Single cell type - ACTR1B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACTR1B
Gene descriptionⁱ Full gene name according to HGNC.	Actin related protein 1B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACTR1B is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
YDJC	YdjC chitooligosaccharide deacetylase homolog	0.5613	1
GRAMD1A	GRAM domain containing 1A	0.5134	3
VPS4A	Vacuolar protein sorting 4 homolog A	0.5107	39
JAGN1	Jagunal homolog 1	0.5019	39
DDB2	Damage specific DNA binding protein 2	0.4985	3
OXA1L	OXA1L mitochondrial inner membrane protein	0.4894	32
B2M	Beta-2-microglobulin	0.4888	3
HPS6	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	0.4845	47
RNASEH1	Ribonuclease H1	0.4836	55
LYPD1	LY6/PLAUR domain containing 1	0.4750	1
MANBAL	Mannosidase beta like	0.4734	22
MAPKAPK5	MAPK activated protein kinase 5	0.4723	53
MRPS18B	Mitochondrial ribosomal protein S18B	0.4713	39
HDDC3	HD domain containing 3	0.4700	39
HLA-B	Major histocompatibility complex, class I, B	0.4697	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.8 nTPM
Adipose tissue	51.5 nTPM
Breast	36.0 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	18.2 nTPM
Lung	18.2 nTPM

Astrocytes	15.0 nTPM
Brain	15.0 nTPM

B-cells	30.4 nTPM
Kidney	42.9 nTPM
PBMC	38.6 nTPM
Bone marrow	33.5 nTPM
Stomach	29.0 nTPM
Liver	28.7 nTPM
Breast	28.1 nTPM
Spleen	27.3 nTPM
Colon	27.1 nTPM
Adipose tissue	25.5 nTPM
Lymph node	23.0 nTPM

Dendritic cells	26.1 nTPM
PBMC	31.8 nTPM
Breast	23.6 nTPM
Adipose tissue	22.9 nTPM

Endothelial cells	30.9 nTPM
Testis	51.0 nTPM
Ovary	45.1 nTPM
Skeletal muscle	39.4 nTPM
Placenta	38.0 nTPM
Breast	37.0 nTPM
Heart muscle	33.8 nTPM
Prostate	32.0 nTPM
Esophagus	31.4 nTPM
Liver	30.2 nTPM
Eye	29.1 nTPM
Skin	19.3 nTPM
Endometrium	19.1 nTPM
Lung	15.6 nTPM
Pancreas	11.6 nTPM

Fibroblasts	24.3 nTPM
Esophagus	37.7 nTPM
Heart muscle	35.1 nTPM
Placenta	25.9 nTPM
Ovary	24.3 nTPM
Stomach	23.7 nTPM
Adipose tissue	22.9 nTPM
Prostate	20.6 nTPM
Breast	20.2 nTPM
Skin	19.1 nTPM
Skeletal muscle	19.1 nTPM
Lung	19.0 nTPM

Intestinal goblet cells	31.7 nTPM
Small intestine	38.3 nTPM
Rectum	33.3 nTPM
Colon	23.5 nTPM

Macrophages	17.4 nTPM
Prostate	36.7 nTPM
Bone marrow	22.5 nTPM
Testis	20.9 nTPM
Kidney	20.4 nTPM
Esophagus	20.4 nTPM
Breast	18.0 nTPM
Adipose tissue	17.0 nTPM
Lung	16.1 nTPM
Pancreas	15.3 nTPM
Skeletal muscle	14.6 nTPM
Ovary	14.1 nTPM
PBMC	13.6 nTPM
Stomach	11.7 nTPM
Spleen	10.4 nTPM
Endometrium	9.2 nTPM

Paneth cells	32.8 nTPM
Rectum	41.1 nTPM
Small intestine	37.6 nTPM
Colon	19.7 nTPM

Plasma cells	21.9 nTPM
Bone marrow	26.4 nTPM
Esophagus	24.6 nTPM
Stomach	23.5 nTPM
Spleen	22.1 nTPM
Adipose tissue	13.0 nTPM

Respiratory ciliated cells	22.2 nTPM
Bronchus	34.2 nTPM
Lung	10.2 nTPM

Smooth muscle cells	28.5 nTPM
Pancreas	40.9 nTPM
Skin	39.0 nTPM
Adipose tissue	36.9 nTPM
Prostate	34.7 nTPM
Skeletal muscle	33.9 nTPM
Esophagus	31.0 nTPM
Breast	29.1 nTPM
Ovary	22.5 nTPM
Heart muscle	22.3 nTPM
Endometrium	15.6 nTPM
Bronchus	7.6 nTPM

T-cells	31.4 nTPM
Liver	46.0 nTPM
Colon	45.1 nTPM
PBMC	41.5 nTPM
Kidney	40.4 nTPM
Skin	38.7 nTPM
Bone marrow	38.7 nTPM
Lymph node	36.6 nTPM
Stomach	35.4 nTPM
Spleen	32.2 nTPM
Breast	27.2 nTPM
Skeletal muscle	26.8 nTPM
Esophagus	26.2 nTPM
Adipose tissue	25.7 nTPM
Ovary	24.5 nTPM
Lung	21.3 nTPM
Prostate	14.2 nTPM
Endometrium	12.9 nTPM

Basal respiratory cells	28.4 nTPM
Bronchus	28.4 nTPM

Basal squamous epithelial cells	16.5 nTPM
Esophagus	16.5 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Undifferentiated cells	36.4 nTPM
Small intestine	43.8 nTPM
Rectum	40.9 nTPM
Colon	24.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC