Single cell type - CCT5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCT5
Gene descriptionⁱ Full gene name according to HGNC.	Chaperonin containing TCP1 subunit 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCT5 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
WDR12	WD repeat domain 12	0.8357	10
ANGPTL6	Angiopoietin like 6	0.8194	10
GSTA5	Glutathione S-transferase alpha 5	0.8125	10
RRP9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein	0.7957	10
HMGA2	High mobility group AT-hook 2	0.7896	10
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.7829	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.7822	10
POLR1C	RNA polymerase I and III subunit C	0.7711	10
CCT4	Chaperonin containing TCP1 subunit 4	0.7704	10
GLRX3	Glutaredoxin 3	0.7678	10
PSMB2	Proteasome 20S subunit beta 2	0.7662	10
TSN	Translin	0.7637	10
POTEM	POTE ankyrin domain family member M	0.7580	10
ESD	Esterase D	0.7518	10
TXNDC9	Thioredoxin domain containing 9	0.7486	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	81.7 nTPM
Breast	97.7 nTPM
Adipose tissue	65.7 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	41.3 nTPM
Lung	41.3 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	71.5 nTPM
Liver	132.8 nTPM
Spleen	85.5 nTPM
Adipose tissue	69.7 nTPM
Breast	69.6 nTPM
Colon	63.9 nTPM
Lymph node	63.1 nTPM
Kidney	61.9 nTPM
Bone marrow	58.9 nTPM
PBMC	55.7 nTPM
Stomach	54.0 nTPM

Dendritic cells	60.7 nTPM
Breast	102.4 nTPM
Adipose tissue	71.8 nTPM
PBMC	8.0 nTPM

Endothelial cells	92.8 nTPM
Pancreas	243.2 nTPM
Prostate	136.2 nTPM
Ovary	135.1 nTPM
Placenta	124.5 nTPM
Lung	93.6 nTPM
Endometrium	91.8 nTPM
Testis	79.4 nTPM
Skeletal muscle	73.3 nTPM
Eye	65.5 nTPM
Breast	60.5 nTPM
Esophagus	58.2 nTPM
Liver	57.7 nTPM
Skin	52.3 nTPM
Heart muscle	27.3 nTPM

Enteroendocrine cells	70.9 nTPM
Colon	103.1 nTPM
Rectum	38.8 nTPM

Fibroblasts	81.8 nTPM
Ovary	165.2 nTPM
Lung	138.5 nTPM
Prostate	132.8 nTPM
Placenta	124.3 nTPM
Adipose tissue	69.4 nTPM
Skeletal muscle	62.4 nTPM
Stomach	55.0 nTPM
Breast	53.2 nTPM
Skin	46.1 nTPM
Esophagus	36.0 nTPM
Heart muscle	17.6 nTPM

Intestinal goblet cells	89.9 nTPM
Colon	122.9 nTPM
Small intestine	75.5 nTPM
Rectum	71.4 nTPM

Macrophages	84.0 nTPM
Pancreas	173.6 nTPM
Lung	109.1 nTPM
Kidney	108.9 nTPM
Endometrium	103.6 nTPM
Testis	91.2 nTPM
Prostate	86.0 nTPM
Breast	82.3 nTPM
Bone marrow	76.2 nTPM
Adipose tissue	75.4 nTPM
Skeletal muscle	72.2 nTPM
Ovary	70.4 nTPM
Stomach	64.5 nTPM
Spleen	61.1 nTPM
Esophagus	44.1 nTPM
PBMC	40.9 nTPM

Paneth cells	81.8 nTPM
Rectum	94.6 nTPM
Colon	75.8 nTPM
Small intestine	75.1 nTPM

Plasma cells	59.6 nTPM
Bone marrow	128.6 nTPM
Spleen	106.7 nTPM
Adipose tissue	29.1 nTPM
Stomach	21.2 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	131.7 nTPM
Bronchus	133.7 nTPM
Lung	129.7 nTPM

Smooth muscle cells	272.5 nTPM
Bronchus	1800.0 nTPM
Pancreas	349.8 nTPM
Ovary	212.7 nTPM
Prostate	131.6 nTPM
Endometrium	103.0 nTPM
Breast	93.6 nTPM
Skeletal muscle	88.3 nTPM
Skin	71.8 nTPM
Adipose tissue	66.3 nTPM
Esophagus	49.6 nTPM
Heart muscle	30.7 nTPM

Basal keratinocytes	88.2 nTPM
Skin	88.2 nTPM

Basal prostatic cells	172.1 nTPM
Prostate	172.1 nTPM

Basal respiratory cells	206.6 nTPM
Bronchus	206.6 nTPM

Basal squamous epithelial cells	60.3 nTPM
Esophagus	60.3 nTPM

T-cells	66.5 nTPM
Ovary	91.2 nTPM
Endometrium	83.1 nTPM
Breast	76.0 nTPM
Kidney	74.0 nTPM
PBMC	70.8 nTPM
Lung	69.8 nTPM
Colon	68.4 nTPM
Adipose tissue	67.4 nTPM
Esophagus	65.5 nTPM
Spleen	65.3 nTPM
Skeletal muscle	64.2 nTPM
Bone marrow	62.1 nTPM
Skin	60.8 nTPM
Lymph node	59.7 nTPM
Stomach	59.7 nTPM
Liver	55.4 nTPM
Prostate	37.9 nTPM

Undifferentiated cells	126.9 nTPM
Colon	187.8 nTPM
Small intestine	99.2 nTPM
Rectum	93.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC