Single cell type - MLLT6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MLLT6
Gene descriptionⁱ Full gene name according to HGNC.	MLLT6, PHD finger containing
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Bipolar cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Bipolar cells, NK-cells, Cone photoreceptor cells, Rod photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Bipolar cells, NK-cells, Cone photoreceptor cells, Rod photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MLLT6 is part of cluster 56 Bipolar cells - Visual perception with confidenceⁱ 1
199 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LINC00672	Long intergenic non-protein coding RNA 672	0.6024	63
KIRREL2	Kirre like nephrin family adhesion molecule 2	0.5706	56
SLC1A7	Solute carrier family 1 member 7	0.5617	56
GDF11	Growth differentiation factor 11	0.5608	56
TNRC6C	Trinucleotide repeat containing adaptor 6C	0.5530	9
RD3	Retinal degeneration 3, GUCY2D regulator	0.5490	9
PCDHB9	Protocadherin beta 9	0.5444	56
STX16	Syntaxin 16	0.5371	52
DGKE	Diacylglycerol kinase epsilon	0.5341	56
CCDC177	Coiled-coil domain containing 177	0.5337	56
KCNG4	Potassium voltage-gated channel modifier subfamily G member 4	0.5300	56
CABP2	Calcium binding protein 2	0.5288	56
GNB3	G protein subunit beta 3	0.5255	9
NEUROD4	Neuronal differentiation 4	0.5216	56
VSX1	Visual system homeobox 1	0.5184	56

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	60.8 nTPM
Adipose tissue	65.1 nTPM
Breast	56.5 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	46.8 nTPM
Lung	46.8 nTPM

Astrocytes	46.4 nTPM
Brain	46.4 nTPM

B-cells	35.3 nTPM
PBMC	80.0 nTPM
Colon	44.8 nTPM
Lymph node	42.2 nTPM
Spleen	37.7 nTPM
Adipose tissue	36.6 nTPM
Breast	26.8 nTPM
Kidney	23.8 nTPM
Bone marrow	22.1 nTPM
Liver	21.2 nTPM
Stomach	18.2 nTPM

Dendritic cells	69.5 nTPM
Adipose tissue	102.4 nTPM
Breast	90.1 nTPM
PBMC	16.0 nTPM

Endothelial cells	46.0 nTPM
Heart muscle	88.8 nTPM
Skeletal muscle	82.1 nTPM
Testis	54.8 nTPM
Breast	50.7 nTPM
Ovary	50.3 nTPM
Esophagus	50.2 nTPM
Endometrium	46.0 nTPM
Prostate	44.8 nTPM
Eye	43.7 nTPM
Liver	40.3 nTPM
Skin	38.4 nTPM
Placenta	29.6 nTPM
Pancreas	15.5 nTPM
Lung	9.3 nTPM

Fibroblasts	27.9 nTPM
Skeletal muscle	43.1 nTPM
Heart muscle	38.0 nTPM
Skin	31.6 nTPM
Prostate	31.1 nTPM
Esophagus	30.5 nTPM
Adipose tissue	29.2 nTPM
Breast	28.9 nTPM
Ovary	27.7 nTPM
Stomach	19.3 nTPM
Lung	17.9 nTPM
Placenta	9.3 nTPM

Intestinal goblet cells	31.5 nTPM
Rectum	39.3 nTPM
Small intestine	34.5 nTPM
Colon	20.8 nTPM

Macrophages	22.7 nTPM
Breast	41.4 nTPM
Esophagus	34.6 nTPM
Skeletal muscle	34.5 nTPM
Adipose tissue	33.1 nTPM
Endometrium	30.0 nTPM
Spleen	26.0 nTPM
Testis	20.9 nTPM
Ovary	20.5 nTPM
Lung	20.0 nTPM
Prostate	18.4 nTPM
Stomach	17.6 nTPM
Bone marrow	16.3 nTPM
Pancreas	15.3 nTPM
Kidney	11.4 nTPM
PBMC	0.0 nTPM

Paneth cells	25.6 nTPM
Rectum	34.4 nTPM
Small intestine	22.5 nTPM
Colon	19.7 nTPM

Plasma cells	28.0 nTPM
Adipose tissue	91.0 nTPM
Bone marrow	14.8 nTPM
Esophagus	12.3 nTPM
Stomach	11.3 nTPM
Spleen	10.7 nTPM

Respiratory ciliated cells	25.8 nTPM
Bronchus	35.5 nTPM
Lung	16.0 nTPM

Smooth muscle cells	37.0 nTPM
Skeletal muscle	67.9 nTPM
Adipose tissue	49.3 nTPM
Esophagus	46.5 nTPM
Skin	43.2 nTPM
Breast	42.6 nTPM
Ovary	41.9 nTPM
Endometrium	38.3 nTPM
Prostate	28.4 nTPM
Heart muscle	25.4 nTPM
Bronchus	18.8 nTPM
Pancreas	4.7 nTPM

T-cells	65.0 nTPM
PBMC	164.6 nTPM
Skeletal muscle	104.5 nTPM
Breast	85.5 nTPM
Adipose tissue	79.1 nTPM
Liver	74.2 nTPM
Endometrium	71.8 nTPM
Lymph node	67.0 nTPM
Skin	60.3 nTPM
Spleen	54.4 nTPM
Bone marrow	52.3 nTPM
Lung	51.6 nTPM
Ovary	51.2 nTPM
Kidney	46.5 nTPM
Colon	44.7 nTPM
Stomach	41.6 nTPM
Esophagus	32.8 nTPM
Prostate	23.6 nTPM

Basal prostatic cells	25.2 nTPM
Prostate	25.2 nTPM

Basal respiratory cells	20.2 nTPM
Bronchus	20.2 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Cytotrophoblasts	20.1 nTPM
Placenta	20.1 nTPM

Undifferentiated cells	39.3 nTPM
Rectum	48.6 nTPM
Small intestine	47.1 nTPM
Colon	22.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC