Single cell type - PAPOLG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PAPOLG
Gene descriptionⁱ Full gene name according to HGNC.	Poly(A) polymerase gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PAPOLG is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 0.97
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PDS5A	PDS5 cohesin associated factor A	0.5986	59
EPS15	Epidermal growth factor receptor pathway substrate 15	0.4960	59
DENND4C	DENN domain containing 4C	0.4938	59
TRPM7	Transient receptor potential cation channel subfamily M member 7	0.4764	21
VCPIP1	Valosin containing protein interacting protein 1	0.4685	10
CCL4L2	C-C motif chemokine ligand 4 like 2	0.4661	63
PARP8	Poly(ADP-ribose) polymerase family member 8	0.4541	24
MAF	MAF bZIP transcription factor	0.4535	24
FBXO11	F-box protein 11	0.4514	44
PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5	0.4445	63
PPP3R1	Protein phosphatase 3 regulatory subunit B, alpha	0.4377	59
DENND6A	DENN domain containing 6A	0.4344	52
CCL4	C-C motif chemokine ligand 4	0.4335	63
RAB39A	RAB39A, member RAS oncogene family	0.4300	8
KLHL24	Kelch like family member 24	0.4278	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.5 nTPM
Adipose tissue	11.5 nTPM
Breast	11.5 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	12.2 nTPM
Lung	12.2 nTPM

Astrocytes	13.1 nTPM
Brain	13.1 nTPM

B-cells	13.9 nTPM
Lymph node	24.5 nTPM
Adipose tissue	24.0 nTPM
Spleen	21.8 nTPM
Stomach	20.4 nTPM
Bone marrow	14.7 nTPM
Breast	12.1 nTPM
Liver	6.4 nTPM
PBMC	5.7 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM

Dendritic cells	21.0 nTPM
Adipose tissue	37.5 nTPM
Breast	17.5 nTPM
PBMC	8.0 nTPM

Endothelial cells	10.9 nTPM
Eye	22.7 nTPM
Esophagus	17.0 nTPM
Heart muscle	14.5 nTPM
Prostate	14.3 nTPM
Testis	13.3 nTPM
Endometrium	11.9 nTPM
Skin	10.1 nTPM
Skeletal muscle	9.8 nTPM
Breast	8.9 nTPM
Ovary	8.8 nTPM
Liver	7.3 nTPM
Placenta	7.3 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM

Fibroblasts	11.0 nTPM
Stomach	16.3 nTPM
Esophagus	14.8 nTPM
Prostate	12.4 nTPM
Adipose tissue	11.7 nTPM
Skin	11.3 nTPM
Breast	11.1 nTPM
Skeletal muscle	10.6 nTPM
Lung	8.9 nTPM
Heart muscle	8.8 nTPM
Ovary	8.4 nTPM
Placenta	6.2 nTPM

Intestinal goblet cells	5.7 nTPM
Rectum	8.6 nTPM
Colon	5.0 nTPM
Small intestine	3.5 nTPM

Macrophages	17.8 nTPM
Adipose tissue	57.3 nTPM
Esophagus	28.3 nTPM
Prostate	27.5 nTPM
Ovary	25.4 nTPM
Testis	17.4 nTPM
Spleen	16.5 nTPM
Bone marrow	15.0 nTPM
Breast	14.4 nTPM
Kidney	12.9 nTPM
Stomach	11.7 nTPM
Skeletal muscle	11.6 nTPM
Endometrium	10.9 nTPM
Lung	10.5 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	6.0 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM
Rectum	4.0 nTPM

Plasma cells	12.7 nTPM
Adipose tissue	36.7 nTPM
Spleen	10.1 nTPM
Stomach	8.5 nTPM
Bone marrow	8.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	7.1 nTPM
Lung	8.7 nTPM
Bronchus	5.5 nTPM

Smooth muscle cells	11.3 nTPM
Bronchus	18.0 nTPM
Esophagus	17.0 nTPM
Adipose tissue	14.5 nTPM
Endometrium	12.6 nTPM
Prostate	11.9 nTPM
Breast	10.7 nTPM
Ovary	10.3 nTPM
Skin	9.4 nTPM
Heart muscle	8.5 nTPM
Skeletal muscle	7.9 nTPM
Pancreas	4.1 nTPM

T-cells	20.8 nTPM
Adipose tissue	39.7 nTPM
Spleen	29.5 nTPM
Skin	28.5 nTPM
Colon	28.0 nTPM
Lymph node	23.0 nTPM
Stomach	22.5 nTPM
Bone marrow	21.7 nTPM
Breast	21.1 nTPM
Esophagus	19.7 nTPM
Endometrium	19.0 nTPM
Skeletal muscle	17.7 nTPM
Liver	17.4 nTPM
Lung	16.7 nTPM
Kidney	13.7 nTPM
Ovary	13.4 nTPM
PBMC	13.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	12.5 nTPM
Skin	12.5 nTPM

Basal prostatic cells	13.5 nTPM
Prostate	13.5 nTPM

Basal respiratory cells	4.6 nTPM
Bronchus	4.6 nTPM

Basal squamous epithelial cells	12.0 nTPM
Esophagus	12.0 nTPM

Undifferentiated cells	4.0 nTPM
Rectum	5.1 nTPM
Small intestine	4.0 nTPM
Colon	2.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC