Single cell type - ASH1L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ASH1L
Gene descriptionⁱ Full gene name according to HGNC.	ASH1 like histone lysine methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ASH1L is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FNBP4	Formin binding protein 4	0.5474	52
SRSF11	Serine and arginine rich splicing factor 11	0.5321	52
THOC2	THO complex 2	0.5299	10
CNOT4	CCR4-NOT transcription complex subunit 4	0.5274	10
CCNT2	Cyclin T2	0.5194	52
ATRX	ATRX chromatin remodeler	0.4984	52
NIPBL	NIPBL cohesin loading factor	0.4918	10
PNISR	PNN interacting serine and arginine rich protein	0.4827	52
ZNF207	Zinc finger protein 207	0.4813	52
RNF169	Ring finger protein 169	0.4753	52
PITPNB	Phosphatidylinositol transfer protein beta	0.4743	22
RBM39	RNA binding motif protein 39	0.4693	52
DDX5	DEAD-box helicase 5	0.4684	52
METTL16	Methyltransferase like 16	0.4593	52
N4BP2L2	NEDD4 binding protein 2 like 2	0.4558	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	96.5 nTPM
Adipose tissue	103.3 nTPM
Breast	89.7 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	103.2 nTPM
Lung	103.2 nTPM

Astrocytes	171.7 nTPM
Brain	171.7 nTPM

B-cells	108.3 nTPM
Adipose tissue	159.9 nTPM
Lymph node	135.9 nTPM
Colon	129.4 nTPM
Spleen	121.5 nTPM
PBMC	112.7 nTPM
Stomach	111.3 nTPM
Bone marrow	108.7 nTPM
Breast	99.0 nTPM
Kidney	66.6 nTPM
Liver	37.9 nTPM

Basal squamous epithelial cells	109.3 nTPM
Esophagus	109.3 nTPM

Dendritic cells	83.3 nTPM
Adipose tissue	121.7 nTPM
Breast	72.6 nTPM
PBMC	55.8 nTPM

Endothelial cells	77.6 nTPM
Prostate	109.9 nTPM
Skeletal muscle	108.7 nTPM
Heart muscle	102.5 nTPM
Endometrium	96.9 nTPM
Skin	91.9 nTPM
Testis	91.0 nTPM
Esophagus	84.2 nTPM
Breast	71.4 nTPM
Liver	66.0 nTPM
Lung	65.5 nTPM
Eye	64.7 nTPM
Ovary	64.0 nTPM
Pancreas	38.6 nTPM
Placenta	30.7 nTPM

Fibroblasts	93.7 nTPM
Prostate	150.3 nTPM
Heart muscle	117.8 nTPM
Lung	108.4 nTPM
Skin	107.5 nTPM
Adipose tissue	101.4 nTPM
Skeletal muscle	99.0 nTPM
Esophagus	88.0 nTPM
Breast	78.0 nTPM
Ovary	71.4 nTPM
Stomach	65.3 nTPM
Placenta	43.9 nTPM

Intestinal goblet cells	59.0 nTPM
Small intestine	64.4 nTPM
Colon	59.3 nTPM
Rectum	53.1 nTPM

Macrophages	69.1 nTPM
Adipose tissue	115.2 nTPM
Skeletal muscle	102.6 nTPM
Bone marrow	92.4 nTPM
Endometrium	85.1 nTPM
Prostate	84.8 nTPM
Esophagus	77.1 nTPM
Lung	69.8 nTPM
Spleen	67.4 nTPM
Breast	66.9 nTPM
Stomach	64.5 nTPM
Ovary	63.4 nTPM
Testis	61.0 nTPM
Kidney	57.5 nTPM
Pancreas	28.0 nTPM
PBMC	0.0 nTPM

Paneth cells	64.8 nTPM
Colon	69.2 nTPM
Rectum	65.1 nTPM
Small intestine	60.1 nTPM

Plasma cells	110.1 nTPM
Adipose tissue	207.7 nTPM
Esophagus	117.0 nTPM
Stomach	105.3 nTPM
Spleen	64.3 nTPM
Bone marrow	56.0 nTPM

Respiratory ciliated cells	47.1 nTPM
Lung	49.5 nTPM
Bronchus	44.7 nTPM

Smooth muscle cells	104.6 nTPM
Heart muscle	173.0 nTPM
Bronchus	132.4 nTPM
Adipose tissue	127.2 nTPM
Prostate	121.9 nTPM
Skeletal muscle	121.5 nTPM
Endometrium	112.7 nTPM
Skin	102.6 nTPM
Breast	90.1 nTPM
Esophagus	88.3 nTPM
Ovary	51.5 nTPM
Pancreas	29.3 nTPM

Cholangiocytes	50.1 nTPM
Liver	50.1 nTPM

Cone photoreceptor cells	202.3 nTPM
Eye	202.3 nTPM

Cytotrophoblasts	53.6 nTPM
Placenta	53.6 nTPM

Distal enterocytes	76.2 nTPM
Colon	80.7 nTPM
Rectum	71.8 nTPM

T-cells	98.7 nTPM
Skeletal muscle	165.4 nTPM
Adipose tissue	142.6 nTPM
PBMC	130.6 nTPM
Lymph node	121.7 nTPM
Endometrium	115.6 nTPM
Prostate	113.7 nTPM
Spleen	102.0 nTPM
Breast	99.3 nTPM
Stomach	96.4 nTPM
Bone marrow	90.4 nTPM
Colon	89.3 nTPM
Lung	80.5 nTPM
Skin	76.8 nTPM
Kidney	74.0 nTPM
Liver	62.6 nTPM
Esophagus	58.9 nTPM
Ovary	57.8 nTPM

Undifferentiated cells	60.2 nTPM
Colon	77.8 nTPM
Rectum	53.8 nTPM
Small intestine	49.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC