Single cell type - ACAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACAP2
Gene descriptionⁱ Full gene name according to HGNC.	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACAP2 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAB24	RAB24, member RAS oncogene family	0.6604	59
NBPF26	NBPF member 26	0.6128	59
ATP6V0C	ATPase H+ transporting V0 subunit c	0.5872	59
MOSPD2	Motile sperm domain containing 2	0.5870	10
RHOA	Ras homolog family member A	0.5750	10
SP110	SP110 nuclear body protein	0.5496	57
TLR1	Toll like receptor 1	0.5428	57
CR1	Complement C3b/C4b receptor 1 (Knops blood group)	0.5410	57
RNASEK	Ribonuclease K	0.5360	59
TNFSF13	TNF superfamily member 13	0.5331	11
CYBB	Cytochrome b-245 beta chain	0.5320	19
TRAPPC5	Trafficking protein particle complex 5	0.5298	59
SCIMP	SLP adaptor and CSK interacting membrane protein	0.5239	57
POU2F2	POU class 2 homeobox 2	0.5208	57
RNF111	Ring finger protein 111	0.5168	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	110.7 nTPM
Breast	114.0 nTPM
Adipose tissue	107.3 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	40.9 nTPM
Lung	40.9 nTPM

Astrocytes	103.8 nTPM
Brain	103.8 nTPM

Basal keratinocytes	44.5 nTPM
Skin	44.5 nTPM

B-cells	103.1 nTPM
Lymph node	178.5 nTPM
Bone marrow	151.2 nTPM
Stomach	139.9 nTPM
Spleen	131.5 nTPM
Adipose tissue	101.3 nTPM
Breast	95.0 nTPM
Colon	78.3 nTPM
PBMC	72.9 nTPM
Kidney	42.9 nTPM
Liver	39.5 nTPM

Dendritic cells	101.9 nTPM
PBMC	111.6 nTPM
Breast	101.6 nTPM
Adipose tissue	92.4 nTPM

Endothelial cells	74.1 nTPM
Heart muscle	143.1 nTPM
Esophagus	109.8 nTPM
Lung	102.9 nTPM
Breast	87.6 nTPM
Prostate	82.9 nTPM
Skeletal muscle	79.9 nTPM
Ovary	69.4 nTPM
Liver	66.9 nTPM
Endometrium	65.4 nTPM
Skin	60.3 nTPM
Testis	54.8 nTPM
Eye	50.2 nTPM
Placenta	44.9 nTPM
Pancreas	19.3 nTPM

Fibroblasts	62.2 nTPM
Esophagus	100.3 nTPM
Adipose tissue	82.1 nTPM
Breast	75.8 nTPM
Heart muscle	71.7 nTPM
Stomach	63.9 nTPM
Skeletal muscle	58.7 nTPM
Skin	54.6 nTPM
Lung	49.2 nTPM
Prostate	49.2 nTPM
Ovary	48.2 nTPM
Placenta	30.7 nTPM

Intestinal goblet cells	44.4 nTPM
Colon	47.2 nTPM
Small intestine	46.9 nTPM
Rectum	39.1 nTPM

Macrophages	110.8 nTPM
Spleen	195.9 nTPM
Stomach	193.4 nTPM
Bone marrow	187.4 nTPM
Esophagus	151.1 nTPM
Adipose tissue	128.3 nTPM
Skeletal muscle	126.9 nTPM
Lung	121.7 nTPM
Breast	110.3 nTPM
Kidney	103.7 nTPM
Ovary	97.7 nTPM
Testis	81.9 nTPM
Endometrium	74.2 nTPM
Pancreas	56.2 nTPM
Prostate	33.2 nTPM
PBMC	0.0 nTPM

Paneth cells	70.7 nTPM
Colon	108.7 nTPM
Rectum	54.7 nTPM
Small intestine	48.8 nTPM

Plasma cells	67.6 nTPM
Adipose tissue	78.7 nTPM
Bone marrow	72.5 nTPM
Spleen	69.2 nTPM
Stomach	68.4 nTPM
Esophagus	49.4 nTPM

Respiratory ciliated cells	45.1 nTPM
Lung	48.1 nTPM
Bronchus	42.1 nTPM

Smooth muscle cells	61.4 nTPM
Bronchus	102.0 nTPM
Esophagus	93.1 nTPM
Adipose tissue	82.4 nTPM
Heart muscle	67.7 nTPM
Skeletal muscle	65.5 nTPM
Breast	64.4 nTPM
Endometrium	54.2 nTPM
Prostate	42.2 nTPM
Skin	40.1 nTPM
Ovary	38.7 nTPM
Pancreas	24.9 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	31.3 nTPM
Kidney	31.3 nTPM

Cone photoreceptor cells	77.2 nTPM
Eye	77.2 nTPM

Cytotrophoblasts	20.2 nTPM
Placenta	20.2 nTPM

T-cells	85.1 nTPM
Esophagus	137.6 nTPM
Bone marrow	118.7 nTPM
Lymph node	116.9 nTPM
Stomach	112.5 nTPM
Skeletal muscle	108.2 nTPM
Spleen	106.3 nTPM
Breast	93.0 nTPM
Adipose tissue	91.9 nTPM
Lung	80.5 nTPM
Endometrium	75.1 nTPM
Ovary	71.2 nTPM
PBMC	70.9 nTPM
Skin	62.7 nTPM
Colon	54.2 nTPM
Kidney	52.0 nTPM
Liver	51.9 nTPM
Prostate	42.6 nTPM

Undifferentiated cells	37.6 nTPM
Colon	40.9 nTPM
Small intestine	36.1 nTPM
Rectum	35.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC