Single cell type - EBNA1BP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EBNA1BP2
Gene descriptionⁱ Full gene name according to HGNC.	EBNA1 binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EBNA1BP2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BYSL	Bystin like	0.6665	39
MRTO4	MRT4 homolog, ribosome maturation factor	0.5656	39
ALDH1B1	Aldehyde dehydrogenase 1 family member B1	0.5538	39
PDCD5	Programmed cell death 5	0.5421	10
EI24	EI24 autophagy associated transmembrane protein	0.5391	2
NOP16	NOP16 nucleolar protein	0.5286	39
ZNF593	Zinc finger protein 593	0.5269	39
DPH2	Diphthamide biosynthesis 2	0.5254	39
SRRD	SRR1 domain containing	0.5229	1
PNO1	Partner of NOB1 homolog	0.5205	39
CCT6A	Chaperonin containing TCP1 subunit 6A	0.5155	39
ATAD3A	ATPase family AAA domain containing 3A	0.5128	39
TIMM17A	Translocase of inner mitochondrial membrane 17A	0.5102	55
GLRX3	Glutaredoxin 3	0.5085	10
PIGW	Phosphatidylinositol glycan anchor biosynthesis class W	0.5081	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.0 nTPM
Breast	49.0 nTPM
Adipose tissue	26.9 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	39.5 nTPM
Lung	39.5 nTPM

Astrocytes	5.9 nTPM
Brain	5.9 nTPM

B-cells	36.9 nTPM
Liver	117.4 nTPM
Breast	40.2 nTPM
PBMC	35.7 nTPM
Kidney	33.4 nTPM
Spleen	30.8 nTPM
Stomach	27.3 nTPM
Bone marrow	25.3 nTPM
Colon	23.9 nTPM
Lymph node	19.8 nTPM
Adipose tissue	15.6 nTPM

Dendritic cells	23.3 nTPM
Breast	36.1 nTPM
Adipose tissue	17.8 nTPM
PBMC	16.0 nTPM

Endothelial cells	51.0 nTPM
Pancreas	169.9 nTPM
Placenta	70.5 nTPM
Prostate	65.4 nTPM
Ovary	54.3 nTPM
Lung	43.7 nTPM
Breast	42.3 nTPM
Skin	42.1 nTPM
Esophagus	40.2 nTPM
Testis	40.0 nTPM
Endometrium	37.7 nTPM
Skeletal muscle	35.3 nTPM
Heart muscle	26.4 nTPM
Eye	23.5 nTPM
Liver	22.9 nTPM

Fibroblasts	51.5 nTPM
Lung	118.4 nTPM
Prostate	78.5 nTPM
Placenta	68.5 nTPM
Ovary	53.5 nTPM
Heart muscle	44.2 nTPM
Adipose tissue	40.4 nTPM
Skin	39.3 nTPM
Skeletal muscle	37.4 nTPM
Breast	35.9 nTPM
Esophagus	25.3 nTPM
Stomach	25.3 nTPM

Intestinal goblet cells	49.7 nTPM
Colon	73.6 nTPM
Rectum	41.3 nTPM
Small intestine	34.0 nTPM

Macrophages	28.9 nTPM
Pancreas	68.9 nTPM
Kidney	57.5 nTPM
Lung	38.7 nTPM
Esophagus	36.2 nTPM
Breast	33.9 nTPM
Testis	32.0 nTPM
Endometrium	27.3 nTPM
Ovary	24.4 nTPM
Stomach	23.5 nTPM
Bone marrow	22.5 nTPM
Skeletal muscle	22.1 nTPM
Adipose tissue	18.8 nTPM
Prostate	16.0 nTPM
Spleen	11.4 nTPM
PBMC	0.0 nTPM

Paneth cells	25.8 nTPM
Rectum	53.1 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	53.1 nTPM
Spleen	91.7 nTPM
Bone marrow	80.7 nTPM
Stomach	42.5 nTPM
Esophagus	36.9 nTPM
Adipose tissue	13.6 nTPM

Respiratory ciliated cells	81.3 nTPM
Lung	94.8 nTPM
Bronchus	67.9 nTPM

Smooth muscle cells	68.1 nTPM
Pancreas	206.6 nTPM
Bronchus	126.2 nTPM
Prostate	65.3 nTPM
Ovary	63.8 nTPM
Skin	57.2 nTPM
Breast	51.0 nTPM
Skeletal muscle	49.0 nTPM
Esophagus	38.8 nTPM
Endometrium	35.4 nTPM
Adipose tissue	29.7 nTPM
Heart muscle	26.5 nTPM

T-cells	26.8 nTPM
Lung	45.6 nTPM
Ovary	40.0 nTPM
Kidney	36.3 nTPM
PBMC	32.7 nTPM
Stomach	31.2 nTPM
Colon	30.9 nTPM
Breast	28.7 nTPM
Endometrium	27.5 nTPM
Bone marrow	27.0 nTPM
Liver	25.0 nTPM
Skeletal muscle	23.6 nTPM
Spleen	23.4 nTPM
Skin	23.0 nTPM
Lymph node	22.3 nTPM
Adipose tissue	16.6 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	123.0 nTPM
Skin	123.0 nTPM

Basal prostatic cells	91.6 nTPM
Prostate	91.6 nTPM

Basal respiratory cells	78.0 nTPM
Bronchus	78.0 nTPM

Basal squamous epithelial cells	40.5 nTPM
Esophagus	40.5 nTPM

Undifferentiated cells	66.2 nTPM
Colon	83.4 nTPM
Rectum	57.8 nTPM
Small intestine	57.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC