Single cell type - STX16 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STX16
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin 16
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STX16 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAS2R14	Taste 2 receptor member 14	0.6965	52
EME2	Essential meiotic structure-specific endonuclease subunit 2	0.6299	52
MAN2C1	Mannosidase alpha class 2C member 1	0.5913	52
TAS2R4	Taste 2 receptor member 4	0.5848	11
DDX17	DEAD-box helicase 17	0.5738	52
NPHP3	Nephrocystin 3	0.5684	52
NPEPL1	Aminopeptidase like 1	0.5605	52
ZNF445	Zinc finger protein 445	0.5587	52
AGO1	Argonaute RISC component 1	0.5473	52
MLLT6	MLLT6, PHD finger containing	0.5371	56
TTLL3	Tubulin tyrosine ligase like 3	0.5294	52
UVSSA	UV stimulated scaffold protein A	0.5282	52
SLF2	SMC5-SMC6 complex localization factor 2	0.5259	52
FAM111A	Family with sequence similarity 111 member A	0.5214	52
WDR73	WD repeat domain 73	0.5206	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.2 nTPM
Adipose tissue	44.3 nTPM
Breast	36.0 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	46.6 nTPM
Lung	46.6 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	27.0 nTPM
Adipose tissue	47.1 nTPM
Colon	33.5 nTPM
PBMC	31.5 nTPM
Liver	27.8 nTPM
Stomach	24.5 nTPM
Bone marrow	22.9 nTPM
Lymph node	22.6 nTPM
Spleen	22.2 nTPM
Kidney	19.0 nTPM
Breast	18.7 nTPM

Dendritic cells	33.7 nTPM
Adipose tissue	48.8 nTPM
Breast	28.4 nTPM
PBMC	23.9 nTPM

Endothelial cells	36.3 nTPM
Heart muscle	62.4 nTPM
Lung	56.1 nTPM
Endometrium	40.6 nTPM
Skeletal muscle	39.7 nTPM
Eye	38.8 nTPM
Liver	36.7 nTPM
Testis	35.3 nTPM
Breast	34.3 nTPM
Placenta	34.1 nTPM
Esophagus	33.0 nTPM
Ovary	32.9 nTPM
Skin	32.2 nTPM
Prostate	24.6 nTPM
Pancreas	7.7 nTPM

Fibroblasts	28.3 nTPM
Adipose tissue	42.7 nTPM
Skeletal muscle	42.2 nTPM
Lung	36.9 nTPM
Breast	31.6 nTPM
Ovary	31.4 nTPM
Esophagus	27.9 nTPM
Skin	21.8 nTPM
Stomach	20.8 nTPM
Prostate	20.1 nTPM
Heart muscle	18.5 nTPM
Placenta	17.8 nTPM

Intestinal goblet cells	25.4 nTPM
Rectum	32.9 nTPM
Small intestine	30.6 nTPM
Colon	12.9 nTPM

Macrophages	37.1 nTPM
Adipose tissue	51.8 nTPM
Ovary	51.7 nTPM
Lung	51.4 nTPM
Bone marrow	48.7 nTPM
Skeletal muscle	46.8 nTPM
Spleen	44.6 nTPM
Breast	39.7 nTPM
Stomach	38.1 nTPM
Endometrium	36.6 nTPM
Testis	36.0 nTPM
Prostate	32.0 nTPM
Kidney	26.5 nTPM
Esophagus	23.6 nTPM
Pancreas	15.3 nTPM
PBMC	13.6 nTPM

Paneth cells	22.5 nTPM
Small intestine	37.6 nTPM
Rectum	30.0 nTPM
Colon	0.0 nTPM

Plasma cells	16.2 nTPM
Adipose tissue	34.2 nTPM
Spleen	19.5 nTPM
Stomach	17.6 nTPM
Bone marrow	9.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	45.6 nTPM
Lung	49.5 nTPM
Bronchus	41.8 nTPM

Smooth muscle cells	30.4 nTPM
Adipose tissue	45.7 nTPM
Breast	36.4 nTPM
Endometrium	36.2 nTPM
Esophagus	34.1 nTPM
Skin	33.9 nTPM
Skeletal muscle	29.1 nTPM
Bronchus	28.1 nTPM
Heart muscle	27.0 nTPM
Ovary	24.8 nTPM
Prostate	23.5 nTPM
Pancreas	15.1 nTPM

T-cells	42.6 nTPM
Lung	65.3 nTPM
Esophagus	58.9 nTPM
Adipose tissue	55.6 nTPM
Breast	49.8 nTPM
Endometrium	49.2 nTPM
Skin	48.8 nTPM
Skeletal muscle	46.8 nTPM
PBMC	45.8 nTPM
Liver	41.6 nTPM
Colon	40.4 nTPM
Ovary	37.8 nTPM
Lymph node	37.3 nTPM
Spleen	34.3 nTPM
Bone marrow	33.7 nTPM
Kidney	31.5 nTPM
Stomach	29.1 nTPM
Prostate	19.0 nTPM

Basal keratinocytes	26.9 nTPM
Skin	26.9 nTPM

Basal prostatic cells	19.3 nTPM
Prostate	19.3 nTPM

Basal respiratory cells	22.8 nTPM
Bronchus	22.8 nTPM

Basal squamous epithelial cells	29.0 nTPM
Esophagus	29.0 nTPM

Undifferentiated cells	26.0 nTPM
Rectum	34.1 nTPM
Small intestine	30.8 nTPM
Colon	13.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC