Single cell type - MANSC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MANSC1
Gene descriptionⁱ Full gene name according to HGNC.	MANSC domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mucus-secreting cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HUVEC TERT2, OE19, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MANSC1 is part of cluster 27 Mucus-secreting cells - Mucin production with confidenceⁱ 1
121 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NPDC1	Neural proliferation, differentiation and control 1	0.6545	27
STX19	Syntaxin 19	0.6077	27
CANT1	Calcium activated nucleotidase 1	0.6027	27
CRACR2B	Calcium release activated channel regulator 2B	0.5769	35
CREB3L1	CAMP responsive element binding protein 3 like 1	0.5718	27
TSPAN13	Tetraspanin 13	0.5562	27
LRRC31	Leucine rich repeat containing 31	0.5559	27
SH3BGRL2	SH3 domain binding glutamate rich protein like 2	0.5423	53
MKRN2OS	MKRN2 opposite strand	0.5403	27
CLDN8	Claudin 8	0.5391	53
TRIOBP	TRIO and F-actin binding protein	0.5315	40
ZNF799	Zinc finger protein 799	0.5305	47
TFF3	Trefoil factor 3	0.5232	27
EPN3	Epsin 3	0.5186	47
GALNT12	Polypeptide N-acetylgalactosaminyltransferase 12	0.5168	27

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.0 nTPM
Adipose tissue	32.9 nTPM
Breast	25.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	21.2 nTPM
Lung	21.2 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	3.3 nTPM
Kidney	9.5 nTPM
Liver	8.6 nTPM
Breast	5.3 nTPM
Colon	3.2 nTPM
Adipose tissue	1.5 nTPM
PBMC	1.4 nTPM
Lymph node	0.9 nTPM
Stomach	0.9 nTPM
Bone marrow	0.8 nTPM
Spleen	0.7 nTPM

Dendritic cells	4.5 nTPM
PBMC	8.0 nTPM
Breast	3.3 nTPM
Adipose tissue	2.3 nTPM

Endothelial cells	28.8 nTPM
Testis	50.7 nTPM
Placenta	44.9 nTPM
Esophagus	39.2 nTPM
Ovary	36.5 nTPM
Skeletal muscle	31.3 nTPM
Endometrium	30.6 nTPM
Breast	28.4 nTPM
Heart muscle	27.5 nTPM
Pancreas	27.0 nTPM
Liver	25.7 nTPM
Lung	21.8 nTPM
Prostate	15.1 nTPM
Skin	14.8 nTPM
Eye	8.9 nTPM

Fibroblasts	10.4 nTPM
Stomach	16.3 nTPM
Adipose tissue	16.2 nTPM
Skeletal muscle	15.3 nTPM
Esophagus	13.0 nTPM
Placenta	12.9 nTPM
Breast	11.0 nTPM
Skin	8.6 nTPM
Heart muscle	7.1 nTPM
Ovary	6.7 nTPM
Prostate	3.6 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	33.4 nTPM
Rectum	40.5 nTPM
Small intestine	39.1 nTPM
Colon	20.8 nTPM

Macrophages	2.0 nTPM
Lung	5.7 nTPM
Skeletal muscle	5.6 nTPM
Testis	4.6 nTPM
Breast	3.0 nTPM
Bone marrow	2.5 nTPM
Kidney	2.3 nTPM
Endometrium	2.0 nTPM
Adipose tissue	1.7 nTPM
Esophagus	1.6 nTPM
Ovary	1.4 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	25.2 nTPM
Rectum	32.4 nTPM
Small intestine	30.0 nTPM
Colon	13.2 nTPM

Plasma cells	1.0 nTPM
Adipose tissue	2.7 nTPM
Bone marrow	1.7 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	18.1 nTPM
Lung	20.4 nTPM
Bronchus	15.7 nTPM

Smooth muscle cells	6.5 nTPM
Heart muscle	12.6 nTPM
Breast	8.8 nTPM
Bronchus	8.4 nTPM
Esophagus	7.8 nTPM
Skeletal muscle	6.4 nTPM
Adipose tissue	6.1 nTPM
Endometrium	6.0 nTPM
Prostate	5.3 nTPM
Skin	4.6 nTPM
Ovary	3.8 nTPM
Pancreas	1.5 nTPM

T-cells	3.0 nTPM
PBMC	6.7 nTPM
Lung	6.1 nTPM
Breast	5.8 nTPM
Liver	5.6 nTPM
Prostate	4.7 nTPM
Endometrium	4.4 nTPM
Kidney	4.2 nTPM
Skeletal muscle	4.2 nTPM
Ovary	2.2 nTPM
Adipose tissue	1.8 nTPM
Lymph node	1.7 nTPM
Spleen	1.0 nTPM
Skin	0.9 nTPM
Bone marrow	0.7 nTPM
Colon	0.5 nTPM
Stomach	0.3 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	4.0 nTPM
Skin	4.0 nTPM

Basal respiratory cells	7.2 nTPM
Bronchus	7.2 nTPM

Basal squamous epithelial cells	6.2 nTPM
Esophagus	6.2 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Undifferentiated cells	26.5 nTPM
Rectum	36.0 nTPM
Small intestine	26.8 nTPM
Colon	16.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC