Single cell type - DNTTIP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNTTIP2
Gene descriptionⁱ Full gene name according to HGNC.	Deoxynucleotidyltransferase terminal interacting protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DNTTIP2 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.98
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MPHOSPH10	M-phase phosphoprotein 10	0.6191	10
GTPBP4	GTP binding protein 4	0.6108	44
PPIL4	Peptidylprolyl isomerase like 4	0.5927	22
PITPNB	Phosphatidylinositol transfer protein beta	0.5699	22
GNL2	G protein nucleolar 2	0.5666	10
SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein	0.5580	10
DDX5	DEAD-box helicase 5	0.5507	52
TRMT6	TRNA methyltransferase 6	0.5420	10
AKAP8	A-kinase anchoring protein 8	0.5391	44
SNW1	SNW domain containing 1	0.5333	10
FERMT2	Fermitin family member 2	0.5291	48
CCDC47	Coiled-coil domain containing 47	0.5268	10
MAK16	MAK16 homolog	0.5205	10
HNRNPH3	Heterogeneous nuclear ribonucleoprotein H3	0.5203	22
IL6	Interleukin 6	0.5155	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	98.9 nTPM
Adipose tissue	123.3 nTPM
Breast	74.4 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	78.2 nTPM
Lung	78.2 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	66.7 nTPM
Adipose tissue	120.8 nTPM
Breast	88.2 nTPM
Stomach	88.1 nTPM
Colon	78.3 nTPM
Spleen	69.6 nTPM
Lymph node	56.6 nTPM
PBMC	49.9 nTPM
Kidney	47.6 nTPM
Liver	41.2 nTPM
Bone marrow	27.0 nTPM

Dendritic cells	110.2 nTPM
Adipose tissue	173.8 nTPM
Breast	113.0 nTPM
PBMC	43.8 nTPM

Endothelial cells	74.2 nTPM
Prostate	158.2 nTPM
Skeletal muscle	141.2 nTPM
Lung	127.9 nTPM
Pancreas	104.2 nTPM
Heart muscle	94.4 nTPM
Endometrium	79.5 nTPM
Skin	65.2 nTPM
Eye	49.3 nTPM
Ovary	48.1 nTPM
Breast	41.6 nTPM
Placenta	39.3 nTPM
Esophagus	38.3 nTPM
Testis	37.3 nTPM
Liver	14.7 nTPM

Fibroblasts	54.3 nTPM
Lung	127.3 nTPM
Prostate	108.7 nTPM
Heart muscle	76.8 nTPM
Skeletal muscle	55.7 nTPM
Stomach	43.0 nTPM
Ovary	38.7 nTPM
Adipose tissue	36.1 nTPM
Breast	30.4 nTPM
Placenta	30.3 nTPM
Skin	30.1 nTPM
Esophagus	20.4 nTPM

Intestinal goblet cells	14.5 nTPM
Colon	19.3 nTPM
Rectum	16.2 nTPM
Small intestine	8.1 nTPM

Macrophages	75.8 nTPM
Adipose tissue	186.9 nTPM
Skeletal muscle	181.3 nTPM
Lung	127.2 nTPM
Endometrium	122.3 nTPM
Breast	100.3 nTPM
Pancreas	68.9 nTPM
Prostate	60.8 nTPM
Spleen	57.0 nTPM
Stomach	43.9 nTPM
Ovary	41.7 nTPM
Esophagus	39.3 nTPM
Testis	36.0 nTPM
Bone marrow	30.0 nTPM
Kidney	27.2 nTPM
PBMC	13.6 nTPM

Paneth cells	20.1 nTPM
Small intestine	30.0 nTPM
Rectum	17.0 nTPM
Colon	13.2 nTPM

Plasma cells	50.1 nTPM
Adipose tissue	113.5 nTPM
Stomach	44.3 nTPM
Spleen	39.7 nTPM
Bone marrow	34.6 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	85.1 nTPM
Lung	128.2 nTPM
Bronchus	41.9 nTPM

Smooth muscle cells	79.0 nTPM
Bronchus	127.8 nTPM
Prostate	125.7 nTPM
Heart muscle	116.8 nTPM
Skin	106.1 nTPM
Skeletal muscle	91.4 nTPM
Ovary	58.0 nTPM
Pancreas	57.7 nTPM
Endometrium	56.0 nTPM
Breast	51.9 nTPM
Adipose tissue	48.0 nTPM
Esophagus	29.4 nTPM

T-cells	87.7 nTPM
Adipose tissue	169.6 nTPM
Lung	153.4 nTPM
Endometrium	131.7 nTPM
Breast	118.8 nTPM
Ovary	117.9 nTPM
Skin	98.1 nTPM
Skeletal muscle	92.8 nTPM
Colon	90.3 nTPM
Prostate	80.4 nTPM
Stomach	71.3 nTPM
Spleen	69.0 nTPM
Lymph node	66.6 nTPM
PBMC	51.0 nTPM
Kidney	50.0 nTPM
Bone marrow	46.1 nTPM
Liver	43.9 nTPM
Esophagus	39.3 nTPM

Basal keratinocytes	54.4 nTPM
Skin	54.4 nTPM

Basal prostatic cells	163.0 nTPM
Prostate	163.0 nTPM

Basal respiratory cells	57.9 nTPM
Bronchus	57.9 nTPM

Basal squamous epithelial cells	43.3 nTPM
Esophagus	43.3 nTPM

Undifferentiated cells	23.1 nTPM
Colon	33.9 nTPM
Small intestine	20.5 nTPM
Rectum	15.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC