Single cell type - NMRK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NMRK1
Gene descriptionⁱ Full gene name according to HGNC.	Nicotinamide riboside kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NMRK1 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GIMAP1	GTPase, IMAP family member 1	0.5516	63
GALK2	Galactokinase 2	0.5121	42
CISH	Cytokine inducible SH2 containing protein	0.5118	63
GMPR2	Guanosine monophosphate reductase 2	0.5063	39
TRADD	TNFRSF1A associated via death domain	0.5008	3
CDC26	Cell division cycle 26	0.4950	39
SLFN5	Schlafen family member 5	0.4942	63
HDDC3	HD domain containing 3	0.4826	39
FASTKD3	FAST kinase domains 3	0.4814	39
IMP3	IMP U3 small nucleolar ribonucleoprotein 3	0.4796	28
GIMAP7	GTPase, IMAP family member 7	0.4752	63
CD3G	CD3g molecule	0.4721	63
GIMAP4	GTPase, IMAP family member 4	0.4665	63
MED11	Mediator complex subunit 11	0.4650	39
CNDP2	Carnosine dipeptidase 2	0.4643	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	42.2 nTPM
Breast	52.9 nTPM
Adipose tissue	31.6 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	21.7 nTPM
Lung	21.7 nTPM

Astrocytes	11.8 nTPM
Brain	11.8 nTPM

B-cells	22.6 nTPM
Liver	49.8 nTPM
Breast	44.1 nTPM
Kidney	19.0 nTPM
Lymph node	18.2 nTPM
Stomach	18.2 nTPM
Colon	17.6 nTPM
Bone marrow	17.2 nTPM
Spleen	16.6 nTPM
PBMC	15.7 nTPM
Adipose tissue	9.6 nTPM

Dendritic cells	43.7 nTPM
Breast	56.5 nTPM
PBMC	39.8 nTPM
Adipose tissue	34.7 nTPM

Endothelial cells	33.4 nTPM
Testis	65.8 nTPM
Esophagus	56.8 nTPM
Liver	53.2 nTPM
Breast	51.5 nTPM
Skin	38.1 nTPM
Skeletal muscle	35.0 nTPM
Placenta	30.1 nTPM
Ovary	27.7 nTPM
Heart muscle	22.2 nTPM
Prostate	22.1 nTPM
Pancreas	19.3 nTPM
Endometrium	18.4 nTPM
Lung	15.6 nTPM
Eye	11.3 nTPM

Fibroblasts	22.7 nTPM
Heart muscle	45.9 nTPM
Stomach	37.1 nTPM
Esophagus	35.1 nTPM
Breast	27.3 nTPM
Placenta	23.7 nTPM
Lung	19.0 nTPM
Skin	16.3 nTPM
Skeletal muscle	15.1 nTPM
Prostate	12.9 nTPM
Adipose tissue	8.9 nTPM
Ovary	8.7 nTPM

Intestinal goblet cells	34.8 nTPM
Small intestine	40.0 nTPM
Colon	33.6 nTPM
Rectum	30.9 nTPM

Macrophages	22.9 nTPM
Ovary	80.3 nTPM
Breast	41.4 nTPM
Endometrium	25.3 nTPM
Spleen	23.9 nTPM
Esophagus	23.6 nTPM
Prostate	19.5 nTPM
Testis	18.0 nTPM
Bone marrow	17.5 nTPM
Skeletal muscle	15.6 nTPM
Stomach	14.7 nTPM
Adipose tissue	13.8 nTPM
PBMC	13.6 nTPM
Kidney	12.9 nTPM
Lung	12.6 nTPM
Pancreas	10.2 nTPM

Paneth cells	26.1 nTPM
Colon	29.6 nTPM
Small intestine	26.3 nTPM
Rectum	22.4 nTPM

Plasma cells	68.8 nTPM
Esophagus	92.4 nTPM
Stomach	84.5 nTPM
Spleen	69.2 nTPM
Bone marrow	61.0 nTPM
Adipose tissue	36.7 nTPM

Respiratory ciliated cells	30.5 nTPM
Bronchus	39.0 nTPM
Lung	21.9 nTPM

Smooth muscle cells	15.0 nTPM
Breast	30.9 nTPM
Pancreas	19.6 nTPM
Heart muscle	16.8 nTPM
Skin	15.0 nTPM
Adipose tissue	14.1 nTPM
Skeletal muscle	13.5 nTPM
Prostate	13.4 nTPM
Endometrium	11.3 nTPM
Bronchus	11.2 nTPM
Ovary	9.6 nTPM
Esophagus	9.3 nTPM

T-cells	48.8 nTPM
Breast	88.2 nTPM
Lymph node	67.1 nTPM
Stomach	66.9 nTPM
PBMC	63.1 nTPM
Kidney	56.9 nTPM
Spleen	52.4 nTPM
Colon	51.3 nTPM
Liver	48.1 nTPM
Adipose tissue	46.8 nTPM
Ovary	44.5 nTPM
Prostate	42.6 nTPM
Bone marrow	42.2 nTPM
Endometrium	39.6 nTPM
Skeletal muscle	35.3 nTPM
Esophagus	32.8 nTPM
Lung	25.8 nTPM
Skin	25.4 nTPM

Basal keratinocytes	21.0 nTPM
Skin	21.0 nTPM

Basal prostatic cells	36.4 nTPM
Prostate	36.4 nTPM

Basal respiratory cells	38.2 nTPM
Bronchus	38.2 nTPM

Basal squamous epithelial cells	38.7 nTPM
Esophagus	38.7 nTPM

Undifferentiated cells	25.0 nTPM
Small intestine	28.3 nTPM
Rectum	26.7 nTPM
Colon	20.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC