Single cell type - RHOQ - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RHOQ
Gene descriptionⁱ Full gene name according to HGNC.	Ras homolog family member Q
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, eosinophil, intermediate monocyte, classical monocyte, naive B-cell, non-classical monocyte, memory B-cell, myeloid DC, basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RHOQ is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRKACA	Protein kinase cAMP-activated catalytic subunit alpha	0.5338	52
RAB31	RAB31, member RAS oncogene family	0.5322	41
ASAH1	N-acylsphingosine amidohydrolase 1	0.5104	4
VENTX	VENT homeobox	0.4932	41
C5AR2	Complement component 5a receptor 2	0.4922	41
PLN	Phospholamban	0.4911	54
KASH5	KASH domain containing 5	0.4855	54
SAP30	Sin3A associated protein 30	0.4824	41
TREML4	Triggering receptor expressed on myeloid cells like 4	0.4784	41
RELT	RELT TNF receptor	0.4734	41
NLRP3	NLR family pyrin domain containing 3	0.4696	41
VEGFA	Vascular endothelial growth factor A	0.4694	41
HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.4658	54
THBS1	Thrombospondin 1	0.4651	41
CASQ2	Calsequestrin 2	0.4647	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.9 nTPM
Breast	31.5 nTPM
Adipose tissue	24.3 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	22.4 nTPM
Lung	22.4 nTPM

Astrocytes	65.3 nTPM
Brain	65.3 nTPM

B-cells	38.1 nTPM
Adipose tissue	83.7 nTPM
Breast	64.1 nTPM
Colon	51.1 nTPM
Liver	43.1 nTPM
Spleen	28.3 nTPM
Stomach	28.2 nTPM
Lymph node	26.4 nTPM
PBMC	25.7 nTPM
Bone marrow	21.3 nTPM
Kidney	9.5 nTPM

Dendritic cells	32.2 nTPM
Adipose tissue	58.3 nTPM
Breast	22.2 nTPM
PBMC	16.0 nTPM

Endothelial cells	23.4 nTPM
Eye	49.3 nTPM
Prostate	45.9 nTPM
Heart muscle	29.6 nTPM
Lung	28.1 nTPM
Liver	27.5 nTPM
Endometrium	26.1 nTPM
Breast	24.3 nTPM
Ovary	23.8 nTPM
Skin	23.7 nTPM
Skeletal muscle	22.3 nTPM
Placenta	8.0 nTPM
Pancreas	7.7 nTPM
Esophagus	5.8 nTPM
Testis	5.4 nTPM

Fibroblasts	82.8 nTPM
Prostate	370.8 nTPM
Heart muscle	97.2 nTPM
Adipose tissue	89.2 nTPM
Skin	68.6 nTPM
Skeletal muscle	65.7 nTPM
Lung	55.9 nTPM
Breast	51.4 nTPM
Esophagus	42.3 nTPM
Stomach	23.7 nTPM
Placenta	23.5 nTPM
Ovary	22.3 nTPM

Intestinal goblet cells	5.5 nTPM
Colon	12.1 nTPM
Rectum	2.5 nTPM
Small intestine	1.8 nTPM

Macrophages	90.7 nTPM
Adipose tissue	268.1 nTPM
Ovary	119.4 nTPM
Skeletal muscle	117.0 nTPM
Spleen	114.1 nTPM
Esophagus	102.2 nTPM
Prostate	102.1 nTPM
Bone marrow	94.9 nTPM
Stomach	93.7 nTPM
Endometrium	80.3 nTPM
Lung	70.2 nTPM
Testis	67.9 nTPM
Breast	65.1 nTPM
Kidney	49.9 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	42.0 nTPM
Adipose tissue	56.8 nTPM
Stomach	45.1 nTPM
Bone marrow	39.5 nTPM
Spleen	38.1 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	18.8 nTPM
Bronchus	23.0 nTPM
Lung	14.6 nTPM

Smooth muscle cells	82.3 nTPM
Prostate	189.7 nTPM
Adipose tissue	122.7 nTPM
Skeletal muscle	110.2 nTPM
Endometrium	98.7 nTPM
Breast	95.9 nTPM
Skin	90.7 nTPM
Ovary	59.0 nTPM
Esophagus	51.2 nTPM
Heart muscle	46.1 nTPM
Pancreas	30.9 nTPM
Bronchus	10.3 nTPM

T-cells	17.0 nTPM
Endometrium	41.1 nTPM
Ovary	28.9 nTPM
Adipose tissue	27.9 nTPM
Colon	24.2 nTPM
Skeletal muscle	24.1 nTPM
Breast	24.0 nTPM
Liver	19.0 nTPM
Prostate	19.0 nTPM
Lung	15.2 nTPM
Skin	14.7 nTPM
Kidney	12.3 nTPM
Stomach	8.5 nTPM
Spleen	8.2 nTPM
Esophagus	6.6 nTPM
PBMC	5.9 nTPM
Bone marrow	5.0 nTPM
Lymph node	4.0 nTPM

Basal prostatic cells	31.0 nTPM
Prostate	31.0 nTPM

Basal respiratory cells	18.1 nTPM
Bronchus	18.1 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Undifferentiated cells	1.9 nTPM
Colon	3.4 nTPM
Rectum	1.5 nTPM
Small intestine	0.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC