Cell line - PEX16 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PEX16
Gene descriptionⁱ Full gene name according to HGNC.	Peroxisomal biogenesis factor 16
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HEK293 & PC-3 - Transcription regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

PEX16 is part of cluster 19 HEK293 & PC-3 - Transcription regulation with confidenceⁱ 0.97
723 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATG2A	Autophagy related 2A	0.6045	19
FBXL8	F-box and leucine rich repeat protein 8	0.6028	6
NUDT22	Nudix hydrolase 22	0.5874	19
UBALD1	UBA like domain containing 1	0.5767	19
BAD	BCL2 associated agonist of cell death	0.5751	19
C5AR2	Complement component 5a receptor 2	0.5731	6
DENND2C	DENN domain containing 2C	0.5634	29
OGFOD2	2-oxoglutarate and iron dependent oxygenase domain containing 2	0.5623	6
NAXE	NAD(P)HX epimerase	0.5617	40
RPS6KB2	Ribosomal protein S6 kinase B2	0.5615	26
SLC4A5	Solute carrier family 4 member 5	0.5585	29
ESR1	Estrogen receptor 1	0.5577	6
AP5Z1	Adaptor related protein complex 5 subunit zeta 1	0.5573	24
SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	0.5549	40
VCX3A	Variable charge X-linked 3A	0.5492	29