Single cell type - PIK3CD - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIK3CD
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (dendritic cells, T-cells, Kupffer cells, NK-cells, Microglial cells, granulocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2, NB-4, REH, THP-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (dendritic cells, T-cells, Kupffer cells, NK-cells, Microglial cells, granulocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIK3CD is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMC8	Transmembrane channel like 8	0.7984	63
UBASH3A	Ubiquitin associated and SH3 domain containing A	0.7367	58
RASAL3	RAS protein activator like 3	0.7291	63
IL27RA	Interleukin 27 receptor subunit alpha	0.7238	63
DENND1C	DENN domain containing 1C	0.7162	63
CD8B	CD8b molecule	0.7129	63
LCK	LCK proto-oncogene, Src family tyrosine kinase	0.7107	63
APBB1IP	Amyloid beta precursor protein binding family B member 1 interacting protein	0.6988	63
RGL4	Ral guanine nucleotide dissociation stimulator like 4	0.6859	63
SLFN12L	Schlafen family member 12 like	0.6850	63
JAK3	Janus kinase 3	0.6725	58
FLT3LG	Fms related receptor tyrosine kinase 3 ligand	0.6679	58
TBC1D10C	TBC1 domain family member 10C	0.6658	63
CD3D	CD3d molecule	0.6582	63
ANXA2R	Annexin A2 receptor	0.6521	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.7 nTPM
Breast	2.0 nTPM
Adipose tissue	1.4 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	13.4 nTPM
Lung	13.4 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	22.2 nTPM
Bone marrow	35.1 nTPM
Spleen	33.6 nTPM
Stomach	31.4 nTPM
Lymph node	31.2 nTPM
Breast	22.8 nTPM
PBMC	18.6 nTPM
Adipose tissue	17.6 nTPM
Colon	12.8 nTPM
Kidney	9.5 nTPM
Liver	9.4 nTPM

Dendritic cells	44.0 nTPM
PBMC	59.8 nTPM
Breast	46.7 nTPM
Adipose tissue	25.5 nTPM

Endothelial cells	2.7 nTPM
Eye	9.7 nTPM
Heart muscle	7.2 nTPM
Lung	6.2 nTPM
Prostate	2.0 nTPM
Skeletal muscle	2.0 nTPM
Liver	1.8 nTPM
Testis	1.8 nTPM
Ovary	1.8 nTPM
Breast	1.8 nTPM
Esophagus	1.6 nTPM
Skin	0.8 nTPM
Endometrium	0.5 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	2.9 nTPM
Heart muscle	8.5 nTPM
Lung	6.7 nTPM
Breast	3.8 nTPM
Stomach	3.0 nTPM
Skin	2.0 nTPM
Skeletal muscle	1.8 nTPM
Placenta	1.5 nTPM
Prostate	1.5 nTPM
Esophagus	1.5 nTPM
Ovary	1.2 nTPM
Adipose tissue	0.9 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	23.1 nTPM
Stomach	58.6 nTPM
Spleen	43.5 nTPM
Bone marrow	36.3 nTPM
Ovary	25.1 nTPM
Breast	25.1 nTPM
Esophagus	23.6 nTPM
Skeletal muscle	23.5 nTPM
Kidney	21.1 nTPM
Endometrium	20.1 nTPM
Lung	19.8 nTPM
Testis	19.2 nTPM
Adipose tissue	13.0 nTPM
Pancreas	10.2 nTPM
Prostate	8.1 nTPM
PBMC	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	8.2 nTPM
Adipose tissue	21.9 nTPM
Bone marrow	11.5 nTPM
Spleen	5.6 nTPM
Stomach	2.1 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	3.3 nTPM
Bronchus	5.1 nTPM
Lung	1.5 nTPM

Smooth muscle cells	4.7 nTPM
Esophagus	9.3 nTPM
Pancreas	9.0 nTPM
Ovary	7.3 nTPM
Skeletal muscle	5.5 nTPM
Skin	5.2 nTPM
Breast	4.4 nTPM
Bronchus	2.9 nTPM
Endometrium	2.8 nTPM
Heart muscle	2.5 nTPM
Prostate	1.5 nTPM
Adipose tissue	1.2 nTPM

T-cells	37.1 nTPM
Bone marrow	66.8 nTPM
Lymph node	64.2 nTPM
Stomach	54.6 nTPM
Spleen	52.4 nTPM
Breast	44.3 nTPM
Ovary	42.2 nTPM
Liver	40.9 nTPM
PBMC	39.7 nTPM
Esophagus	39.3 nTPM
Endometrium	36.0 nTPM
Lung	33.4 nTPM
Skeletal muscle	32.4 nTPM
Colon	28.0 nTPM
Kidney	19.8 nTPM
Adipose tissue	18.7 nTPM
Skin	12.4 nTPM
Prostate	4.7 nTPM

Basal prostatic cells	2.2 nTPM
Prostate	2.2 nTPM

Basal squamous epithelial cells	4.0 nTPM
Esophagus	4.0 nTPM

Cytotrophoblasts	0.3 nTPM
Placenta	0.3 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Undifferentiated cells	0.2 nTPM
Colon	0.3 nTPM
Small intestine	0.2 nTPM
Rectum	0.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC