Single cell type - AIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AIP
Gene descriptionⁱ Full gene name according to HGNC.	Aryl hydrocarbon receptor interacting protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AIP is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBXN1	UBX domain protein 1	0.5986	32
HSPA8	Heat shock protein family A (Hsp70) member 8	0.5836	22
CNBP	CCHC-type zinc finger nucleic acid binding protein	0.5606	10
SUMO2	Small ubiquitin like modifier 2	0.5457	10
PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	0.5303	63
POLR3GL	RNA polymerase III subunit GL	0.5277	63
UBE2B	Ubiquitin conjugating enzyme E2 B	0.5266	10
VPS28	VPS28 subunit of ESCRT-I	0.5226	53
ANXA2R	Annexin A2 receptor	0.5217	63
TBRG1	Transforming growth factor beta regulator 1	0.5154	10
IL27RA	Interleukin 27 receptor subunit alpha	0.5148	63
ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese dependent	0.5072	32
TMC8	Transmembrane channel like 8	0.5061	63
GIMAP4	GTPase, IMAP family member 4	0.5057	63
ZMAT5	Zinc finger matrin-type 5	0.5035	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	57.2 nTPM
Breast	65.7 nTPM
Adipose tissue	48.7 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	25.6 nTPM
Lung	25.6 nTPM

Astrocytes	6.8 nTPM
Brain	6.8 nTPM

B-cells	69.4 nTPM
Spleen	83.0 nTPM
Bone marrow	80.1 nTPM
PBMC	77.1 nTPM
Lymph node	72.4 nTPM
Breast	69.6 nTPM
Liver	69.2 nTPM
Stomach	68.6 nTPM
Adipose tissue	67.7 nTPM
Colon	54.3 nTPM
Kidney	52.4 nTPM

Dendritic cells	61.9 nTPM
Breast	75.5 nTPM
Adipose tissue	66.5 nTPM
PBMC	43.8 nTPM

Endothelial cells	54.0 nTPM
Prostate	72.5 nTPM
Liver	71.5 nTPM
Testis	69.3 nTPM
Placenta	67.6 nTPM
Pancreas	65.6 nTPM
Ovary	59.9 nTPM
Breast	56.6 nTPM
Esophagus	56.3 nTPM
Skin	50.1 nTPM
Eye	48.6 nTPM
Skeletal muscle	42.8 nTPM
Lung	37.4 nTPM
Endometrium	35.7 nTPM
Heart muscle	22.8 nTPM

Fibroblasts	51.0 nTPM
Adipose tissue	73.5 nTPM
Placenta	68.7 nTPM
Esophagus	65.9 nTPM
Breast	59.6 nTPM
Prostate	59.3 nTPM
Stomach	50.5 nTPM
Ovary	49.3 nTPM
Skin	48.0 nTPM
Skeletal muscle	46.3 nTPM
Heart muscle	25.0 nTPM
Lung	14.5 nTPM

Intestinal goblet cells	34.7 nTPM
Small intestine	40.1 nTPM
Colon	40.0 nTPM
Rectum	23.9 nTPM

Macrophages	56.1 nTPM
Ovary	89.8 nTPM
Kidney	83.2 nTPM
Testis	77.8 nTPM
Adipose tissue	68.1 nTPM
Breast	67.7 nTPM
Pancreas	63.8 nTPM
Prostate	63.0 nTPM
Bone marrow	52.4 nTPM
Esophagus	48.7 nTPM
Skeletal muscle	47.0 nTPM
Lung	45.1 nTPM
Stomach	43.9 nTPM
Spleen	41.4 nTPM
Endometrium	35.8 nTPM
PBMC	13.6 nTPM

Paneth cells	53.5 nTPM
Colon	79.0 nTPM
Small intestine	52.6 nTPM
Rectum	29.0 nTPM

Plasma cells	50.2 nTPM
Stomach	70.0 nTPM
Bone marrow	54.4 nTPM
Spleen	52.0 nTPM
Adipose tissue	43.9 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	17.4 nTPM
Bronchus	20.2 nTPM
Lung	14.6 nTPM

Smooth muscle cells	86.5 nTPM
Bronchus	330.8 nTPM
Prostate	82.5 nTPM
Breast	78.8 nTPM
Esophagus	71.3 nTPM
Heart muscle	67.0 nTPM
Skeletal muscle	62.3 nTPM
Ovary	57.2 nTPM
Pancreas	56.5 nTPM
Adipose tissue	56.4 nTPM
Skin	53.0 nTPM
Endometrium	35.0 nTPM

T-cells	90.6 nTPM
Ovary	137.9 nTPM
Kidney	123.9 nTPM
Liver	109.8 nTPM
Bone marrow	109.8 nTPM
PBMC	109.5 nTPM
Lymph node	105.4 nTPM
Skin	105.0 nTPM
Spleen	102.0 nTPM
Stomach	88.8 nTPM
Breast	88.3 nTPM
Colon	86.0 nTPM
Adipose tissue	83.5 nTPM
Prostate	66.3 nTPM
Lung	62.3 nTPM
Esophagus	58.9 nTPM
Skeletal muscle	56.7 nTPM
Endometrium	46.2 nTPM

Basal keratinocytes	30.3 nTPM
Skin	30.3 nTPM

Basal respiratory cells	54.2 nTPM
Bronchus	54.2 nTPM

Basal squamous epithelial cells	31.9 nTPM
Esophagus	31.9 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Undifferentiated cells	25.4 nTPM
Small intestine	28.1 nTPM
Colon	24.7 nTPM
Rectum	23.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC