Single cell type - MTERF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTERF2
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial transcription termination factor 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MTERF2 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.99
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF839	Zinc finger protein 839	0.4875	66
SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2	0.4571	35
ZBED9	Zinc finger BED-type containing 9	0.4237	66
NBPF3	NBPF member 3	0.4131	66
TPRG1	Tumor protein p63 regulated 1	0.4126	23
AK6	Adenylate kinase 6	0.4085	25
DNAJC21	DnaJ heat shock protein family (Hsp40) member C21	0.4071	66
FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1	0.4046	36
MTG2	Mitochondrial ribosome associated GTPase 2	0.4040	23
PKNOX1	PBX/knotted 1 homeobox 1	0.3995	22
STX17	Syntaxin 17	0.3987	23
ZNF429	Zinc finger protein 429	0.3963	52
TG	Thyroglobulin	0.3952	67
ZCWPW2	Zinc finger CW-type and PWWP domain containing 2	0.3891	66
KCNJ11	Potassium inwardly rectifying channel subfamily J member 11	0.3884	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Breast	12.9 nTPM
Adipose tissue	10.5 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	11.4 nTPM
Lung	11.4 nTPM

Astrocytes	24.8 nTPM
Brain	24.8 nTPM

B-cells	4.3 nTPM
Breast	12.1 nTPM
PBMC	7.1 nTPM
Liver	5.5 nTPM
Kidney	4.8 nTPM
Spleen	4.2 nTPM
Bone marrow	3.2 nTPM
Stomach	2.7 nTPM
Adipose tissue	2.0 nTPM
Lymph node	1.6 nTPM
Colon	0.0 nTPM

Dendritic cells	19.3 nTPM
PBMC	23.9 nTPM
Adipose tissue	17.8 nTPM
Breast	16.0 nTPM

Endothelial cells	9.1 nTPM
Skeletal muscle	20.6 nTPM
Prostate	14.1 nTPM
Liver	11.9 nTPM
Endometrium	11.8 nTPM
Breast	11.6 nTPM
Heart muscle	11.2 nTPM
Placenta	10.8 nTPM
Esophagus	10.3 nTPM
Testis	9.5 nTPM
Ovary	8.7 nTPM
Lung	6.2 nTPM
Eye	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM

Fibroblasts	12.7 nTPM
Heart muscle	24.2 nTPM
Skeletal muscle	16.8 nTPM
Breast	15.6 nTPM
Adipose tissue	14.6 nTPM
Placenta	13.9 nTPM
Ovary	12.9 nTPM
Prostate	12.7 nTPM
Stomach	11.9 nTPM
Esophagus	9.2 nTPM
Lung	7.8 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	4.4 nTPM
Small intestine	6.7 nTPM
Rectum	6.5 nTPM
Colon	0.0 nTPM

Macrophages	3.8 nTPM
Breast	12.0 nTPM
Skeletal muscle	5.7 nTPM
Kidney	5.3 nTPM
Esophagus	4.8 nTPM
Lung	4.7 nTPM
Endometrium	4.4 nTPM
Testis	4.0 nTPM
Prostate	3.4 nTPM
Ovary	3.3 nTPM
Adipose tissue	3.3 nTPM
Pancreas	2.5 nTPM
Spleen	2.1 nTPM
Bone marrow	1.2 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	7.6 nTPM
Rectum	11.7 nTPM
Small intestine	11.3 nTPM
Colon	0.0 nTPM

Plasma cells	4.8 nTPM
Adipose tissue	10.9 nTPM
Bone marrow	8.2 nTPM
Stomach	2.5 nTPM
Spleen	2.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	6.6 nTPM
Lung	13.1 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	10.3 nTPM
Prostate	24.7 nTPM
Skeletal muscle	17.6 nTPM
Breast	17.4 nTPM
Endometrium	14.8 nTPM
Adipose tissue	11.2 nTPM
Heart muscle	10.1 nTPM
Ovary	9.8 nTPM
Esophagus	4.6 nTPM
Pancreas	3.1 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	10.8 nTPM
Prostate	23.6 nTPM
Esophagus	19.7 nTPM
Breast	16.1 nTPM
Liver	14.7 nTPM
Kidney	13.7 nTPM
Ovary	13.4 nTPM
Lung	12.2 nTPM
Skeletal muscle	11.9 nTPM
PBMC	11.7 nTPM
Endometrium	10.3 nTPM
Adipose tissue	9.9 nTPM
Stomach	8.2 nTPM
Spleen	7.1 nTPM
Bone marrow	6.6 nTPM
Lymph node	4.9 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM

Basal prostatic cells	20.2 nTPM
Prostate	20.2 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Distal tubular cells	39.2 nTPM
Kidney	39.2 nTPM

Undifferentiated cells	8.1 nTPM
Small intestine	14.3 nTPM
Rectum	10.0 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC