Single cell type - CCNG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCNG1
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin G1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCNG1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ECSIT	ECSIT signaling integrator	0.5497	39
UXT	Ubiquitously expressed prefoldin like chaperone	0.5304	32
LETMD1	LETM1 domain containing 1	0.5220	32
OST4	Oligosaccharyltransferase complex subunit 4, non-catalytic	0.5217	32
ABHD14B	Abhydrolase domain containing 14B	0.5181	67
TMEM106C	Transmembrane protein 106C	0.5157	45
MRPL11	Mitochondrial ribosomal protein L11	0.5135	39
UQCRH	Ubiquinol-cytochrome c reductase hinge protein	0.5084	39
EIF3K	Eukaryotic translation initiation factor 3 subunit K	0.5067	32
ABO	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	0.5037	45
COX7C	Cytochrome c oxidase subunit 7C	0.5017	39
DEFA6	Defensin alpha 6	0.4898	53
FAM122B	Family with sequence similarity 122B	0.4809	51
CASP6	Caspase 6	0.4796	40
LGALS2	Galectin 2	0.4735	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.8 nTPM
Breast	21.2 nTPM
Adipose tissue	20.4 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	20.0 nTPM
Lung	20.0 nTPM

Astrocytes	7.5 nTPM
Brain	7.5 nTPM

B-cells	67.3 nTPM
Colon	91.1 nTPM
Spleen	91.1 nTPM
Kidney	85.7 nTPM
Stomach	75.4 nTPM
Liver	66.4 nTPM
Lymph node	63.9 nTPM
Bone marrow	62.1 nTPM
PBMC	54.3 nTPM
Adipose tissue	48.2 nTPM
Breast	34.7 nTPM

Basal squamous epithelial cells	103.0 nTPM
Esophagus	103.0 nTPM

Dendritic cells	49.8 nTPM
Adipose tissue	52.8 nTPM
PBMC	51.8 nTPM
Breast	44.8 nTPM

Endothelial cells	43.5 nTPM
Liver	94.5 nTPM
Prostate	77.2 nTPM
Testis	66.3 nTPM
Skin	61.0 nTPM
Placenta	57.4 nTPM
Breast	35.7 nTPM
Ovary	35.3 nTPM
Endometrium	32.8 nTPM
Lung	28.1 nTPM
Heart muscle	26.1 nTPM
Skeletal muscle	26.0 nTPM
Esophagus	25.3 nTPM
Eye	24.2 nTPM
Pancreas	19.3 nTPM

Fibroblasts	57.1 nTPM
Placenta	92.9 nTPM
Skin	85.7 nTPM
Ovary	71.5 nTPM
Prostate	61.0 nTPM
Adipose tissue	55.2 nTPM
Breast	50.0 nTPM
Heart muscle	46.1 nTPM
Esophagus	45.8 nTPM
Lung	42.4 nTPM
Skeletal muscle	40.1 nTPM
Stomach	37.1 nTPM

Intestinal goblet cells	113.2 nTPM
Rectum	155.6 nTPM
Small intestine	108.8 nTPM
Colon	75.1 nTPM

Macrophages	60.8 nTPM
PBMC	300.1 nTPM
Prostate	83.7 nTPM
Spleen	63.2 nTPM
Ovary	56.2 nTPM
Kidney	53.7 nTPM
Bone marrow	53.7 nTPM
Testis	51.7 nTPM
Adipose tissue	46.9 nTPM
Esophagus	37.7 nTPM
Stomach	35.1 nTPM
Skeletal muscle	34.8 nTPM
Breast	30.2 nTPM
Endometrium	25.6 nTPM
Lung	20.9 nTPM
Pancreas	17.8 nTPM

Paneth cells	80.2 nTPM
Rectum	153.4 nTPM
Small intestine	67.5 nTPM
Colon	19.7 nTPM

Plasma cells	63.5 nTPM
Stomach	84.4 nTPM
Spleen	82.9 nTPM
Bone marrow	77.4 nTPM
Esophagus	43.0 nTPM
Adipose tissue	29.7 nTPM

Respiratory ciliated cells	11.2 nTPM
Bronchus	19.6 nTPM
Lung	2.9 nTPM

Smooth muscle cells	73.4 nTPM
Bronchus	281.9 nTPM
Prostate	87.6 nTPM
Ovary	85.0 nTPM
Skin	82.3 nTPM
Pancreas	56.0 nTPM
Heart muscle	50.7 nTPM
Adipose tissue	38.7 nTPM
Breast	36.2 nTPM
Skeletal muscle	33.7 nTPM
Esophagus	31.0 nTPM
Endometrium	24.4 nTPM

Collecting duct cells	36.8 nTPM
Kidney	36.8 nTPM

Cone photoreceptor cells	0.0 nTPM
Eye	0.0 nTPM

Cytotrophoblasts	138.7 nTPM
Placenta	138.7 nTPM

Early spermatids	8.1 nTPM
Testis	8.1 nTPM

T-cells	76.4 nTPM
Prostate	146.8 nTPM
Colon	115.4 nTPM
Kidney	113.6 nTPM
PBMC	110.6 nTPM
Skin	98.1 nTPM
Spleen	96.3 nTPM
Lymph node	90.6 nTPM
Liver	81.8 nTPM
Bone marrow	73.0 nTPM
Stomach	71.8 nTPM
Adipose tissue	61.9 nTPM
Ovary	57.8 nTPM
Breast	49.2 nTPM
Esophagus	45.9 nTPM
Skeletal muscle	35.5 nTPM
Endometrium	29.5 nTPM
Lung	21.3 nTPM

Undifferentiated cells	182.7 nTPM
Small intestine	221.7 nTPM
Rectum	190.6 nTPM
Colon	135.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC