Cell line - PLEKHA4 - The Human Protein Atlas

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PLEKHA4

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLEKHA4
Gene descriptionⁱ Full gene name according to HGNC.	Pleckstrin homology domain containing A4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SK-MEL-30 - Melanocyte processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AN3-CA, BJ hTERT+ SV40 Large T+ RasG12V, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLEKHA4 is part of cluster 33 SK-MEL-30 - Melanocyte processes with confidenceⁱ 1
391 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SHC4	SHC adaptor protein 4	0.7405	33
SPRY2	Sprouty RTK signaling antagonist 2	0.7336	23
ZFYVE16	Zinc finger FYVE-type containing 16	0.7308	33
ETV5	ETS variant transcription factor 5	0.7227	33
DAAM2	Dishevelled associated activator of morphogenesis 2	0.7215	33
CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1	0.7196	33
DAZ2	Deleted in azoospermia 2	0.7119	33
PAX3	Paired box 3	0.7073	33
BEST1	Bestrophin 1	0.7073	33
TRIM63	Tripartite motif containing 63	0.7022	33
NR4A3	Nuclear receptor subfamily 4 group A member 3	0.6998	33
WARS1	Tryptophanyl-tRNA synthetase 1	0.6915	33
HTR2B	5-hydroxytryptamine receptor 2B	0.6885	33
ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	0.6824	2
SLC24A5	Solute carrier family 24 member 5	0.6802	33

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.