Single cell type - CEP126 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CEP126
Gene descriptionⁱ Full gene name according to HGNC.	Centrosomal protein 126
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Ciliated cells - Cilium organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Endometrial ciliated cells, Respiratory ciliated cells, Horizontal cells, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, EFO-21)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Endometrial ciliated cells, Respiratory ciliated cells, Horizontal cells, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CEP126 is part of cluster 49 Ciliated cells - Cilium organization with confidenceⁱ 1
457 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCDC191	Coiled-coil domain containing 191	0.7173	49
CATSPERE	Catsper channel auxiliary subunit epsilon	0.6684	49
CABCOCO1	Ciliary associated calcium binding coiled-coil 1	0.6522	49
PRR29	Proline rich 29	0.6434	49
CFAP97D2	CFAP97 domain containing 2	0.6419	49
NEK5	NIMA related kinase 5	0.6363	49
CFAP157	Cilia and flagella associated protein 157	0.6346	49
DEUP1	Deuterosome assembly protein 1	0.6340	49
DRC3	Dynein regulatory complex subunit 3	0.6196	49
LRRC74B	Leucine rich repeat containing 74B	0.6189	49
DNAH12	Dynein axonemal heavy chain 12	0.6153	49
AC007906.2	Novel protein	0.6148	49
LDLRAD1	Low density lipoprotein receptor class A domain containing 1	0.6133	49
C21orf58	Chromosome 21 open reading frame 58	0.6093	49
CFAP57	Cilia and flagella associated protein 57	0.5939	49

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.7 nTPM
Adipose tissue	8.2 nTPM
Breast	5.1 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	6.7 nTPM
Lung	6.7 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	7.2 nTPM
Adipose tissue	27.0 nTPM
PBMC	11.5 nTPM
Stomach	10.5 nTPM
Spleen	6.2 nTPM
Lymph node	4.9 nTPM
Kidney	4.8 nTPM
Bone marrow	4.1 nTPM
Liver	3.0 nTPM
Colon	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	20.2 nTPM
PBMC	31.8 nTPM
Adipose tissue	19.9 nTPM
Breast	8.8 nTPM

Endothelial cells	4.0 nTPM
Lung	9.3 nTPM
Skeletal muscle	8.1 nTPM
Heart muscle	6.7 nTPM
Testis	5.4 nTPM
Breast	5.3 nTPM
Eye	4.8 nTPM
Liver	4.6 nTPM
Esophagus	4.1 nTPM
Endometrium	3.7 nTPM
Prostate	2.6 nTPM
Ovary	1.2 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM

Fibroblasts	33.4 nTPM
Adipose tissue	79.9 nTPM
Heart muscle	68.4 nTPM
Skeletal muscle	55.1 nTPM
Esophagus	41.9 nTPM
Breast	35.0 nTPM
Stomach	26.7 nTPM
Lung	24.6 nTPM
Ovary	17.8 nTPM
Prostate	11.2 nTPM
Placenta	7.3 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	9.4 nTPM
Rectum	19.2 nTPM
Small intestine	9.1 nTPM
Colon	0.0 nTPM

Macrophages	2.8 nTPM
Skeletal muscle	8.8 nTPM
Lung	7.5 nTPM
Endometrium	5.1 nTPM
Adipose tissue	4.7 nTPM
Esophagus	3.1 nTPM
Testis	2.9 nTPM
Stomach	2.9 nTPM
Prostate	2.2 nTPM
Breast	2.2 nTPM
Spleen	1.0 nTPM
Kidney	0.8 nTPM
Ovary	0.4 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	1.7 nTPM
Rectum	5.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	3.5 nTPM
Adipose tissue	13.0 nTPM
Stomach	2.5 nTPM
Bone marrow	1.7 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	138.5 nTPM
Lung	276.9 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	11.3 nTPM
Adipose tissue	31.7 nTPM
Heart muscle	22.3 nTPM
Endometrium	18.1 nTPM
Skeletal muscle	14.6 nTPM
Breast	13.8 nTPM
Prostate	10.3 nTPM
Ovary	6.8 nTPM
Esophagus	4.6 nTPM
Pancreas	1.8 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	6.3 nTPM
Lung	19.7 nTPM
Skeletal muscle	15.4 nTPM
Endometrium	13.8 nTPM
PBMC	8.8 nTPM
Adipose tissue	8.3 nTPM
Kidney	7.5 nTPM
Liver	7.5 nTPM
Esophagus	6.6 nTPM
Bone marrow	5.0 nTPM
Lymph node	4.6 nTPM
Spleen	4.2 nTPM
Breast	4.0 nTPM
Stomach	1.6 nTPM
Colon	0.0 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Ovary	0.0 nTPM

Basal squamous epithelial cells	5.2 nTPM
Esophagus	5.2 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Cone photoreceptor cells	45.9 nTPM
Eye	45.9 nTPM

Undifferentiated cells	1.7 nTPM
Rectum	3.4 nTPM
Small intestine	1.6 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC