Single cell type - TCP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TCP1
Gene descriptionⁱ Full gene name according to HGNC.	T-complex 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TCP1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPID	Peptidylprolyl isomerase D	0.6952	10
CCT5	Chaperonin containing TCP1 subunit 5	0.6711	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.6631	10
AHSA1	Activator of HSP90 ATPase activity 1	0.6472	22
PAPOLB	Poly(A) polymerase beta	0.6463	10
ZNF607	Zinc finger protein 607	0.6393	10
UTP18	UTP18 small subunit processome component	0.6374	10
CCT4	Chaperonin containing TCP1 subunit 4	0.6281	10
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.6280	10
COPS6	COP9 signalosome subunit 6	0.6273	10
PSMD12	Proteasome 26S subunit, non-ATPase 12	0.6273	10
PSMD6	Proteasome 26S subunit, non-ATPase 6	0.6262	10
NUP43	Nucleoporin 43	0.6234	10
WDR12	WD repeat domain 12	0.6167	10
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.6165	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	122.4 nTPM
Breast	131.6 nTPM
Adipose tissue	113.1 nTPM

Alveolar cells type 1	51.3 nTPM
Lung	51.3 nTPM

Alveolar cells type 2	38.8 nTPM
Lung	38.8 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	95.4 nTPM
Liver	157.1 nTPM
Colon	116.6 nTPM
Lymph node	106.0 nTPM
Breast	103.0 nTPM
Kidney	95.3 nTPM
Spleen	91.1 nTPM
Adipose tissue	79.7 nTPM
PBMC	78.5 nTPM
Stomach	71.3 nTPM
Bone marrow	55.6 nTPM

Dendritic cells	80.7 nTPM
Breast	105.7 nTPM
Adipose tissue	88.5 nTPM
PBMC	47.8 nTPM

Endothelial cells	106.4 nTPM
Prostate	326.8 nTPM
Pancreas	146.7 nTPM
Endometrium	139.3 nTPM
Skin	122.3 nTPM
Breast	108.8 nTPM
Testis	100.5 nTPM
Ovary	99.4 nTPM
Skeletal muscle	97.2 nTPM
Placenta	93.8 nTPM
Esophagus	75.3 nTPM
Liver	54.1 nTPM
Eye	49.3 nTPM
Heart muscle	48.6 nTPM
Lung	28.1 nTPM

Enteroendocrine cells	104.4 nTPM
Colon	145.7 nTPM
Rectum	63.1 nTPM

Erythroid cells	119.5 nTPM
Liver	149.9 nTPM
Bone marrow	89.1 nTPM

Fibroblasts	98.6 nTPM
Prostate	211.5 nTPM
Ovary	139.7 nTPM
Skin	134.7 nTPM
Placenta	95.1 nTPM
Stomach	95.0 nTPM
Breast	86.2 nTPM
Lung	78.2 nTPM
Skeletal muscle	76.2 nTPM
Adipose tissue	68.6 nTPM
Esophagus	60.9 nTPM
Heart muscle	38.4 nTPM

Intestinal goblet cells	84.6 nTPM
Colon	144.4 nTPM
Rectum	57.0 nTPM
Small intestine	52.5 nTPM

Macrophages	91.5 nTPM
Prostate	278.5 nTPM
Breast	131.9 nTPM
Endometrium	123.3 nTPM
Adipose tissue	113.3 nTPM
Pancreas	102.0 nTPM
Testis	81.3 nTPM
Esophagus	80.3 nTPM
Spleen	78.8 nTPM
Kidney	73.4 nTPM
Ovary	59.8 nTPM
Skeletal muscle	59.6 nTPM
PBMC	54.6 nTPM
Lung	50.0 nTPM
Bone marrow	45.0 nTPM
Stomach	41.0 nTPM

Paneth cells	75.7 nTPM
Colon	95.5 nTPM
Rectum	75.5 nTPM
Small intestine	56.3 nTPM

Plasma cells	93.0 nTPM
Spleen	155.3 nTPM
Bone marrow	130.1 nTPM
Adipose tissue	78.0 nTPM
Stomach	71.0 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	127.1 nTPM
Bronchus	156.5 nTPM
Lung	97.7 nTPM

Basal keratinocytes	171.7 nTPM
Skin	171.7 nTPM

Basal prostatic cells	304.4 nTPM
Prostate	304.4 nTPM

Basal respiratory cells	153.2 nTPM
Bronchus	153.2 nTPM

Cholangiocytes	81.5 nTPM
Liver	81.5 nTPM

Smooth muscle cells	247.2 nTPM
Bronchus	1365.3 nTPM
Pancreas	250.4 nTPM
Prostate	226.3 nTPM
Skin	158.4 nTPM
Ovary	149.6 nTPM
Endometrium	140.8 nTPM
Breast	114.5 nTPM
Skeletal muscle	105.9 nTPM
Esophagus	80.6 nTPM
Adipose tissue	72.0 nTPM
Heart muscle	55.4 nTPM

T-cells	116.6 nTPM
Prostate	492.3 nTPM
Colon	138.3 nTPM
Endometrium	129.9 nTPM
Skin	129.3 nTPM
Breast	122.2 nTPM
Lymph node	115.7 nTPM
Adipose tissue	100.8 nTPM
Spleen	92.5 nTPM
Kidney	89.0 nTPM
Skeletal muscle	83.8 nTPM
Liver	83.5 nTPM
PBMC	83.5 nTPM
Esophagus	78.6 nTPM
Stomach	73.5 nTPM
Ovary	66.8 nTPM
Bone marrow	58.0 nTPM
Lung	44.0 nTPM

Undifferentiated cells	133.8 nTPM
Colon	230.5 nTPM
Small intestine	95.7 nTPM
Rectum	75.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC