPM
Bronchus	238.2 nTPM

Basal squamous epithelial cells	60.3 nTPM
Esophagus	60.3 nTPM

Smooth muscle cells	147.5 nTPM
Bronchus	315.4 nTPM
Pancreas	280.7 nTPM
Skeletal muscle	141.6 nTPM
Adipose tissue	133.6 nTPM
Ovary	130.9 nTPM
Prostate	130.3 nTPM
Skin	112.3 nTPM
Endometrium	109.6 nTPM
Breast	108.4 nTPM
Heart muscle	94.3 nTPM
Esophagus	65.2 nTPM

T-cells	150.1 nTPM
Skin	272.1 nTPM
Kidney	212.1 nTPM
Liver	197.4 nTPM
Adipose tissue	192.7 nTPM
Colon	171.0 nTPM
PBMC	162.9 nTPM
Prostate	151.5 nTPM
Stomach	149.9 nTPM
Lung	147.3 nTPM
Endometrium	140.0 nTPM
Breast	137.7 nTPM
Ovary	120.1 nTPM
Spleen	118.4 nTPM
Skeletal muscle	106.7 nTPM
Lymph node	103.6 nTPM
Bone marrow	103.3 nTPM
Esophagus	65.5 nTPM

Undifferentiated cells	127.7 nTPM
Colon	163.2 nTPM
Small intestine	126.4 nTPM
Rectum	93.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC