Single cell type - C1QBP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C1QBP
Gene descriptionⁱ Full gene name according to HGNC.	Complement C1q binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

C1QBP is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
STOML2	Stomatin like 2	0.6568	39
APEX1	Apurinic/apyrimidinic endodeoxyribonuclease 1	0.6325	32
SNRPF	Small nuclear ribonucleoprotein polypeptide F	0.6171	32
NHP2	NHP2 ribonucleoprotein	0.6046	39
ATAD3A	ATPase family AAA domain containing 3A	0.6034	39
CYC1	Cytochrome c1	0.5987	39
EXOSC5	Exosome component 5	0.5949	38
TOMM40	Translocase of outer mitochondrial membrane 40	0.5945	39
NME1	NME/NM23 nucleoside diphosphate kinase 1	0.5937	10
NAA10	N-alpha-acetyltransferase 10, NatA catalytic subunit	0.5888	39
NLE1	Notchless homolog 1	0.5885	39
TRAP1	TNF receptor associated protein 1	0.5845	67
PHB	Prohibitin	0.5739	10
MRPL11	Mitochondrial ribosomal protein L11	0.5724	39
MRTO4	MRT4 homolog, ribosome maturation factor	0.5709	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	101.6 nTPM
Breast	135.7 nTPM
Adipose tissue	67.5 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	30.5 nTPM
Lung	30.5 nTPM

Astrocytes	10.7 nTPM
Brain	10.7 nTPM

B-cells	153.1 nTPM
Liver	333.6 nTPM
PBMC	177.1 nTPM
Spleen	171.7 nTPM
Kidney	161.9 nTPM
Colon	134.2 nTPM
Bone marrow	129.1 nTPM
Breast	109.7 nTPM
Adipose tissue	107.3 nTPM
Stomach	106.3 nTPM
Lymph node	99.9 nTPM

Basal squamous epithelial cells	165.0 nTPM
Esophagus	165.0 nTPM

Dendritic cells	115.0 nTPM
PBMC	135.5 nTPM
Breast	126.5 nTPM
Adipose tissue	83.1 nTPM

Endothelial cells	108.2 nTPM
Pancreas	204.6 nTPM
Prostate	175.2 nTPM
Skin	140.9 nTPM
Ovary	137.7 nTPM
Placenta	130.1 nTPM
Endometrium	115.0 nTPM
Testis	114.9 nTPM
Breast	109.9 nTPM
Liver	92.7 nTPM
Esophagus	79.8 nTPM
Skeletal muscle	78.0 nTPM
Eye	77.7 nTPM
Heart muscle	33.0 nTPM
Lung	24.9 nTPM

Erythroid cells	183.1 nTPM
Bone marrow	269.9 nTPM
Liver	96.4 nTPM

Fibroblasts	101.0 nTPM
Ovary	215.0 nTPM
Prostate	143.7 nTPM
Placenta	131.1 nTPM
Skin	110.3 nTPM
Breast	96.9 nTPM
Adipose tissue	95.3 nTPM
Stomach	81.7 nTPM
Skeletal muscle	67.7 nTPM
Esophagus	65.7 nTPM
Lung	53.6 nTPM
Heart muscle	50.1 nTPM

Intestinal goblet cells	190.2 nTPM
Colon	281.5 nTPM
Rectum	173.0 nTPM
Small intestine	116.1 nTPM

Macrophages	101.8 nTPM
Pancreas	229.7 nTPM
Kidney	151.3 nTPM
Testis	134.8 nTPM
Endometrium	134.2 nTPM
Prostate	133.0 nTPM
Breast	129.0 nTPM
Esophagus	105.4 nTPM
Adipose tissue	86.6 nTPM
Ovary	83.9 nTPM
Spleen	82.9 nTPM
Bone marrow	82.5 nTPM
Skeletal muscle	63.8 nTPM
Stomach	49.8 nTPM
Lung	32.0 nTPM
PBMC	27.3 nTPM

Paneth cells	128.5 nTPM
Rectum	246.7 nTPM
Small intestine	82.6 nTPM
Colon	56.0 nTPM

Plasma cells	197.4 nTPM
Spleen	356.9 nTPM
Bone marrow	354.3 nTPM
Stomach	123.4 nTPM
Esophagus	117.0 nTPM
Adipose tissue	35.5 nTPM

Respiratory ciliated cells	65.1 nTPM
Bronchus	112.6 nTPM
Lung	17.5 nTPM

Cholangiocytes	102.9 nTPM
Liver	102.9 nTPM

Collecting duct cells	82.8 nTPM
Kidney	82.8 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Cytotrophoblasts	323.8 nTPM
Placenta	323.8 nTPM

Smooth muscle cells	189.1 nTPM
Bronchus	662.2 nTPM
Pancreas	358.4 nTPM
Ovary	191.4 nTPM
Prostate	157.2 nTPM
Breast	129.3 nTPM
Skin	123.8 nTPM
Skeletal muscle	106.5 nTPM
Endometrium	100.4 nTPM
Heart muscle	91.0 nTPM
Esophagus	82.2 nTPM
Adipose tissue	77.0 nTPM

T-cells	105.5 nTPM
PBMC	218.8 nTPM
Kidney	155.4 nTPM
Ovary	131.3 nTPM
Skin	130.3 nTPM
Lymph node	123.1 nTPM
Liver	119.8 nTPM
Bone marrow	116.2 nTPM
Stomach	111.0 nTPM
Spleen	110.2 nTPM
Breast	102.9 nTPM
Colon	93.2 nTPM
Endometrium	84.3 nTPM
Adipose tissue	83.2 nTPM
Skeletal muscle	78.7 nTPM
Esophagus	78.6 nTPM
Prostate	47.3 nTPM
Lung	9.1 nTPM

Undifferentiated cells	364.0 nTPM
Colon	468.8 nTPM
Small intestine	329.1 nTPM
Rectum	294.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC