Single cell type - TET2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TET2
Gene descriptionⁱ Full gene name according to HGNC.	Tet methylcytosine dioxygenase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TET2 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EREG	Epiregulin	0.7667	41
NLRP3	NLR family pyrin domain containing 3	0.7626	41
CYRIA	CYFIP related Rac1 interactor A	0.7426	41
CSGALNACT2	Chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.7415	41
IL1B	Interleukin 1 beta	0.7368	41
C5AR1	Complement C5a receptor 1	0.7277	41
C9orf72	C9orf72-SMCR8 complex subunit	0.7163	41
RILPL2	Rab interacting lysosomal protein like 2	0.7133	41
PTPRE	Protein tyrosine phosphatase receptor type E	0.7063	41
POLR1F	RNA polymerase I subunit F	0.6999	41
MARCHF1	Membrane associated ring-CH-type finger 1	0.6937	41
C5AR2	Complement component 5a receptor 2	0.6898	41
LIPN	Lipase family member N	0.6876	41
IRAK3	Interleukin 1 receptor associated kinase 3	0.6865	41
RP2	RP2 activator of ARL3 GTPase	0.6791	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.5 nTPM
Breast	25.7 nTPM
Adipose tissue	23.3 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	29.1 nTPM
Lung	29.1 nTPM

Astrocytes	58.8 nTPM
Brain	58.8 nTPM

B-cells	28.3 nTPM
Adipose tissue	87.2 nTPM
Colon	49.5 nTPM
Stomach	29.0 nTPM
Spleen	25.3 nTPM
Breast	24.1 nTPM
Lymph node	21.9 nTPM
PBMC	21.4 nTPM
Bone marrow	9.8 nTPM
Liver	9.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	34.1 nTPM
Adipose tissue	61.6 nTPM
Breast	20.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	20.3 nTPM
Heart muscle	42.4 nTPM
Endometrium	31.4 nTPM
Eye	29.9 nTPM
Skeletal muscle	29.0 nTPM
Ovary	23.5 nTPM
Esophagus	21.2 nTPM
Lung	18.7 nTPM
Breast	18.3 nTPM
Pancreas	15.5 nTPM
Prostate	14.0 nTPM
Skin	13.2 nTPM
Liver	11.9 nTPM
Placenta	8.0 nTPM
Testis	6.8 nTPM

Fibroblasts	18.0 nTPM
Heart muscle	38.9 nTPM
Lung	25.7 nTPM
Stomach	25.3 nTPM
Esophagus	23.7 nTPM
Skeletal muscle	15.7 nTPM
Breast	14.2 nTPM
Ovary	13.3 nTPM
Adipose tissue	13.0 nTPM
Prostate	12.9 nTPM
Skin	7.7 nTPM
Placenta	7.2 nTPM

Intestinal goblet cells	15.8 nTPM
Rectum	17.6 nTPM
Colon	15.0 nTPM
Small intestine	14.8 nTPM

Macrophages	98.3 nTPM
Adipose tissue	324.8 nTPM
Skeletal muscle	229.5 nTPM
Stomach	149.5 nTPM
Spleen	146.2 nTPM
Endometrium	108.3 nTPM
Esophagus	97.6 nTPM
Breast	67.5 nTPM
Lung	59.2 nTPM
Bone marrow	56.3 nTPM
Kidney	56.0 nTPM
Testis	54.0 nTPM
Ovary	47.6 nTPM
Prostate	40.1 nTPM
PBMC	27.3 nTPM
Pancreas	10.2 nTPM

Paneth cells	18.7 nTPM
Small intestine	22.5 nTPM
Colon	19.7 nTPM
Rectum	13.8 nTPM

Plasma cells	22.5 nTPM
Adipose tissue	80.1 nTPM
Spleen	13.6 nTPM
Bone marrow	9.9 nTPM
Stomach	8.8 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	22.3 nTPM
Lung	23.3 nTPM
Bronchus	21.3 nTPM

Smooth muscle cells	21.7 nTPM
Heart muscle	67.5 nTPM
Endometrium	39.1 nTPM
Esophagus	21.7 nTPM
Adipose tissue	21.1 nTPM
Skeletal muscle	17.1 nTPM
Prostate	16.6 nTPM
Breast	16.1 nTPM
Ovary	14.4 nTPM
Bronchus	10.2 nTPM
Skin	8.0 nTPM
Pancreas	6.5 nTPM

T-cells	18.9 nTPM
Adipose tissue	40.9 nTPM
Endometrium	36.5 nTPM
Skeletal muscle	31.9 nTPM
Lung	25.8 nTPM
Colon	25.6 nTPM
Prostate	19.0 nTPM
Stomach	18.2 nTPM
Liver	16.7 nTPM
Breast	16.7 nTPM
Spleen	15.5 nTPM
Lymph node	14.6 nTPM
Bone marrow	14.0 nTPM
Esophagus	13.1 nTPM
PBMC	11.2 nTPM
Ovary	8.9 nTPM
Skin	6.9 nTPM
Kidney	6.2 nTPM

Basal prostatic cells	11.0 nTPM
Prostate	11.0 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	14.0 nTPM
Rectum	14.5 nTPM
Colon	13.9 nTPM
Small intestine	13.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC