Single cell type - PLGRKT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLGRKT
Gene descriptionⁱ Full gene name according to HGNC.	Plasminogen receptor with a C-terminal lysine
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLGRKT is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LGALS3	Galectin 3	0.6813	53
EPCAM	Epithelial cell adhesion molecule	0.6404	53
SMIM22	Small integral membrane protein 22	0.6402	53
TMEM9B	TMEM9 domain family member B	0.6034	26
PRR15L	Proline rich 15 like	0.5940	45
C15orf48	Chromosome 15 open reading frame 48	0.5924	16
STAP2	Signal transducing adaptor family member 2	0.5858	45
LGALS4	Galectin 4	0.5825	53
CDX2	Caudal type homeobox 2	0.5658	53
TSPAN8	Tetraspanin 8	0.5618	45
SNX15	Sorting nexin 15	0.5607	53
TLDC2	TBC/LysM-associated domain containing 2	0.5588	45
TMEM171	Transmembrane protein 171	0.5548	53
B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	0.5365	45
FXYD3	FXYD domain containing ion transport regulator 3	0.5313	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.8 nTPM
Breast	33.4 nTPM
Adipose tissue	22.2 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	25.5 nTPM
Lung	25.5 nTPM

Astrocytes	25.5 nTPM
Brain	25.5 nTPM

B-cells	22.0 nTPM
Liver	31.1 nTPM
Bone marrow	27.0 nTPM
Breast	25.5 nTPM
Spleen	23.9 nTPM
Kidney	23.8 nTPM
Lymph node	22.4 nTPM
Stomach	18.2 nTPM
Colon	17.6 nTPM
Adipose tissue	17.6 nTPM
PBMC	12.9 nTPM

Dendritic cells	23.1 nTPM
Breast	44.8 nTPM
Adipose tissue	16.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	21.2 nTPM
Placenta	46.0 nTPM
Breast	28.4 nTPM
Prostate	26.2 nTPM
Skin	23.9 nTPM
Endometrium	22.9 nTPM
Esophagus	19.5 nTPM
Pancreas	19.3 nTPM
Heart muscle	18.8 nTPM
Liver	17.4 nTPM
Skeletal muscle	16.7 nTPM
Lung	15.6 nTPM
Eye	15.4 nTPM
Testis	14.9 nTPM
Ovary	11.7 nTPM

Fibroblasts	25.3 nTPM
Heart muscle	45.2 nTPM
Placenta	34.1 nTPM
Breast	33.9 nTPM
Adipose tissue	33.7 nTPM
Skin	28.3 nTPM
Ovary	24.1 nTPM
Skeletal muscle	21.2 nTPM
Esophagus	19.4 nTPM
Prostate	16.5 nTPM
Lung	14.5 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	124.2 nTPM
Rectum	138.4 nTPM
Colon	127.2 nTPM
Small intestine	107.0 nTPM

Macrophages	33.0 nTPM
Pancreas	109.7 nTPM
Prostate	42.3 nTPM
Breast	42.3 nTPM
Lung	39.5 nTPM
Kidney	34.8 nTPM
Ovary	33.8 nTPM
Endometrium	32.4 nTPM
Testis	32.0 nTPM
Spleen	27.0 nTPM
Adipose tissue	24.2 nTPM
Skeletal muscle	22.1 nTPM
Bone marrow	21.2 nTPM
Esophagus	18.9 nTPM
Stomach	14.7 nTPM
PBMC	0.0 nTPM

Paneth cells	157.2 nTPM
Colon	194.4 nTPM
Rectum	149.7 nTPM
Small intestine	127.6 nTPM

Plasma cells	23.0 nTPM
Spleen	31.8 nTPM
Esophagus	30.7 nTPM
Bone marrow	26.4 nTPM
Stomach	16.5 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	52.6 nTPM
Bronchus	54.1 nTPM
Lung	51.0 nTPM

Smooth muscle cells	33.2 nTPM
Pancreas	140.5 nTPM
Bronchus	39.3 nTPM
Endometrium	26.0 nTPM
Breast	25.0 nTPM
Ovary	24.5 nTPM
Heart muscle	23.0 nTPM
Skeletal muscle	21.0 nTPM
Skin	20.2 nTPM
Adipose tissue	19.0 nTPM
Prostate	16.2 nTPM
Esophagus	10.9 nTPM

T-cells	33.0 nTPM
Kidney	59.6 nTPM
Ovary	55.6 nTPM
Prostate	42.6 nTPM
Breast	39.0 nTPM
Lung	38.0 nTPM
Skin	34.0 nTPM
Lymph node	33.0 nTPM
Spleen	32.9 nTPM
Bone marrow	32.5 nTPM
Liver	32.0 nTPM
Colon	30.9 nTPM
Stomach	29.6 nTPM
Skeletal muscle	26.2 nTPM
Endometrium	24.3 nTPM
Adipose tissue	20.2 nTPM
PBMC	17.4 nTPM
Esophagus	13.1 nTPM

Basal prostatic cells	23.4 nTPM
Prostate	23.4 nTPM

Basal respiratory cells	144.2 nTPM
Bronchus	144.2 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Cytotrophoblasts	88.6 nTPM
Placenta	88.6 nTPM

Undifferentiated cells	106.1 nTPM
Small intestine	120.7 nTPM
Rectum	109.1 nTPM
Colon	88.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC