Single cell type - GORASP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GORASP1
Gene descriptionⁱ Full gene name according to HGNC.	Golgi reassembly stacking protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GORASP1 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MMEL1	Membrane metalloendopeptidase like 1	0.6665	29
PRSS54	Serine protease 54	0.6416	29
CCDC126	Coiled-coil domain containing 126	0.6393	34
NPIPB15	Nuclear pore complex interacting protein family member B15	0.6244	34
TBC1D3F	TBC1 domain family member 3F	0.6219	34
OR4N4	Olfactory receptor family 4 subfamily N member 4	0.6144	34
NPIPB6	Nuclear pore complex interacting protein family member B6	0.6102	34
PRB4	Proline rich protein BstNI subfamily 4	0.6073	34
OR8B2	Olfactory receptor family 8 subfamily B member 2	0.5992	34
PLCZ1	Phospholipase C zeta 1	0.5935	34
ADAM29	ADAM metallopeptidase domain 29	0.5919	34
PDCL2	Phosducin like 2	0.5914	29
TMCO2	Transmembrane and coiled-coil domains 2	0.5852	29
ZNF679	Zinc finger protein 679	0.5798	34
ZNF513	Zinc finger protein 513	0.5737	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.1 nTPM
Adipose tissue	23.0 nTPM
Breast	19.2 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	9.8 nTPM
Lung	9.8 nTPM

Astrocytes	23.2 nTPM
Brain	23.2 nTPM

B-cells	8.7 nTPM
Bone marrow	14.7 nTPM
PBMC	11.5 nTPM
Lymph node	10.8 nTPM
Kidney	9.5 nTPM
Liver	8.8 nTPM
Stomach	8.6 nTPM
Breast	8.1 nTPM
Spleen	7.9 nTPM
Adipose tissue	4.0 nTPM
Colon	3.2 nTPM

Dendritic cells	3.4 nTPM
Breast	4.3 nTPM
PBMC	4.0 nTPM
Adipose tissue	1.8 nTPM

Endothelial cells	13.4 nTPM
Heart muscle	22.1 nTPM
Pancreas	19.3 nTPM
Testis	16.9 nTPM
Skeletal muscle	16.3 nTPM
Endometrium	15.7 nTPM
Ovary	13.8 nTPM
Liver	13.7 nTPM
Breast	13.6 nTPM
Esophagus	12.4 nTPM
Placenta	11.9 nTPM
Skin	8.9 nTPM
Prostate	8.5 nTPM
Eye	8.1 nTPM
Lung	6.2 nTPM

Fibroblasts	8.9 nTPM
Adipose tissue	11.0 nTPM
Heart muscle	10.0 nTPM
Placenta	9.6 nTPM
Prostate	9.5 nTPM
Breast	9.1 nTPM
Lung	8.9 nTPM
Ovary	8.7 nTPM
Esophagus	8.5 nTPM
Skeletal muscle	8.1 nTPM
Stomach	7.4 nTPM
Skin	7.3 nTPM

Intestinal goblet cells	15.3 nTPM
Colon	19.3 nTPM
Rectum	13.7 nTPM
Small intestine	12.8 nTPM

Macrophages	9.5 nTPM
Spleen	16.5 nTPM
Testis	14.0 nTPM
Pancreas	12.8 nTPM
Bone marrow	12.5 nTPM
Ovary	11.9 nTPM
Breast	11.6 nTPM
Adipose tissue	11.0 nTPM
Prostate	10.3 nTPM
Endometrium	9.9 nTPM
Skeletal muscle	8.8 nTPM
Lung	7.6 nTPM
Esophagus	6.3 nTPM
Kidney	6.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	8.0 nTPM
Rectum	13.2 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	5.7 nTPM
Bone marrow	11.5 nTPM
Spleen	7.2 nTPM
Stomach	7.1 nTPM
Adipose tissue	2.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.7 nTPM
Bronchus	15.5 nTPM
Lung	5.8 nTPM

Smooth muscle cells	10.0 nTPM
Breast	14.4 nTPM
Esophagus	14.0 nTPM
Endometrium	12.7 nTPM
Adipose tissue	11.2 nTPM
Skeletal muscle	10.8 nTPM
Heart muscle	10.0 nTPM
Pancreas	9.3 nTPM
Ovary	7.7 nTPM
Prostate	7.5 nTPM
Skin	7.3 nTPM
Bronchus	4.8 nTPM

T-cells	4.4 nTPM
Skin	8.3 nTPM
Stomach	8.2 nTPM
Endometrium	7.9 nTPM
Lung	7.6 nTPM
Breast	6.0 nTPM
Spleen	5.9 nTPM
Bone marrow	5.6 nTPM
Lymph node	5.3 nTPM
Colon	4.3 nTPM
Skeletal muscle	3.3 nTPM
Liver	2.8 nTPM
Kidney	2.7 nTPM
Adipose tissue	2.6 nTPM
PBMC	2.5 nTPM
Ovary	2.2 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	4.1 nTPM
Skin	4.1 nTPM

Basal prostatic cells	10.6 nTPM
Prostate	10.6 nTPM

Basal respiratory cells	6.5 nTPM
Bronchus	6.5 nTPM

Collecting duct cells	12.9 nTPM
Kidney	12.9 nTPM

Undifferentiated cells	15.1 nTPM
Colon	17.4 nTPM
Rectum	16.4 nTPM
Small intestine	11.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC