Single cell type - IVNS1ABP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IVNS1ABP
Gene descriptionⁱ Full gene name according to HGNC.	Influenza virus NS1A binding protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IVNS1ABP is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FOSL2	FOS like 2, AP-1 transcription factor subunit	0.6001	24
CES3	Carboxylesterase 3	0.5775	53
BMP3	Bone morphogenetic protein 3	0.5757	40
SIGLEC11	Sialic acid binding Ig like lectin 11	0.5649	40
SCUBE1	Signal peptide, CUB domain and EGF like domain containing 1	0.5606	40
LPIN2	Lipin 2	0.5570	40
DGLUCY	D-glutamate cyclase	0.5480	40
GREB1	Growth regulating estrogen receptor binding 1	0.5463	40
NR5A2	Nuclear receptor subfamily 5 group A member 2	0.5449	40
HS6ST1	Heparan sulfate 6-O-sulfotransferase 1	0.5446	40
IFNA13	Interferon alpha 13	0.5424	40
LRAT	Lecithin retinol acyltransferase	0.5390	40
LMBR1L	Limb development membrane protein 1 like	0.5388	40
KYAT1	Kynurenine aminotransferase 1	0.5361	40
KCTD15	Potassium channel tetramerization domain containing 15	0.5356	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	159.1 nTPM
Adipose tissue	226.9 nTPM
Breast	91.3 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	59.0 nTPM
Lung	59.0 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	61.3 nTPM
Stomach	115.8 nTPM
Adipose tissue	96.8 nTPM
Lymph node	83.7 nTPM
Breast	80.3 nTPM
Colon	78.3 nTPM
Spleen	60.2 nTPM
Kidney	28.5 nTPM
PBMC	27.1 nTPM
Bone marrow	26.2 nTPM
Liver	16.3 nTPM

Basal squamous epithelial cells	163.4 nTPM
Esophagus	163.4 nTPM

Dendritic cells	102.0 nTPM
Adipose tissue	160.0 nTPM
Breast	134.1 nTPM
PBMC	12.0 nTPM

Endothelial cells	85.8 nTPM
Prostate	283.9 nTPM
Ovary	128.0 nTPM
Skin	110.7 nTPM
Breast	98.2 nTPM
Lung	96.7 nTPM
Skeletal muscle	74.4 nTPM
Endometrium	69.8 nTPM
Pancreas	69.5 nTPM
Eye	58.2 nTPM
Placenta	56.3 nTPM
Esophagus	54.0 nTPM
Heart muscle	49.4 nTPM
Testis	35.9 nTPM
Liver	16.5 nTPM

Fibroblasts	50.3 nTPM
Lung	124.0 nTPM
Prostate	70.8 nTPM
Skin	62.6 nTPM
Stomach	60.9 nTPM
Ovary	42.4 nTPM
Breast	38.2 nTPM
Esophagus	36.6 nTPM
Heart muscle	34.1 nTPM
Skeletal muscle	31.8 nTPM
Placenta	29.4 nTPM
Adipose tissue	21.9 nTPM

Intestinal goblet cells	109.6 nTPM
Colon	126.5 nTPM
Rectum	105.8 nTPM
Small intestine	96.4 nTPM

Macrophages	141.5 nTPM
Stomach	284.2 nTPM
Adipose tissue	273.4 nTPM
Spleen	244.7 nTPM
Skeletal muscle	216.0 nTPM
Esophagus	203.0 nTPM
Lung	197.3 nTPM
Breast	134.8 nTPM
Prostate	118.1 nTPM
Ovary	98.4 nTPM
Endometrium	84.7 nTPM
Testis	63.3 nTPM
Kidney	59.0 nTPM
PBMC	54.6 nTPM
Bone marrow	50.0 nTPM
Pancreas	40.8 nTPM

Paneth cells	56.4 nTPM
Rectum	96.5 nTPM
Colon	42.8 nTPM
Small intestine	30.0 nTPM

Plasma cells	62.7 nTPM
Adipose tissue	145.7 nTPM
Esophagus	92.4 nTPM
Spleen	32.8 nTPM
Stomach	27.6 nTPM
Bone marrow	14.8 nTPM

Respiratory ciliated cells	45.8 nTPM
Lung	51.0 nTPM
Bronchus	40.6 nTPM

Smooth muscle cells	52.6 nTPM
Ovary	187.2 nTPM
Skin	59.0 nTPM
Esophagus	49.6 nTPM
Prostate	49.4 nTPM
Bronchus	46.1 nTPM
Endometrium	43.9 nTPM
Skeletal muscle	36.9 nTPM
Breast	34.8 nTPM
Adipose tissue	28.8 nTPM
Heart muscle	24.7 nTPM
Pancreas	18.1 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	128.8 nTPM
Kidney	128.8 nTPM

Cone photoreceptor cells	52.1 nTPM
Eye	52.1 nTPM

Cytotrophoblasts	17.3 nTPM
Placenta	17.3 nTPM

T-cells	120.0 nTPM
Adipose tissue	242.5 nTPM
Endometrium	239.8 nTPM
Stomach	190.1 nTPM
Breast	174.5 nTPM
Colon	150.6 nTPM
Skin	140.5 nTPM
Ovary	113.5 nTPM
Skeletal muscle	111.2 nTPM
Spleen	109.5 nTPM
Esophagus	104.8 nTPM
Lymph node	94.1 nTPM
Lung	89.6 nTPM
Prostate	80.4 nTPM
Bone marrow	76.2 nTPM
Liver	45.8 nTPM
Kidney	41.8 nTPM
PBMC	34.1 nTPM

Undifferentiated cells	102.7 nTPM
Colon	117.8 nTPM
Rectum	102.3 nTPM
Small intestine	88.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC