Single cell type - CASP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CASP6
Gene descriptionⁱ Full gene name according to HGNC.	Caspase 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CASP6 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IHH	Indian hedgehog signaling molecule	0.7571	40
CES3	Carboxylesterase 3	0.7565	53
NR5A2	Nuclear receptor subfamily 5 group A member 2	0.6663	40
ALDH18A1	Aldehyde dehydrogenase 18 family member A1	0.6551	40
LRP5	LDL receptor related protein 5	0.6514	40
BTBD2	BTB domain containing 2	0.6417	40
GSR	Glutathione-disulfide reductase	0.6401	40
LRAT	Lecithin retinol acyltransferase	0.6169	40
BMP3	Bone morphogenetic protein 3	0.6162	40
CRYGD	Crystallin gamma D	0.6129	40
DHH	Desert hedgehog signaling molecule	0.6112	40
GOLPH3L	Golgi phosphoprotein 3 like	0.6082	40
ARSD	Arylsulfatase D	0.6077	53
DEFA6	Defensin alpha 6	0.6062	53
TCEA3	Transcription elongation factor A3	0.6048	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.5 nTPM
Breast	13.3 nTPM
Adipose tissue	7.8 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	14.6 nTPM
Lung	14.6 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	7.7 nTPM
Kidney	14.3 nTPM
Liver	13.4 nTPM
Colon	8.0 nTPM
Stomach	7.7 nTPM
Lymph node	7.6 nTPM
Spleen	6.9 nTPM
PBMC	5.7 nTPM
Bone marrow	4.9 nTPM
Adipose tissue	4.5 nTPM
Breast	4.0 nTPM

Dendritic cells	7.6 nTPM
Breast	9.1 nTPM
PBMC	8.0 nTPM
Adipose tissue	5.7 nTPM

Endothelial cells	12.2 nTPM
Esophagus	20.7 nTPM
Placenta	18.8 nTPM
Endometrium	18.8 nTPM
Testis	18.7 nTPM
Breast	16.3 nTPM
Pancreas	15.5 nTPM
Skeletal muscle	13.3 nTPM
Ovary	13.0 nTPM
Skin	10.6 nTPM
Liver	7.3 nTPM
Eye	6.5 nTPM
Prostate	5.6 nTPM
Heart muscle	5.3 nTPM
Lung	0.0 nTPM

Fibroblasts	13.4 nTPM
Ovary	23.7 nTPM
Lung	17.9 nTPM
Esophagus	15.4 nTPM
Skeletal muscle	14.4 nTPM
Placenta	13.9 nTPM
Adipose tissue	13.5 nTPM
Heart muscle	13.1 nTPM
Breast	11.9 nTPM
Skin	10.0 nTPM
Stomach	7.4 nTPM
Prostate	6.5 nTPM

Intestinal goblet cells	53.9 nTPM
Small intestine	55.0 nTPM
Rectum	53.8 nTPM
Colon	52.9 nTPM

Macrophages	14.5 nTPM
PBMC	54.6 nTPM
Ovary	23.9 nTPM
Pancreas	20.4 nTPM
Breast	15.9 nTPM
Skeletal muscle	14.6 nTPM
Lung	13.8 nTPM
Endometrium	11.3 nTPM
Kidney	9.9 nTPM
Esophagus	9.4 nTPM
Stomach	8.8 nTPM
Prostate	8.1 nTPM
Testis	8.1 nTPM
Bone marrow	7.5 nTPM
Adipose tissue	6.5 nTPM
Spleen	5.2 nTPM

Paneth cells	52.5 nTPM
Rectum	71.1 nTPM
Small intestine	60.1 nTPM
Colon	26.4 nTPM

Plasma cells	8.8 nTPM
Bone marrow	18.2 nTPM
Spleen	16.0 nTPM
Stomach	7.2 nTPM
Adipose tissue	2.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	18.6 nTPM
Lung	27.7 nTPM
Bronchus	9.6 nTPM

Smooth muscle cells	12.3 nTPM
Ovary	53.3 nTPM
Breast	11.9 nTPM
Endometrium	11.3 nTPM
Pancreas	11.2 nTPM
Esophagus	7.8 nTPM
Heart muscle	7.6 nTPM
Adipose tissue	7.5 nTPM
Skin	7.0 nTPM
Bronchus	6.6 nTPM
Prostate	6.0 nTPM
Skeletal muscle	4.6 nTPM

T-cells	17.5 nTPM
Ovary	35.6 nTPM
PBMC	23.3 nTPM
Kidney	22.0 nTPM
Lung	21.3 nTPM
Esophagus	19.7 nTPM
Breast	19.6 nTPM
Prostate	19.0 nTPM
Adipose tissue	18.5 nTPM
Lymph node	16.1 nTPM
Spleen	16.1 nTPM
Skeletal muscle	15.7 nTPM
Bone marrow	14.9 nTPM
Skin	14.3 nTPM
Liver	12.7 nTPM
Endometrium	10.3 nTPM
Stomach	9.9 nTPM
Colon	8.5 nTPM

Basal keratinocytes	10.8 nTPM
Skin	10.8 nTPM

Basal prostatic cells	10.2 nTPM
Prostate	10.2 nTPM

Basal respiratory cells	26.7 nTPM
Bronchus	26.7 nTPM

Basal squamous epithelial cells	12.0 nTPM
Esophagus	12.0 nTPM

Undifferentiated cells	74.2 nTPM
Small intestine	84.0 nTPM
Colon	74.2 nTPM
Rectum	64.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC