Single cell type - SGK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SGK1
Gene descriptionⁱ Full gene name according to HGNC.	Serum/glucocorticoid regulated kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells, Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (eosinophil, neutrophil, classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC, RPTEC TERT1, SK-MEL-30, TIME, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells, Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SGK1 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CHMP1B	Charged multivesicular body protein 1B	0.6505	41
ADA2	Adenosine deaminase 2	0.6385	41
HLA-DRB5	Major histocompatibility complex, class II, DR beta 5	0.6370	41
HLA-DRB1	Major histocompatibility complex, class II, DR beta 1	0.6358	41
KDM6B	Lysine demethylase 6B	0.6182	41
PPP1R15B	Protein phosphatase 1 regulatory subunit 15B	0.6145	41
NFKBID	NFKB inhibitor delta	0.6123	41
GNA13	G protein subunit alpha 13	0.6095	41
MAP3K8	Mitogen-activated protein kinase kinase kinase 8	0.6066	41
CLEC10A	C-type lectin domain containing 10A	0.6016	41
VENTX	VENT homeobox	0.5984	41
HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1	0.5973	41
HLA-DRA	Major histocompatibility complex, class II, DR alpha	0.5963	41
DUSP1	Dual specificity phosphatase 1	0.5955	41
HLA-DQB1	Major histocompatibility complex, class II, DQ beta 1	0.5944	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	346.2 nTPM
Adipose tissue	404.3 nTPM
Breast	288.0 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	177.8 nTPM
Lung	177.8 nTPM

Astrocytes	34.0 nTPM
Brain	34.0 nTPM

B-cells	68.0 nTPM
Adipose tissue	229.1 nTPM
Breast	95.0 nTPM
Colon	94.2 nTPM
Lymph node	68.7 nTPM
Spleen	53.3 nTPM
Stomach	52.3 nTPM
Liver	38.0 nTPM
Kidney	28.5 nTPM
Bone marrow	16.4 nTPM
PBMC	4.3 nTPM

Basal squamous epithelial cells	329.0 nTPM
Esophagus	329.0 nTPM

Dendritic cells	27.0 nTPM
Breast	50.3 nTPM
Adipose tissue	30.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	232.1 nTPM
Esophagus	602.5 nTPM
Eye	487.1 nTPM
Liver	320.1 nTPM
Pancreas	297.3 nTPM
Skeletal muscle	272.8 nTPM
Skin	204.6 nTPM
Endometrium	200.4 nTPM
Breast	185.3 nTPM
Heart muscle	169.0 nTPM
Prostate	118.1 nTPM
Lung	115.4 nTPM
Ovary	107.6 nTPM
Testis	105.7 nTPM
Placenta	63.1 nTPM

Fibroblasts	88.8 nTPM
Lung	315.0 nTPM
Stomach	141.0 nTPM
Ovary	91.7 nTPM
Skin	88.8 nTPM
Esophagus	71.9 nTPM
Prostate	66.5 nTPM
Breast	54.9 nTPM
Adipose tissue	53.2 nTPM
Skeletal muscle	40.6 nTPM
Heart muscle	29.3 nTPM
Placenta	23.7 nTPM

Intestinal goblet cells	65.1 nTPM
Small intestine	116.9 nTPM
Colon	62.9 nTPM
Rectum	15.5 nTPM

Macrophages	492.5 nTPM
Adipose tissue	1714.8 nTPM
Esophagus	947.3 nTPM
Breast	835.3 nTPM
Endometrium	707.3 nTPM
Ovary	541.1 nTPM
Prostate	491.7 nTPM
Spleen	441.7 nTPM
Stomach	421.9 nTPM
Lung	387.2 nTPM
Skeletal muscle	333.9 nTPM
Testis	208.6 nTPM
Kidney	169.4 nTPM
Pancreas	135.2 nTPM
Bone marrow	52.4 nTPM
PBMC	0.0 nTPM

Paneth cells	123.9 nTPM
Small intestine	195.3 nTPM
Colon	148.2 nTPM
Rectum	28.1 nTPM

Plasma cells	92.4 nTPM
Adipose tissue	147.8 nTPM
Bone marrow	113.8 nTPM
Stomach	69.9 nTPM
Esophagus	67.8 nTPM
Spleen	63.0 nTPM

Respiratory ciliated cells	61.5 nTPM
Bronchus	96.9 nTPM
Lung	26.2 nTPM

Smooth muscle cells	102.9 nTPM
Bronchus	379.6 nTPM
Ovary	270.2 nTPM
Endometrium	99.2 nTPM
Esophagus	86.8 nTPM
Breast	65.5 nTPM
Prostate	60.3 nTPM
Skin	43.9 nTPM
Adipose tissue	43.9 nTPM
Skeletal muscle	36.1 nTPM
Pancreas	27.1 nTPM
Heart muscle	18.8 nTPM

Cholangiocytes	88.6 nTPM
Liver	88.6 nTPM

Cone photoreceptor cells	35.5 nTPM
Eye	35.5 nTPM

Cytotrophoblasts	41.0 nTPM
Placenta	41.0 nTPM

Distal enterocytes	132.2 nTPM
Colon	157.8 nTPM
Rectum	106.7 nTPM

T-cells	46.9 nTPM
Adipose tissue	96.6 nTPM
Breast	95.9 nTPM
Lung	88.1 nTPM
Prostate	80.4 nTPM
Lymph node	72.3 nTPM
Endometrium	69.0 nTPM
Esophagus	65.5 nTPM
Skin	59.9 nTPM
Skeletal muscle	56.7 nTPM
Ovary	26.7 nTPM
Spleen	24.1 nTPM
Stomach	18.8 nTPM
Kidney	14.4 nTPM
Colon	10.0 nTPM
Bone marrow	8.4 nTPM
Liver	6.4 nTPM
PBMC	3.8 nTPM

Undifferentiated cells	36.3 nTPM
Small intestine	74.0 nTPM
Colon	30.5 nTPM
Rectum	4.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC