Single cell type - SNAPC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNAPC2
Gene descriptionⁱ Full gene name according to HGNC.	Small nuclear RNA activating complex polypeptide 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNAPC2 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAGLN	Transgelin	0.6013	48
TGFB1I1	Transforming growth factor beta 1 induced transcript 1	0.5874	48
CLEC11A	C-type lectin domain containing 11A	0.5650	48
FLNA	Filamin A	0.5585	48
FAM89B	Family with sequence similarity 89 member B	0.5420	7
MYL9	Myosin light chain 9	0.5368	48
ACTA2	Actin alpha 2, smooth muscle	0.5354	48
LCE2A	Late cornified envelope 2A	0.5306	33
FOXL1	Forkhead box L1	0.5282	48
ELOVL3	ELOVL fatty acid elongase 3	0.5185	7
TNN	Tenascin N	0.5168	48
DRAP1	DR1 associated protein 1	0.5147	28
DCTD	DCMP deaminase	0.5025	16
RAB13	RAB13, member RAS oncogene family	0.5004	14
MRGPRF	MAS related GPR family member F	0.4998	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.8 nTPM
Breast	25.9 nTPM
Adipose tissue	13.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	3.7 nTPM
Lung	3.7 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	15.4 nTPM
PBMC	27.1 nTPM
Breast	20.0 nTPM
Lymph node	17.6 nTPM
Liver	16.5 nTPM
Bone marrow	15.5 nTPM
Colon	14.4 nTPM
Spleen	13.9 nTPM
Adipose tissue	10.5 nTPM
Kidney	9.5 nTPM
Stomach	8.6 nTPM

Dendritic cells	22.9 nTPM
PBMC	31.8 nTPM
Breast	22.6 nTPM
Adipose tissue	14.2 nTPM

Endothelial cells	20.7 nTPM
Pancreas	46.4 nTPM
Esophagus	29.9 nTPM
Placenta	27.8 nTPM
Prostate	27.1 nTPM
Skin	27.0 nTPM
Ovary	26.4 nTPM
Breast	22.9 nTPM
Testis	19.8 nTPM
Liver	19.2 nTPM
Endometrium	15.7 nTPM
Skeletal muscle	11.6 nTPM
Eye	6.5 nTPM
Lung	6.2 nTPM
Heart muscle	3.0 nTPM

Fibroblasts	18.5 nTPM
Skin	30.5 nTPM
Placenta	29.9 nTPM
Ovary	24.2 nTPM
Breast	22.0 nTPM
Adipose tissue	21.7 nTPM
Stomach	16.3 nTPM
Skeletal muscle	16.2 nTPM
Esophagus	14.9 nTPM
Prostate	14.6 nTPM
Lung	7.8 nTPM
Heart muscle	5.0 nTPM

Intestinal goblet cells	11.9 nTPM
Colon	13.6 nTPM
Rectum	12.2 nTPM
Small intestine	10.0 nTPM

Macrophages	19.2 nTPM
Pancreas	38.3 nTPM
Testis	30.3 nTPM
Prostate	26.3 nTPM
Breast	25.1 nTPM
Ovary	24.4 nTPM
Kidney	21.1 nTPM
Adipose tissue	17.3 nTPM
Skeletal muscle	16.1 nTPM
Endometrium	15.7 nTPM
Bone marrow	15.0 nTPM
PBMC	13.6 nTPM
Esophagus	12.6 nTPM
Spleen	12.5 nTPM
Lung	10.8 nTPM
Stomach	8.8 nTPM

Paneth cells	6.6 nTPM
Rectum	12.8 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	8.4 nTPM
Spleen	12.6 nTPM
Stomach	11.2 nTPM
Bone marrow	9.9 nTPM
Adipose tissue	8.4 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	3.0 nTPM
Bronchus	5.9 nTPM
Lung	0.0 nTPM

Smooth muscle cells	30.1 nTPM
Pancreas	60.2 nTPM
Esophagus	49.6 nTPM
Breast	46.8 nTPM
Skin	41.5 nTPM
Ovary	34.6 nTPM
Prostate	34.0 nTPM
Endometrium	23.1 nTPM
Adipose tissue	18.8 nTPM
Skeletal muscle	14.0 nTPM
Heart muscle	7.9 nTPM
Bronchus	0.9 nTPM

T-cells	18.4 nTPM
Skin	39.6 nTPM
Breast	25.6 nTPM
Liver	25.2 nTPM
Colon	23.7 nTPM
Kidney	23.3 nTPM
Lymph node	21.3 nTPM
Endometrium	20.2 nTPM
Prostate	19.0 nTPM
PBMC	16.8 nTPM
Ovary	15.6 nTPM
Bone marrow	13.9 nTPM
Stomach	13.9 nTPM
Esophagus	13.1 nTPM
Spleen	12.2 nTPM
Skeletal muscle	11.6 nTPM
Adipose tissue	11.1 nTPM
Lung	7.6 nTPM

Basal keratinocytes	24.3 nTPM
Skin	24.3 nTPM

Basal squamous epithelial cells	35.9 nTPM
Esophagus	35.9 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Undifferentiated cells	15.5 nTPM
Colon	18.0 nTPM
Rectum	14.7 nTPM
Small intestine	13.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC