Single cell type - GTPBP4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GTPBP4
Gene descriptionⁱ Full gene name according to HGNC.	GTP binding protein 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GTPBP4 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GNL2	G protein nucleolar 2	0.6752	10
MAK16	MAK16 homolog	0.6202	10
IFNK	Interferon kappa	0.6121	44
DNTTIP2	Deoxynucleotidyltransferase terminal interacting protein 2	0.6108	10
SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein	0.6058	10
PRPF40A	Pre-mRNA processing factor 40 homolog A	0.6047	10
ANKLE2	Ankyrin repeat and LEM domain containing 2	0.5954	44
SEH1L	SEH1 like nucleoporin	0.5889	39
WDR43	WD repeat domain 43	0.5797	44
BX276092.9	Chromosome X open reading frame 49-like	0.5768	44
AC107871.1	Novel protein	0.5754	11
KRTAP4-9	Keratin associated protein 4-9	0.5722	44
AL358113.1	Novel protein	0.5683	44
PNN	Pinin, desmosome associated protein	0.5653	52
ILF3	Interleukin enhancer binding factor 3	0.5621	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.2 nTPM
Adipose tissue	41.0 nTPM
Breast	31.5 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	74.3 nTPM
Lung	74.3 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	41.8 nTPM
Stomach	66.3 nTPM
Spleen	53.3 nTPM
Liver	50.0 nTPM
Adipose tissue	42.2 nTPM
Bone marrow	38.5 nTPM
Colon	36.7 nTPM
Kidney	33.4 nTPM
PBMC	32.9 nTPM
Lymph node	32.4 nTPM
Breast	32.1 nTPM

Dendritic cells	37.4 nTPM
Adipose tissue	44.5 nTPM
Breast	35.7 nTPM
PBMC	31.8 nTPM

Endothelial cells	49.2 nTPM
Lung	177.8 nTPM
Pancreas	84.9 nTPM
Prostate	67.9 nTPM
Endometrium	43.1 nTPM
Skeletal muscle	42.1 nTPM
Placenta	40.9 nTPM
Ovary	40.8 nTPM
Eye	33.2 nTPM
Testis	31.2 nTPM
Liver	29.3 nTPM
Esophagus	27.3 nTPM
Skin	27.2 nTPM
Breast	25.3 nTPM
Heart muscle	18.0 nTPM

Fibroblasts	48.9 nTPM
Lung	184.3 nTPM
Prostate	77.0 nTPM
Ovary	50.7 nTPM
Skeletal muscle	43.1 nTPM
Stomach	37.1 nTPM
Placenta	36.0 nTPM
Adipose tissue	32.8 nTPM
Skin	26.8 nTPM
Breast	23.6 nTPM
Esophagus	13.9 nTPM
Heart muscle	12.2 nTPM

Intestinal goblet cells	29.9 nTPM
Colon	43.6 nTPM
Rectum	26.3 nTPM
Small intestine	20.0 nTPM

Macrophages	33.1 nTPM
Lung	88.2 nTPM
Endometrium	53.3 nTPM
Adipose tissue	45.0 nTPM
Testis	34.3 nTPM
Prostate	32.0 nTPM
Kidney	31.8 nTPM
Breast	30.6 nTPM
Skeletal muscle	29.4 nTPM
Stomach	29.4 nTPM
Spleen	26.0 nTPM
Pancreas	25.5 nTPM
Esophagus	25.2 nTPM
Bone marrow	23.7 nTPM
Ovary	22.1 nTPM
PBMC	0.0 nTPM

Paneth cells	17.3 nTPM
Rectum	23.2 nTPM
Small intestine	18.8 nTPM
Colon	9.9 nTPM

Plasma cells	37.0 nTPM
Spleen	46.4 nTPM
Stomach	43.3 nTPM
Adipose tissue	38.8 nTPM
Bone marrow	37.9 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	55.8 nTPM
Lung	72.9 nTPM
Bronchus	38.8 nTPM

Smooth muscle cells	51.4 nTPM
Bronchus	115.4 nTPM
Pancreas	110.1 nTPM
Ovary	59.0 nTPM
Prostate	52.5 nTPM
Skeletal muscle	45.2 nTPM
Endometrium	41.9 nTPM
Esophagus	34.1 nTPM
Heart muscle	28.3 nTPM
Breast	26.7 nTPM
Adipose tissue	26.3 nTPM
Skin	25.5 nTPM

T-cells	37.5 nTPM
Lung	95.7 nTPM
Endometrium	49.3 nTPM
Adipose tissue	47.7 nTPM
Colon	46.6 nTPM
Stomach	44.4 nTPM
PBMC	43.8 nTPM
Bone marrow	37.6 nTPM
Ovary	33.3 nTPM
Breast	32.8 nTPM
Spleen	29.4 nTPM
Liver	29.2 nTPM
Kidney	28.7 nTPM
Lymph node	28.6 nTPM
Skeletal muscle	28.1 nTPM
Skin	25.7 nTPM
Prostate	23.6 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	62.7 nTPM
Skin	62.7 nTPM

Basal prostatic cells	100.0 nTPM
Prostate	100.0 nTPM

Basal respiratory cells	52.8 nTPM
Bronchus	52.8 nTPM

Basal squamous epithelial cells	35.3 nTPM
Esophagus	35.3 nTPM

Undifferentiated cells	32.6 nTPM
Colon	42.4 nTPM
Small intestine	28.7 nTPM
Rectum	26.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC