Single cell type - WSB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WSB1
Gene descriptionⁱ Full gene name according to HGNC.	WD repeat and SOCS box containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

WSB1 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NFKBIZ	NFKB inhibitor zeta	0.4512	41
RASGEF1B	RasGEF domain family member 1B	0.4484	41
C9orf72	C9orf72-SMCR8 complex subunit	0.4363	41
AFF4	AF4/FMR2 family member 4	0.4346	44
CH25H	Cholesterol 25-hydroxylase	0.4338	41
KDM6B	Lysine demethylase 6B	0.4324	41
ZKSCAN2	Zinc finger with KRAB and SCAN domains 2	0.4319	40
IPMK	Inositol polyphosphate multikinase	0.4246	41
TET2	Tet methylcytosine dioxygenase 2	0.4160	41
ZMAT1	Zinc finger matrin-type 1	0.4154	52
ABHD5	Abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	0.4149	7
NAMPT	Nicotinamide phosphoribosyltransferase	0.4106	41
IRS2	Insulin receptor substrate 2	0.4082	41
DUSP1	Dual specificity phosphatase 1	0.4080	41
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.4059	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	300.4 nTPM
Adipose tissue	370.6 nTPM
Breast	230.2 nTPM

Alveolar cells type 1	221.2 nTPM
Lung	221.2 nTPM

Alveolar cells type 2	476.1 nTPM
Lung	476.1 nTPM

Astrocytes	189.7 nTPM
Brain	189.7 nTPM

B-cells	245.4 nTPM
Lymph node	464.9 nTPM
Adipose tissue	376.9 nTPM
Stomach	298.3 nTPM
Spleen	281.0 nTPM
Colon	276.3 nTPM
Breast	259.5 nTPM
Kidney	166.7 nTPM
Bone marrow	162.7 nTPM
PBMC	102.8 nTPM
Liver	64.9 nTPM

Basal squamous epithelial cells	253.8 nTPM
Esophagus	253.8 nTPM

Dendritic cells	183.2 nTPM
Adipose tissue	299.8 nTPM
Breast	178.2 nTPM
PBMC	71.8 nTPM

Endothelial cells	254.9 nTPM
Skeletal muscle	451.2 nTPM
Heart muscle	325.0 nTPM
Eye	297.0 nTPM
Placenta	295.5 nTPM
Liver	277.9 nTPM
Endometrium	275.3 nTPM
Lung	262.0 nTPM
Prostate	251.7 nTPM
Esophagus	245.1 nTPM
Breast	244.4 nTPM
Skin	211.7 nTPM
Testis	175.4 nTPM
Ovary	171.8 nTPM
Pancreas	84.9 nTPM

Enteroendocrine cells	194.4 nTPM
Colon	231.0 nTPM
Rectum	157.8 nTPM

Erythroid cells	148.1 nTPM
Liver	171.0 nTPM
Bone marrow	125.2 nTPM

Fibroblasts	284.6 nTPM
Prostate	458.4 nTPM
Placenta	416.8 nTPM
Breast	348.7 nTPM
Adipose tissue	321.1 nTPM
Stomach	319.2 nTPM
Skin	285.1 nTPM
Skeletal muscle	267.5 nTPM
Esophagus	266.1 nTPM
Lung	177.6 nTPM
Heart muscle	169.4 nTPM
Ovary	100.9 nTPM

Intestinal goblet cells	191.5 nTPM
Colon	223.0 nTPM
Small intestine	200.9 nTPM
Rectum	150.7 nTPM

Macrophages	358.9 nTPM
Spleen	764.2 nTPM
Bone marrow	643.5 nTPM
Adipose tissue	577.0 nTPM
Breast	536.6 nTPM
Esophagus	437.5 nTPM
Stomach	392.7 nTPM
Prostate	330.1 nTPM
Kidney	324.4 nTPM
Skeletal muscle	305.9 nTPM
Testis	276.5 nTPM
Endometrium	272.6 nTPM
Lung	248.2 nTPM
Ovary	177.1 nTPM
Pancreas	84.2 nTPM
PBMC	13.6 nTPM

Paneth cells	185.4 nTPM
Colon	220.7 nTPM
Small intestine	176.5 nTPM
Rectum	158.9 nTPM

Plasma cells	144.9 nTPM
Adipose tissue	310.2 nTPM
Stomach	169.1 nTPM
Spleen	93.3 nTPM
Esophagus	92.4 nTPM
Bone marrow	59.4 nTPM

Cholangiocytes	144.4 nTPM
Liver	144.4 nTPM

Collecting duct cells	239.1 nTPM
Kidney	239.1 nTPM

Cone photoreceptor cells	348.2 nTPM
Eye	348.2 nTPM

Cytotrophoblasts	360.7 nTPM
Placenta	360.7 nTPM

Respiratory ciliated cells	137.5 nTPM
Bronchus	156.9 nTPM
Lung	118.1 nTPM

Smooth muscle cells	221.9 nTPM
Adipose tissue	341.6 nTPM
Prostate	327.3 nTPM
Skin	287.8 nTPM
Skeletal muscle	266.8 nTPM
Esophagus	240.3 nTPM
Breast	211.6 nTPM
Endometrium	206.0 nTPM
Heart muscle	197.8 nTPM
Ovary	175.7 nTPM
Bronchus	121.9 nTPM
Pancreas	64.1 nTPM

T-cells	183.9 nTPM
Adipose tissue	291.9 nTPM
Breast	286.8 nTPM
Lymph node	286.0 nTPM
Esophagus	242.3 nTPM
Skin	224.8 nTPM
Endometrium	223.6 nTPM
Skeletal muscle	194.8 nTPM
Prostate	194.1 nTPM
Colon	192.5 nTPM
Spleen	183.3 nTPM
Stomach	157.1 nTPM
Ovary	146.8 nTPM
Liver	120.4 nTPM
Lung	109.4 nTPM
Bone marrow	95.6 nTPM
Kidney	95.1 nTPM
PBMC	81.9 nTPM

Undifferentiated cells	133.6 nTPM
Colon	152.9 nTPM
Small intestine	124.9 nTPM
Rectum	122.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC