Single cell type - OSBP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSBP
Gene descriptionⁱ Full gene name according to HGNC.	Oxysterol binding protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OSBP is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.59
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARCN1	Archain 1	0.5827	55
YY1	YY1 transcription factor	0.5434	10
TXLNA	Taxilin alpha	0.5410	36
GTF3C4	General transcription factor IIIC subunit 4	0.5236	10
FBRSL1	Fibrosin like 1	0.5206	65
TM9SF3	Transmembrane 9 superfamily member 3	0.5179	27
ALYREF	Aly/REF export factor	0.5009	7
DHX8	DEAH-box helicase 8	0.4974	52
SPTY2D1	SPT2 chromatin protein domain containing 1	0.4971	24
USP38	Ubiquitin specific peptidase 38	0.4864	44
CTBP1	C-terminal binding protein 1	0.4774	65
TENT4A	Terminal nucleotidyltransferase 4A	0.4755	65
SEC16A	SEC16 homolog A, endoplasmic reticulum export factor	0.4695	27
ZNF654	Zinc finger protein 654	0.4651	44
RBM12	RNA binding motif protein 12	0.4611	65

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.2 nTPM
Adipose tissue	32.9 nTPM
Breast	25.6 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	9.0 nTPM
Lung	9.0 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	18.9 nTPM
Adipose tissue	39.0 nTPM
Lymph node	24.6 nTPM
Bone marrow	21.3 nTPM
Liver	19.7 nTPM
Colon	19.2 nTPM
Spleen	18.7 nTPM
Breast	17.3 nTPM
Stomach	14.5 nTPM
PBMC	9.9 nTPM
Kidney	4.8 nTPM

Dendritic cells	31.1 nTPM
Adipose tissue	44.2 nTPM
PBMC	27.9 nTPM
Breast	21.1 nTPM

Endothelial cells	21.8 nTPM
Prostate	33.1 nTPM
Endometrium	33.1 nTPM
Skeletal muscle	27.1 nTPM
Ovary	25.6 nTPM
Pancreas	23.1 nTPM
Breast	22.8 nTPM
Liver	22.0 nTPM
Skin	22.0 nTPM
Esophagus	19.0 nTPM
Lung	18.7 nTPM
Eye	17.8 nTPM
Heart muscle	15.2 nTPM
Testis	13.9 nTPM
Placenta	11.3 nTPM

Fibroblasts	21.1 nTPM
Prostate	32.5 nTPM
Skeletal muscle	26.5 nTPM
Adipose tissue	23.6 nTPM
Skin	22.5 nTPM
Ovary	20.7 nTPM
Breast	20.5 nTPM
Esophagus	20.4 nTPM
Heart muscle	18.2 nTPM
Lung	17.9 nTPM
Stomach	17.8 nTPM
Placenta	11.9 nTPM

Intestinal goblet cells	40.0 nTPM
Colon	48.6 nTPM
Rectum	41.4 nTPM
Small intestine	29.9 nTPM

Macrophages	17.9 nTPM
Adipose tissue	37.8 nTPM
Endometrium	29.4 nTPM
Spleen	24.9 nTPM
Ovary	23.4 nTPM
Skeletal muscle	22.9 nTPM
Breast	20.6 nTPM
Esophagus	20.4 nTPM
Stomach	17.6 nTPM
Testis	14.0 nTPM
Lung	13.2 nTPM
Prostate	12.6 nTPM
Bone marrow	12.5 nTPM
Kidney	11.4 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	20.5 nTPM
Small intestine	26.3 nTPM
Rectum	25.4 nTPM
Colon	9.9 nTPM

Plasma cells	32.2 nTPM
Adipose tissue	44.6 nTPM
Spleen	33.4 nTPM
Esophagus	30.7 nTPM
Stomach	29.3 nTPM
Bone marrow	23.0 nTPM

Respiratory ciliated cells	27.8 nTPM
Bronchus	33.8 nTPM
Lung	21.9 nTPM

Smooth muscle cells	19.3 nTPM
Endometrium	37.9 nTPM
Adipose tissue	26.3 nTPM
Prostate	23.7 nTPM
Ovary	22.4 nTPM
Breast	20.6 nTPM
Esophagus	17.0 nTPM
Skeletal muscle	16.9 nTPM
Skin	15.3 nTPM
Heart muscle	13.9 nTPM
Pancreas	10.7 nTPM
Bronchus	7.5 nTPM

T-cells	20.0 nTPM
Adipose tissue	46.6 nTPM
Endometrium	36.9 nTPM
Breast	31.7 nTPM
Skeletal muscle	30.9 nTPM
Lymph node	22.5 nTPM
Colon	22.3 nTPM
Esophagus	19.7 nTPM
Ovary	17.8 nTPM
Spleen	15.7 nTPM
PBMC	15.6 nTPM
Bone marrow	15.6 nTPM
Stomach	14.9 nTPM
Skin	12.9 nTPM
Liver	10.7 nTPM
Lung	10.6 nTPM
Kidney	10.2 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	39.6 nTPM
Skin	39.6 nTPM

Basal prostatic cells	16.4 nTPM
Prostate	16.4 nTPM

Basal respiratory cells	13.7 nTPM
Bronchus	13.7 nTPM

Basal squamous epithelial cells	29.6 nTPM
Esophagus	29.6 nTPM

Undifferentiated cells	28.4 nTPM
Rectum	33.9 nTPM
Small intestine	26.3 nTPM
Colon	25.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC