Single cell type - YY1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YY1
Gene descriptionⁱ Full gene name according to HGNC.	YY1 transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

YY1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.66
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B	0.6450	10
SET	SET nuclear proto-oncogene	0.6189	39
SMNDC1	Survival motor neuron domain containing 1	0.6154	10
GTF3C4	General transcription factor IIIC subunit 4	0.5657	10
OSBP	Oxysterol binding protein	0.5434	10
PURB	Purine rich element binding protein B	0.5398	10
CTBP1	C-terminal binding protein 1	0.5251	65
HNRNPD	Heterogeneous nuclear ribonucleoprotein D	0.5250	10
MSL1	MSL complex subunit 1	0.5191	10
WAC	WW domain containing adaptor with coiled-coil	0.5165	44
SLC38A2	Solute carrier family 38 member 2	0.5118	7
RCOR1	REST corepressor 1	0.5107	44
SP3	Sp3 transcription factor	0.5091	59
ACBD3	Acyl-CoA binding domain containing 3	0.5084	36
ALYREF	Aly/REF export factor	0.5052	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	116.0 nTPM
Adipose tissue	136.0 nTPM
Breast	95.9 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	66.8 nTPM
Lung	66.8 nTPM

Astrocytes	23.8 nTPM
Brain	23.8 nTPM

B-cells	102.4 nTPM
Adipose tissue	176.5 nTPM
Lymph node	153.3 nTPM
PBMC	128.5 nTPM
Colon	100.6 nTPM
Spleen	97.6 nTPM
Breast	88.2 nTPM
Liver	82.7 nTPM
Bone marrow	80.1 nTPM
Stomach	73.2 nTPM
Kidney	42.9 nTPM

Basal squamous epithelial cells	211.7 nTPM
Esophagus	211.7 nTPM

Dendritic cells	147.4 nTPM
Adipose tissue	223.7 nTPM
Breast	122.8 nTPM
PBMC	95.6 nTPM

Endothelial cells	115.7 nTPM
Prostate	208.6 nTPM
Endometrium	167.2 nTPM
Skin	166.4 nTPM
Esophagus	136.9 nTPM
Eye	130.2 nTPM
Liver	121.1 nTPM
Ovary	118.9 nTPM
Breast	116.1 nTPM
Skeletal muscle	109.2 nTPM
Testis	102.2 nTPM
Placenta	92.1 nTPM
Heart muscle	74.8 nTPM
Pancreas	38.6 nTPM
Lung	37.4 nTPM

Enteroendocrine cells	110.1 nTPM
Colon	127.9 nTPM
Rectum	92.2 nTPM

Erythroid cells	125.4 nTPM
Bone marrow	127.8 nTPM
Liver	123.0 nTPM

Fibroblasts	106.7 nTPM
Prostate	205.2 nTPM
Skin	154.9 nTPM
Adipose tissue	148.4 nTPM
Ovary	107.3 nTPM
Breast	97.3 nTPM
Skeletal muscle	94.5 nTPM
Placenta	88.9 nTPM
Esophagus	86.4 nTPM
Heart muscle	79.0 nTPM
Lung	65.9 nTPM
Stomach	46.0 nTPM

Intestinal goblet cells	108.8 nTPM
Colon	163.7 nTPM
Rectum	89.8 nTPM
Small intestine	72.9 nTPM

Macrophages	121.6 nTPM
Adipose tissue	197.3 nTPM
Prostate	165.1 nTPM
Esophagus	146.3 nTPM
Ovary	144.9 nTPM
Spleen	144.1 nTPM
Endometrium	134.0 nTPM
Skeletal muscle	124.5 nTPM
Testis	114.5 nTPM
Bone marrow	111.2 nTPM
PBMC	109.1 nTPM
Kidney	106.6 nTPM
Breast	100.3 nTPM
Stomach	99.6 nTPM
Lung	67.7 nTPM
Pancreas	58.7 nTPM

Paneth cells	95.5 nTPM
Colon	102.1 nTPM
Rectum	98.1 nTPM
Small intestine	86.3 nTPM

Plasma cells	125.0 nTPM
Esophagus	160.2 nTPM
Adipose tissue	156.1 nTPM
Bone marrow	112.1 nTPM
Spleen	106.7 nTPM
Stomach	90.2 nTPM

Cholangiocytes	92.9 nTPM
Liver	92.9 nTPM

Collecting duct cells	68.0 nTPM
Kidney	68.0 nTPM

Cone photoreceptor cells	81.3 nTPM
Eye	81.3 nTPM

Cytotrophoblasts	118.6 nTPM
Placenta	118.6 nTPM

Respiratory ciliated cells	47.6 nTPM
Bronchus	55.9 nTPM
Lung	39.4 nTPM

Smooth muscle cells	124.3 nTPM
Bronchus	174.0 nTPM
Prostate	160.7 nTPM
Skin	148.9 nTPM
Adipose tissue	143.5 nTPM
Endometrium	140.8 nTPM
Ovary	132.4 nTPM
Heart muscle	106.4 nTPM
Skeletal muscle	98.3 nTPM
Breast	93.2 nTPM
Esophagus	89.9 nTPM
Pancreas	79.3 nTPM

T-cells	124.8 nTPM
Adipose tissue	239.5 nTPM
Skeletal muscle	173.1 nTPM
Endometrium	157.5 nTPM
Esophagus	157.2 nTPM
Skin	156.1 nTPM
Lymph node	151.9 nTPM
Colon	130.7 nTPM
PBMC	127.5 nTPM
Breast	127.0 nTPM
Spleen	107.4 nTPM
Ovary	104.5 nTPM
Prostate	104.2 nTPM
Liver	95.1 nTPM
Kidney	87.6 nTPM
Bone marrow	76.9 nTPM
Stomach	76.6 nTPM
Lung	48.6 nTPM

Undifferentiated cells	118.7 nTPM
Colon	145.6 nTPM
Rectum	108.3 nTPM
Small intestine	102.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC